Results 21 to 30 of about 4,153 (193)

Polo-like Kinase 4: A Molecular Culprit in Skin Cancer Pathogenesis [PDF]

Cells
Skin cancer remains a significant global health challenge, with rising incidence and associated mortality in late-stage and drug-resistant cases. This underscores a continuing need for more effective novel therapeutic options that can be utilized for ...
Tanya Jaiswal, Durdana Muntaqua, Nihal Ahmad   +2 more
doaj   +2 more sources

Polo-like kinases and UV-induced skin carcinogenesis: What we know and what's next. [PDF]

Photochem Photobiol
The polo‐like kinase (PLK) family plays distinct and critical roles in the regulation of cell cycle progression, and its dysregulation has been implicated in various cancers. Ultraviolet (UV) radiation is a well‐established environmental factor in the development of skin cancer.
Jaiswal T, Muntaqua D, Chhabra G, Ahmad N.   +3 more
europepmc   +2 more sources

PLK4: Master Regulator of Centriole Duplication and Its Therapeutic Potential. [PDF]

Cytoskeleton (Hoboken)
ABSTRACT Centrosomes catalyze the assembly of a microtubule‐based bipolar spindle, essential for the precise chromosome segregation during cell division. At the center of this process lies Polo‐Like Kinase 4 (PLK4), the master regulator that controls the duplication of the centriolar core to ensure the correct balance of two centrosomes per dividing ...
Hamzah M, Meitinger F, Ohta M.
europepmc   +2 more sources

Discovery of novel dual-targeting inhibitors against PLK1-PBD and PLK4-PB3: structure-guided pharmacophore modelling, virtual screening, molecular docking, molecular dynamics simulation, and biological evaluation [PDF]

Journal of Enzyme Inhibition and Medicinal Chemistry
Aberrant expression of PLK1 and PLK4 is closely associated with tumourigenesis, and their simultaneous inhibition can effectively suppress tumour proliferation.
Changhao Zhao, Hanying Wu, Huajing Liu, Hui Dong, Miao-Miao Niu, Kun Shi, Fengzhen Wang   +6 more
doaj   +2 more sources

Target Binding of Black Phosphorus Nanomaterial to Polo-Like Kinase 1 for Cancer Chemotherapy: A Mutual Selection of Nanomaterial and Protein. [PDF]

Exploration (Beijing)
This study investigates the effect of protein properties on the nanomaterial‐protein interaction and elucidates the molecular mechanisms underlying the targeted inhibition of polo‐like kinase (PLK1) by black phosphorus nanomaterials (BPNMs). The specific targeting inhibition is attributed to the intrinsic properties of both the PLK1 protein and the ...
Liu F, Li ZD, Zeng Y, Wang X, Liu Y, Li Q, Luo W, Suo X, Xu Y, Yuan F, Zhang D, Zhang W, Geng S, Yu XF, Zhang G, Li Y.   +15 more
europepmc   +2 more sources

Polo-Like Kinase 4 (PLK4) Is Overexpressed in Central Nervous System Neuroblastoma (CNS-NB)

Bioengineering, 2018
Neuroblastoma (NB) is the most common extracranial solid tumor in pediatrics, with rare occurrences of primary and metastatic tumors in the central nervous system (CNS).
Anders W. Bailey, Amreena Suri, Pauline M. Chou, Tatiana Pundy, Samantha Gadd, Stacey L. Raimondi, Tadanori Tomita, Simone Treiger Sredni   +7 more
doaj   +2 more sources

Cep152 acts as a scaffold for recruitment of Plk4 and CPAP to the centrosome [PDF]

Journal of Cell Biology, 2010
Both gain and loss of function studies have identified the Polo-like kinase Plk4/Sak as a crucial regulator of centriole biogenesis, but the mechanisms governing centrosome duplication are incompletely understood. In this study, we show that the pericentriolar material protein, Cep152, interacts with the distinctive cryptic Polo-box of Plk4 via its N ...
Cizmecioglu, Onur, Arnold, Marc, Bahtz, Ramona, Settele, Florian, Ehret, Lena, Haselmann-Weiß, Uta, Antony, Claude, Hoffmann, Ingrid   +7 more
openaire   +3 more sources

Prolonged overexpression of PLK4 leads to formation of centriole rosette clusters that are connected via canonical centrosome linker proteins

Scientific Reports
Centrosome amplification is a hallmark of cancer and PLK4 is one of the responsible factors for cancer associated centrosome amplification. Increased PLK4 levels was also shown to contribute to generation of cells with centriole amplification in ...
Batuhan Mert Kalkan, Ceyda Acilan, Acilan Ceyda   +2 more
exaly   +2 more sources

Gene expression patterns in heterozygous Plk4 murine embryonic fibroblasts [PDF]

BMC Genomics, 2009
Background The polo-like kinases (Plks) are a group of serine/threonine kinases which have roles in many aspects of cellular function including the regulation of mitotic activity and cellular stress responses.
Nantais Jordan, Ward Alejandra, Morettin Alan, Hudson John W   +3 more
doaj   +3 more sources

Centriole Duplication: When PLK4 Meets Ana2/STIL [PDF]

Current Biology, 2014
Polo-like kinase 4 is known to drive centriole duplication, but the relevant substrate remains elusive. A new study shows that PLK4 phosphorylates a key centriolar component, Ana2/STIL, to initiate centriole assembly.
Kim, Minhee, Fong, Chii Shyang, Bryan Tsou, Meng-Fu   +2 more
openaire   +3 more sources