Results 91 to 100 of about 3,996 (179)
Nature CommunicationsAs daughter centrioles assemble during G2, they recruit conserved Ana3/RTTN followed by its partner Rcd4/PPP1R35. Together, this contributes to the subsequent recruitment of Ana1/CEP295, required for the centriole’s conversion to a centrosome.
Pallavi Panda +2 more
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Revisiting Centrioles in Nematodes—Historic Findings and Current Topics
Cells, 2018 Theodor Boveri is considered as the “father” of centrosome biology. Boveri’s fundamental findings have laid the groundwork for decades of research on centrosomes.
Anna Schwarz +3 more
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Clinical and Translational Medicine, Volume 16, Issue 1, January 2026.Application of synthetic lethality screening in drug resistance models. Abstract Background and Rationale Synthetic lethality (SL)‐based strategies hold significant promise for overcoming therapeutic resistance, a critical bottleneck in cancer treatment where cancer cells evade anticancer therapies, leading to diminished efficacy or treatment failure ...
Junyan Li +4 more
wiley +1 more source
Direct binding of CEP85 to STIL ensures robust PLK4 activation and efficient centriole assembly
Nature Communications, 2018 Centriole duplication is tightly regulated in vivo, but the underlying molecular mechanisms are incompletely understood. Here the authors use high-resolution structural and imaging methods to show that CEP85 directly interacts with STIL and mediates ...
Yi Liu +15 more
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Feedback loops in the Plk4–STIL–HsSAS6 network coordinate site selection for procentriole formation
Biology Open, 2019 Centrioles are duplicated once in every cell cycle, ensuring the bipolarity of the mitotic spindle. How the core components cooperate to achieve high fidelity in centriole duplication remains poorly understood. By live-cell imaging of endogenously tagged
Daisuke Takao +3 more
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Reproductive Medicine and Biology, Volume 25, Issue 1, January/December 2026.ABSTRACT Background Multinucleation occurs at high frequency during the first mitosis of human embryos and is associated with impaired developmental potential. Our live‐imaging analyses showed that collapse of spindle geometry—such as low‐aspect ratio spindles and pole defocusing—correlates with multinucleation, yet molecular links from aberrant ...
Yuki Ono, Yukihiro Terada
wiley +1 more source
The FEBS Journal, Volume 293, Issue 2, Page 396-417, January 2026.KDM4A, a chromatin eraser, localizes to the centrosomes. Its demethylase activity is essential for maintaining centrosome number and integrity, independent of gene expression changes. Loss of KDM4A leads to centrosome amplification, pseudo‐bipolar spindle formation, and chromosome segregation errors, including micronuclei and chromatin bridges.
Pratim Chowdhury +16 more
wiley +1 more source
Taking Down the Primary Cilium: Pathways for Disassembly in Differentiating Cells
BioEssays, Volume 47, Issue 11, November 2025.Primary cilia are developmentally essential subcellular signaling compartments. However, many differentiated cells lack primary cilia, and cilia disassembly in these tissue contexts has been largely overlooked. We highlight several pathways for primary cilia loss and examine how changes in ciliation states could contribute to diverse pathologies ...
Carolyn M. Ott, Saikat Mukhopadhyay
wiley +1 more source
REGULATION OF CENTRIOLE DUPLICATION DURING MAMMALIAN SPERMATOGENESIS
, 2021 Bipolar spindle formation in meiotic cell division is essential to ensure faithful chromosome segregation and preclude gamete aneuploidy, of which a number of human diseases are associated.
Simington, Carter Joseph
core
The interrelationship between APC/C and Plk1 activities in centriole disengagement
Biology Open, 2012 Summary Mother–daughter centriole disengagement, the necessary first step in centriole duplication, involves Plk1 activity in early mitosis and separase activity after APC/C activity mediates securin degradation.
Toshiyuki Hatano, Greenfield Sluder
doaj +1 more source