Results 21 to 30 of about 15,728 (128)

FancJ regulates interstrand crosslinker induced centrosome amplification through the activation of polo-like kinase 1

Biology Open, 2013
Summary DNA damage response (DDR) and the centrosome cycle are two of the most critical processes for maintaining a stable genome in animals. Sporadic evidence suggests a connection between these two processes.
Jianqiu Zou, Fen Tian, Ji Li, Wyatt Pickner, Molly Long, Khosrow Rezvani, Hongmin Wang, Dong Zhang   +7 more
doaj   +1 more source

Centrosome loss or amplification does not dramatically perturb global gene expression in Drosophila

Biology Open, 2012
Summary Centrosome defects are a common feature of many cancers, and they can predispose fly brain cells to form tumours. In flies, centrosome defects perturb the asymmetric division of the neural stem cells, but it is unclear how this might lead to ...
Janina Baumbach, Mitchell P. Levesque, Jordan W. Raff   +2 more
doaj   +1 more source

Simultaneous Aurora-A/STK15 overexpression and centrosome amplification induce chromosomal instability in tumour cells with a MIN phenotype

BMC Cancer, 2007
Background Genetic instability is a hallmark of tumours and preneoplastic lesions. The predominant form of genome instability in human cancer is chromosome instability (CIN).
Schillaci Tiziana, Amato Angela, Lentini Laura, Di Leonardo Aldo   +3 more
doaj   +1 more source

The PIDDosome: centrosome guardian and backup on the DNA damage response

Molecular & Cellular Oncology, 2021
The PIDDosome is a Caspase-2-activating platform assembling in response to centrosome amplification or genotoxic stress. We have recently shown that both stimuli depend on ANKRD26 (ankyrin repeat domain-containing protein 26)-mediated localization of ...
Matteo Burigotto, Luca L. Fava
doaj   +1 more source

HTLV-1 Tax: centrosome amplification and cancer

Retrovirology, 2006
During interphase, each cell contains a single centrosome that acts as a microtubule organizing center for cellular functions in interphase and in mitosis.
Kashanchi Fatah, de la Fuente Cynthia, Pumfery Anne   +2 more
doaj   +1 more source

RB acute loss induces centrosome amplification and aneuploidy in murine primary fibroblasts

Molecular Cancer, 2006
Background Incorrect segregation of whole chromosomes or parts of chromosome leads to aneuploidy commonly observed in cancer. The correct centrosome duplication, assuring assembly of a bipolar mitotic spindle, is essential for chromosome segregation ...
Amato Angela, Lentini Laura, Iovino Flora, Di Leonardo Aldo   +3 more
doaj   +1 more source

An IKKα-Nucleophosmin Axis Utilizes Inflammatory Signaling to Promote Genome Integrity

Cell Reports, 2013
The inflammatory microenvironment promotes skin tumorigenesis. However, the mechanisms by which cells protect themselves from inflammatory signals are unknown.
Xiaojun Xia, Shuang Liu, Zuoxiang Xiao, Feng Zhu, Na-Young Song, Ming Zhou, Bigang Liu, Jianjun Shen, Kunio Nagashima, Timothy D. Veenstra, Sandra Burkett, Mahesh Datla, Jami Willette-Brown, Haifa Shen, Yinling Hu   +14 more
doaj   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Chromosomal Instability Drives Glioblastoma Heterogeneity and Therapeutic Opportunities

Advanced Science, EarlyView.
ABSTRACT Glioblastoma, the most aggressive and lethal form of brain cancer, is defined by profound genomic instability, with Chromosomal Instability (CIN) playing a central role in driving tumor progression, therapy resistance, and poor prognosis. CIN is characterized by numerical and structural alterations, is driven by mechanisms such as mitotic ...
Amarnath Pal, Milan Patra, Rianita Mondal, Shubhasis Haldar   +3 more
wiley   +1 more source

A novel role of the aryl hydrocarbon receptor (AhR) in centrosome amplification - implications for chemoprevention

Molecular Cancer, 2010
Background Centrosome aberrations can cause genomic instability and correlate with malignant progression in common human malignancies such as breast and prostate cancer. Deregulation of cyclin/cyclin-dependent kinase 2 (CDK2) activity has previously been
Chatterjee Payel, Wheeler Sarah, Korzeniewski Nina, Duensing Anette, Duensing Stefan   +4 more
doaj   +1 more source