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Consequences of Plk4 overexpression in mouse pancreatic organoids
, 2021 Overexpression of the polo-like kinase 4 (Plk4), the master regulator of centrosome duplication, leads to centrosome amplification, a common feature of cancer, including pancreatic cancer. Previous studies have shown that overexpression of Plk4 in mice carrying a doxycycline-inducible Plk4 transgene (Plk4OE) causes centrosome amplification, a reduction
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The Polo kinase Plk4 functions in centriole duplication
Nature Cell Biology, 2005 The human Polo-like kinase 1 (PLK1) and its functional homologues that are present in other eukaryotes have multiple, crucial roles in meiotic and mitotic cell division. By contrast, the functions of other mammalian Polo family members remain largely unknown.
Habedanck, Robert +3 more
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Plk4 Phosphorylates Ana2 to Trigger Sas6 Recruitment and Procentriole Formation [PDF]
Current Biology, 2014 Centrioles are 9-fold symmetrical structures at the core of centrosomes and base of cilia whose dysfunction has been linked to a wide range of inherited diseases and cancer. Their duplication is regulated by a protein kinase of conserved structure, the C. elegans ZYG-1 or its Polo-like kinase 4 (Plk4) counterpart in other organisms.
Dzhindzhev N. S. +8 more
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Polo-like kinase 4 as a potential predictive biomarker of chemoradioresistance in locally advanced rectal cancer [PDF]
Journal of Pathology and Translational Medicine, 2022 Background Polo-like kinase 4 (PLK4) is a serine/threonine protein kinase located in the centriole of the chromosome during the cell cycle. PLK4 overexpression has been described in a variety of many common human epithelial tumors.
Hyunseung Oh +8 more
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Sak/Plk4 and mitotic fidelity [PDF]
Oncogene, 2005 Sak/Plk4 differs from other polo-like kinases in having only a single polo box, which assumes a novel dimer fold that localizes to the nucleolus, centrosomes and the cleavage furrow. Sak expression increases gradually in S through M phase, and Sak is destroyed by APC/C dependent proteolysis.
Carol J, Swallow +4 more
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Plk4-induced Centriole Biogenesis in Human Cells [PDF]
, 2008 Kleylein-Sohn, Julia, Kleylein-Sohn, J.
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Fast and furious . . . or not, Plk4 dictates the pace [PDF]
Journal of Cell Biology, 2018 In each duplication cycle, daughter centrioles grow to the same length as their mothers. Which mechanisms regulate this fidelity to maintain centriole length is not known. In this issue, Aydogan et al. (2018. J. Cell Biol. https://doi.org/10.1083/jcb.201801014) report a novel role for Polo-like kinase 4 (Plk4).
Gemble, Simon, Basto, Renata
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Use of the Polo-like kinase 4 (PLK4) inhibitor centrinone to investigate intracellular signalling networks using SILAC-based phosphoproteomics [PDF]
, 2020 Polo-like kinase 4 (PLK4) is the master regulator of centriole duplication in metazoan organisms. Catalytic activity and protein turnover of PLK4 are tightly coupled in human cells, since changes in PLK4 concentration and catalysis have profound effects ...
Jones, Andrew R +9 more
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FEBS Open Bio, 2021 Polo‐like kinase 4 (PLK4) has been reported to contribute to tumor growth, invasion, and metastasis. However, the role of PLK4 in human bladder cancer (BC) remains unclear.
Ziyi Yang +6 more
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Cell Death and Disease, 2021 Polo-like kinase 4 (PLK4), a key regulator of centriole biogenesis, has recently been shown to play key roles in tumorigenesis. Blocking PLK4 expression by interference or targeted drugs exhibits attractive potential in improving the efficacy of ...
Yi Zhao +8 more
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