Centrosomal protein 120 promotes centrosome amplification and gastric cancer progression via USP54-mediated deubiquitination of PLK4 [PDF]
iScience, 2023 Summary: Centrosomal protein 120 (CEP120) is a 120 kDa centrosome protein that plays an important role in centrosome replication. Overexpression of CEP120 can lead to centrosome duplicate abnormality, which is closely associated with tumorigenesis and ...
Chenggang Zhang +11 more
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Epigenetic alterations impede epithelial-mesenchymal transition by modulating centrosome amplification and Myc/RAS axis in triple negative breast cancer cells [PDF]
Scientific Reports, 2023 Alterations in centrosome proteins may result in centrosome abnormalities such as disorganized spindles and centrosome amplification, leading to aneuploidy and genomic instability.
Laxmidhar Das
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Aggressive uveal melanoma displays a high degree of centrosome amplification, opening the door to therapeutic intervention [PDF]
The Journal of Pathology: Clinical Research, 2022 Uveal melanoma (UM) is the most common intraocular cancer in adults. Whilst treatment of primary UM (PUM) is often successful, around 50% of patients develop metastatic disease with poor outcomes, linked to chromosome 3 loss (monosomy 3, M3). Advances in
Dorota Sabat‐Pośpiech +6 more
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GPER1 links estrogens to centrosome amplification and chromosomal instability in human colon cells [PDF]
Life Science Alliance, 2023 This study reveals a causal link between (xeno)estrogen-activated GPER1, centriole-positive numerical centrosome amplification, and genomic instability in normal colon and colorectal cancer cells.
Miriam Bühler +6 more
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KIFC1 depends on TRIM37-mediated ubiquitination of PLK4 to promote centrosome amplification in endometrial cancer [PDF]
Cell Death DiscoveryEndometrial cancer (EC), as one of the most common cancers, severely threatens female reproductive health. Our previous study has shown that Kinesin family member C1 (KIFC1) played crucial roles in the progression of EC.
Kening Zhou +5 more
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The SH2 domain and kinase activity of JAK2 target JAK2 to centrosome and regulate cell growth and centrosome amplification. [PDF]
PLoS ONE, 2022 JAK2 is cytokine-activated non-receptor tyrosine kinase. Although JAK2 is mainly localized at the plasma membrane, it is also present on the centrosome. In this study, we demonstrated that JAK2 localization to the centrosome depends on the SH2 domain and
Aashirwad Shahi +3 more
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Correction to "The Variant Senescence-Associated Secretory Phenotype Induced by Centrosome Amplification Constitutes a Pathway That Activates Hypoxia-Inducible Factor-1α". [PDF]
Aging CellAging Cell, Volume 25, Issue 6, June 2026.
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Stress adaptation pathways and HA–CD44 signaling maintain the survival of pancreatic cancer cells with centrosome amplification [PDF]
Cell Communication and SignalingCentrosome amplification (CA) is a hallmark of aggressive cancers, including pancreatic ductal adenocarcinoma (PDAC), and is linked to genomic instability and poor prognosis.
Selahattin Can Ozcan +5 more
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TUFT1 regulates cancer progression by suppressing centrosome amplification and mitotic spindle multipolarity [PDF]
Cell Death and DiseaseCentrosome amplification (CA) has been observed in various solid tumors and contributes to chromosomal instability (CIN) and poor clinical prognosis in patients with cancer. CA also inhibits cell proliferation by inducing cell-cycle arrest and cell death.
Shaojie Feng +7 more
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Centrosome amplification and aneuploidy driven by the HIV-1-induced Vpr•VprBP•Plk4 complex in CD4+ T cells [PDF]
Nature CommunicationsHIV-1 infection elevates the risk of developing various cancers, including T-cell lymphoma. Whether HIV-1-encoded proteins directly contribute to oncogenesis remains unknown.
Jung-Eun Park +15 more
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