Results 91 to 100 of about 83,983 (175)

LZTS2 Negatively Regulates Centrosomal CEP135 Levels and Microtubule Nucleation

Cytoskeleton, Volume 83, Issue 3, Page 128-139, March 2026.
ABSTRACT The microtubule cytoskeleton is a fundamental functional component of the cell. In vertebrate proliferating cells, centrosomes are the primary microtubule organizing center (MTOC), and their dysregulation has been linked to genomic instability and cancer.
Catarina Peneda, Joana N. Bugalhao, Marco Antonio Dias Louro, Andreia Henriques‐Soares, Monica Bettencourt‐Dias   +4 more
wiley   +1 more source

Vesicular trafficking plays a role in centriole disengagement and duplication

Molecular Biology of the Cell, 2018
Centrosomes are the major microtubule-nucleating and microtubule-organizing centers of cells and play crucial roles in microtubule anchoring, organelle positioning, and ciliogenesis. At the centrosome core lies a tightly associated or “engaged” mother–daughter centriole pair.
Xie, Shuwei, Reinecke, James B., Farmer, Trey, Bahl, Kriti, Yeow, Ivana, Nichols, Benjamin J., McLamarrah, Tiffany A., Naslavsky, Naava, Rogers, Gregory C., Caplan, Steve   +9 more
openaire   +2 more sources

Astrin is required for the maintenance of sister chromatid cohesion and centrosome integrity [PDF]

, 2007
Faithful chromosome segregation in mitosis requires the formation of a bipolar mitotic spindle with stably attached chromosomes. Once all of the chromosomes are aligned, the connection between the sister chromatids is severed by the cysteine protease ...
Erich A. Nigg, Kleylein-Sohn, J, Nigg, EA, Thein, Kerstin H., Kerstin H. Thein, Gruneberg, Ulrike, Nigg, E. A., Grueneberg, U., Julia Kleylein-Sohn, Thein, KH, Kleylein-Sohn, Julia, Kleylein-Sohn, J., Ulrike Gruneberg, Nigg, Erich A., Thein, K. H.   +14 more
core   +1 more source

Direct binding of CEP85 to STIL ensures robust PLK4 activation and efficient centriole assembly

Nature Communications, 2018
Centriole duplication is tightly regulated in vivo, but the underlying molecular mechanisms are incompletely understood. Here the authors use high-resolution structural and imaging methods to show that CEP85 directly interacts with STIL and mediates ...
Yi Liu, Gagan D. Gupta, Deepak D. Barnabas, Fikret G. Agircan, Shahid Mehmood, Di Wu, Etienne Coyaud, Christopher M. Johnson, Stephen H. McLaughlin, Antonina Andreeva, Stefan M. V. Freund, Carol V. Robinson, Sally W. T. Cheung, Brian Raught, Laurence Pelletier, Mark van Breugel   +15 more
doaj   +1 more source

Feedback loops in the Plk4–STIL–HsSAS6 network coordinate site selection for procentriole formation

Biology Open, 2019
Centrioles are duplicated once in every cell cycle, ensuring the bipolarity of the mitotic spindle. How the core components cooperate to achieve high fidelity in centriole duplication remains poorly understood. By live-cell imaging of endogenously tagged
Daisuke Takao, Koki Watanabe, Kanako Kuroki, Daiju Kitagawa   +3 more
doaj   +1 more source

Parkinson's‐Linked LRRK2 and GBA1 Mutations Modulate the Peripheral Immune Response to Pseudomonas aeruginosa

Movement Disorders, Volume 41, Issue 3, Page 651-666, March 2026.
Abstract Background Peripheral disease mechanisms such as immune dysregulation may contribute to Parkinson's disease (PD). To investigate interactions between common PD mutations and immune responses to environmental pathogens, we studied responses to Pseudomonas aeruginosa (P.
Julian R. Mark, Hannah A. Staley, Ann M. Titus, Julian Agin‐Liebes, Alicia Garrido, Laura Hughes, Nicolas Dzamko, Rebecca L. Wallings, Malú Gámez Tansey   +8 more
wiley   +1 more source

Dissociating the Centrosomal Matrix Protein AKAP450 from Centrioles Impairs Centriole Duplication and Cell Cycle Progression [PDF]

Molecular Biology of the Cell, 2003
Centrosomes provide docking sites for regulatory molecules involved in the control of the cell division cycle. The centrosomal matrix contains several proteins, which anchor kinases and phosphatases. The large A-Kinase Anchoring Protein AKAP450 is acting as a scaffolding protein for other components of the cell signaling machinery.
Keryer, G., Witczak, O., Delouvée, A., Kemmner, W., Rouillard, D., Taskén, K., Bornens, M.   +6 more
openaire   +3 more sources

Polo‐like kinases and UV‐induced skin carcinogenesis: What we know and what's next

Photochemistry and Photobiology, Volume 102, Issue 2, Page 276-289, March/April 2026.
The polo‐like kinase (PLK) family plays distinct and critical roles in the regulation of cell cycle progression, and its dysregulation has been implicated in various cancers. Ultraviolet (UV) radiation is a well‐established environmental factor in the development of skin cancer.
Tanya Jaiswal, Durdana Muntaqua, Gagan Chhabra, Nihal Ahmad   +3 more
wiley   +1 more source

Synthetic lethality in cancer therapy: Mechanisms, models and clinical translation for overcoming therapeutic resistance

Clinical and Translational Medicine, Volume 16, Issue 1, January 2026.
Application of synthetic lethality screening in drug resistance models. Abstract Background and Rationale Synthetic lethality (SL)‐based strategies hold significant promise for overcoming therapeutic resistance, a critical bottleneck in cancer treatment where cancer cells evade anticancer therapies, leading to diminished efficacy or treatment failure ...
Junyan Li, Liyuan Zhang, Yan Shang, Juan Liu, Hailong Zhao   +4 more
wiley   +1 more source

Self-organization of Plk4 regulates symmetry breaking in centriole duplication

, 2018
During centriole duplication, a single daughter centriole is formed near the mother centriole. The mechanism that determines a single duplication site is unknown.
Daiju Kitagawa, Shohei Yamamoto
core   +1 more source