Results 11 to 20 of about 15,728 (128)

A catalog of numerical centrosome defects in epithelial ovarian cancers

EMBO Molecular Medicine, 2022
Centrosome amplification, the presence of more than two centrosomes in a cell is a common feature of most human cancer cell lines. However, little is known about centrosome numbers in human cancers and whether amplification or other numerical aberrations
Jean‐Philippe Morretton, Anthony Simon, Aurélie Herbette, Jorge Barbazan, Carlos Pérez‐González, Camille Cosson, Bassirou Mboup, Aurélien Latouche, Tatiana Popova, Yann Kieffer, Anne‐Sophie Macé, Pierre Gestraud, Guillaume Bataillon, Véronique Becette, Didier Meseure, André Nicolas, Odette Mariani, Anne Vincent‐Salomon, Marc‐Henri Stern, Fatima Mechta‐Grigoriou, Sergio Roman Roman, Danijela Matic Vignjevic, Roman Rouzier, Xavier Sastre‐Garau, Oumou Goundiam, Renata Basto   +25 more
doaj   +1 more source

Site-specific phosphorylation of ZYG-1 regulates ZYG-1 stability and centrosome number

iScience, 2023
Summary: Spindle bipolarity is critical for genomic integrity. As centrosome number often dictates bipolarity, tight control of centrosome assembly is vital for faithful cell division.
Jeffrey C. Medley, Rachel N. Yim, Joseph DiPanni, Brandon Sebou, Blake Shaffou, Evan Cramer, Colin Wu, Megan Kabara, Mi Hye Song   +8 more
doaj   +1 more source

Centrosome amplification mediates small extracellular vesicle secretion via lysosome disruption

Current Biology, 2021
Gisela D’Angelo, TERESA Arnandis, Hemant M Kocher   +2 more
exaly   +2 more sources

Control of centrin stability by Aurora A. [PDF]

PLoS ONE, 2011
Aurora A is an oncogenic serine/threonine kinase which can cause cell transformation and centrosome amplification when over-expressed. Human breast tumors show excess Aurora A and phospho-centrin in amplified centrosomes.
Kara B Lukasiewicz, Tammy M Greenwood, Vivian C Negron, Amy K Bruzek, Jeffrey L Salisbury, Wilma L Lingle   +5 more
doaj   +1 more source

The fate of extra centrosomes in newly formed tetraploid cells: should I stay, or should I go?

Frontiers in Cell and Developmental Biology, 2023
An increase in centrosome number is commonly observed in cancer cells, but the role centrosome amplification plays along with how and when it occurs during cancer development is unclear. One mechanism for generating cancer cells with extra centrosomes is
Mathew Bloomfield, Daniela Cimini
doaj   +1 more source

The G₁ phase Cdks regulate the centrosome cycle and mediate oncogene-dependent centrosome amplification

Cell Division, 2011
Because centrosome amplification generates aneuploidy and since centrosome amplification is ubiquitous in human tumors, a strong case is made for centrosome amplification being a major force in tumor biogenesis.
Saavedra Harold I, Adon Arsene M, Harrison Mary K   +2 more
doaj   +1 more source

RABL6A, a novel RAB-like protein, controls centrosome amplification and chromosome instability in primary fibroblasts. [PDF]

PLoS ONE, 2013
RABL6A (RAB-like 6 isoform A) is a novel protein that was originally identified based on its association with the Alternative Reading Frame (ARF) tumor suppressor.
Xuefeng Zhang, Jussara Hagen, Viviane P Muniz, Tarik Smith, Gary S Coombs, Christine M Eischen, Duncan I Mackie, David L Roman, Richard Van Rheeden, Benjamin Darbro, Van S Tompkins, Dawn E Quelle   +11 more
doaj   +1 more source

Type 2 Diabetes Promotes Cell Centrosome Amplification via AKT-ROS-Dependent Signalling of ROCK1 and 14-3-3σ

Cellular Physiology and Biochemistry, 2018
Background/Aims: Type 2 diabetes is associated with oxidative stress and DNA damage which can cause centrosome amplification. Thus, the study investigated centrosome amplification in type 2 diabetes and the underlying mechanisms.
Pu Wang, Yu Cheng Lu, Jie Wang, Lan Wang, Hanry Yu, Yuan Fei Li, Alice Kong, Juliana Chan, Shaochin Lee   +8 more
doaj   +1 more source

Cigarette smoke condensate induces centrosome clustering in normal lung epithelial cells

Cancer Medicine, 2023
Background Unlike normal cells, cancer cells frequently have multiple centrosomes that can cluster to form bipolar mitotic spindles and allow for successful cell division.
Jose Thaiparambil, Chandra S. Amara, Subrata Sen, Nagireddy Putluri, Randa El‐Zein   +4 more
doaj   +1 more source

The centrosome and cell proliferation

Cell Division, 2006
Centrosomes are frequently amplified in cancer cells. Increased numbers of centrosomes can give rise to multipolar spindles in mitosis, and thereby lead to the formation of aneuploid daughter cells. However, whether centrosome amplification is a cause or
Merdes Andreas, Srsen Vlastimil
doaj   +1 more source