Results 1 to 10 of about 905 (118)
A cis‐eQTL genetic variant in PLK4 confers high risk of hepatocellular carcinoma
Cancer Medicine, 2019 Purpose The overexpression and knockdown of PLK4 were both reported to generate aneuploidy. Thus, we aimed to investigate whether genetic variants in PLK4 contribute to the development of hepatocellular carcinoma (HCC).
Cheng Wang, Xuehao Wang, Na Qin
exaly +2 more sources
Autoamplification and Competition Drive Symmetry Breaking: Initiation of Centriole Duplication by the PLK4-STIL Network [PDF]
iScience, 2018 Summary: Centrioles, the cores of centrosomes and cilia, duplicate every cell cycle to ensure their faithful inheritance. How only a single procentriole is produced on each mother centriole remains enigmatic.
Marcin Leda +2 more
doaj +2 more sources
Two-step phosphorylation of Ana2 by Plk4 is required for the sequential loading of Ana2 and Sas6 to initiate procentriole formation [PDF]
Open Biology, 2017 The conserved process of centriole duplication requires Plk4 kinase to recruit and promote interactions between Sas6 and Sas5/Ana2/STIL (respective nomenclature of worms/flies/humans).
Nikola Dzhindzhev +2 more
exaly +2 more sources
Scientific ReportsCentrosome amplification is a hallmark of cancer and PLK4 is one of the responsible factors for cancer associated centrosome amplification. Increased PLK4 levels was also shown to contribute to generation of cells with centriole amplification in ...
Batuhan Mert Kalkan
exaly +2 more sources
Polo-like kinase 4 as a potential predictive biomarker of chemoradioresistance in locally advanced rectal cancer [PDF]
Journal of Pathology and Translational Medicine, 2022 Background Polo-like kinase 4 (PLK4) is a serine/threonine protein kinase located in the centriole of the chromosome during the cell cycle. PLK4 overexpression has been described in a variety of many common human epithelial tumors.
Hyunseung Oh +8 more
doaj +1 more source
Polo-Like Kinase 4’s Critical Role in Cancer Development and Strategies for Plk4-Targeted Therapy
Frontiers in Oncology, 2021 Polo-like kinases (Plks) are critical regulatory molecules during the cell cycle process. This family has five members: Plk1, 2, 3, 4, and 5. Plk4 has been identified as a master regulator of centriole replication, and its aberrant expression is closely ...
Xiaoyang Zhang +3 more
doaj +1 more source
Frontiers in Oncology, 2022 Tumor immune microenvironment plays an important role in tumorigenesis and metastasis. Polo-like kinases 4 (PLK4) is a crucial regulatory factor in the process of cell cycle, and its abnormal regulation often leads to a variety of diseases including ...
Xiaoyang Zhang +8 more
doaj +1 more source
Cell Death and Disease, 2021 Polo-like kinase 4 (PLK4), a key regulator of centriole biogenesis, has recently been shown to play key roles in tumorigenesis. Blocking PLK4 expression by interference or targeted drugs exhibits attractive potential in improving the efficacy of ...
Yi Zhao +8 more
doaj +1 more source
FEBS Open Bio, 2021 Polo‐like kinase 4 (PLK4) has been reported to contribute to tumor growth, invasion, and metastasis. However, the role of PLK4 in human bladder cancer (BC) remains unclear.
Ziyi Yang +6 more
doaj +1 more source
Frontiers in Genetics, 2022 Polo-like kinase 4 (PLK4), a key regulator of centriole biogenesis, is frequently overexpressed in cancer cells. However, roles and the mechanism of PLK4 in the leukemiagenesis of acute myeloid leukemia (AML) remain unclear.
Xing-Ru Mu +11 more
doaj +1 more source