Results 21 to 30 of about 905 (118)
Regulation of Autophosphorylation Controls PLK4 Self-Destruction and Centriole Number [PDF]
, 2013 SummaryPolo-like kinase 4 (PLK4) is a major player in centriole biogenesis: in its absence centrioles fail to form, while in excess leads to centriole amplification [1–5].
Debski, Janusz +13 more
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Downregulation of polo-like kinase 4 in hepatocellular carcinoma associates with poor prognosis. [PDF]
PLoS ONE, 2012 Polo-like kinase 4 (PLK4), belonging to serine/threonine kinase family, is critical for centriole replication and cell cycle progression. PLK4 has been proposed as a tumor suppressor in hepatocellular carcinoma (HCC).
Lili Liu +5 more
doaj +1 more source
Mechanistic study on PLK4 regulation of invasion, proliferation and apoptosis in oral squamous cell carcinoma [PDF]
Zhongguo aizheng zazhiBackground and purpose: Polo-like kinase 4 (PLK4) is a cell cycle regulatory protein, which is closely related to the occurrence and development of a variety of malignant tumors.
QIN Huan, WANG Jie, YANG Jie, HUA Yingjie, QU Huijuan, JI Honghai
doaj +3 more sources
Consequences of Plk4 overexpression in mouse pancreatic organoids [PDF]
, 2021 Overexpression of the polo-like kinase 4 (Plk4), the master regulator of centrosome duplication, leads to centrosome amplification, a common feature of cancer, including pancreatic cancer.
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Global cellular response to chemical perturbation of PLK4 activity and abnormal centrosome number
eLife, 2022 Centrosomes act as the main microtubule organizing center (MTOC) in metazoans. Centrosome number is tightly regulated by limiting centriole duplication to a single round per cell cycle.
Johnny M Tkach +5 more
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TRIM37 controls cancer-specific vulnerability to PLK4 inhibition [PDF]
, 2020 Centrosomes catalyse the formation of microtubules needed to assemble the mitotic spindle apparatus1. Centrosomes themselves duplicate once per cell cycle, in a process that is controlled by the serine/threonine protein kinase PLK4 (refs. 2,3). When PLK4
Watanabe, Sadanori +10 more
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The regulation of PLK4 stability by CIP2A
, 2023 The overexpression of cancerous inhibitor of protein phosphatase 2A (CIP2A), a 90kDa oncoprotein, is observed in several human cancer and correlated with cancer progression.
이수빈
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Cell Death and Disease, 2023 Polo-like kinase 4 (Plk4), the major regulator of centriole biogenesis, has emerged as a putative therapeutic target in cancer due to its abnormal expression in human carcinomas, leading to centrosome number deregulation, mitotic defects and chromosomal ...
Irina Fonseca +6 more
doaj +1 more source
, 2006 Plk4, formerly known as Sak, is a member of the polo-like family of kinases (Plks). In recent years, the Plks have emerged as critical regulators of cellular division.
Ko, Michael Augustine
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CRL4 DCAF1 ubiquitin ligase regulates PLK4 protein levels to prevent premature centriole duplication
Life Science AllianceThis study identifies the E3 ubiquitin ligase, CRL4DCAF1, as a new regulator of polo-like kinase 4, PLK4, protein levels in the G2 phase of the cell cycle to prevent premature duplication of centrioles.
Josina Grossmann +4 more
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