Results 31 to 40 of about 905 (118)

A simple Turing reaction-diffusion model explains how PLK4 breaks symmetry during centriole duplication and assembly [PDF]

, 2023
Centrioles duplicate when a mother centriole gives birth to a daughter that grows from its side. Polo-like-kinase 4 (PLK4), the master regulator of centriole duplication, is recruited symmetrically around the mother centriole, but it then concentrates at
Wilmott, Zac, Goriely, Alain, Raff, Jordan   +2 more
core   +1 more source

Polo-like kinase 4: A molecular linchpin in cancer and its management

iScience
Summary: Genomic instability and cell cycle dysregulation are considered hallmarks of cancer. Polo-like kinase 4 (PLK4), a member of the PLK family, is essential for faithful centriole duplication, which, when dysregulated, contributes to genomic ...
Durdana Muntaqua, Gagan Chhabra, Karla B. Anaya Aldrete, Nihal Ahmad   +3 more
doaj   +1 more source

A Bright Ratiometric Dipyrene Probe for Functional Imaging of Condensate Microenvironments in Living Cells

Advanced Science, Volume 13, Issue 54, 28 September 2026.
Ratiometric dipyrene imaging resolves monomer (M) and excimer (E) channels and computes pixel‐wise E/M maps within biomolecular condensates, yielding physicochemical fingerprints shaped by coupled polarity‐related solvation and microviscosity. These spatial fingerprints enable quantitative phenotyping of cellular states, exemplified by separation of ...
Koki Matsumoto, Sora Kitai, Yoshio Nishiyama, Shogo Amemori, Kei Makiyama, Dini Kurnia Ikliptikawati, Kentaro Ohira, Yuta Kozuka, Maho Tobita, Shih‐Cheng Chen, Chien‐Hung Yu, Wei‐Min Liu, De‐Chen Lin, Motohiro Mizuno, Kazuma Ogawa, Koichi Ogami, Kenji Takahashi, Hiroshi I. Suzuki, Richard W. Wong, Takahiro Soeta, Masaharu Hazawa   +20 more
wiley   +1 more source

Characterizing hematological and reproductive phenotypes in the Plk4+/– mouse

, 2022
The polo-like kinases (Plks) are a family of serine/threonine kinases, of which there are five members. These protein kinases are involved in a multitude of processes associated with the cell cycle.
LaBute, Brayden
core   +1 more source

Organoids in Precision Radiotherapy: Methodological Foundations, Tumor‐Specific Evidence, and Translational Roadmaps

Cancer Medicine, Volume 15, Issue 9, September 2026.
ABSTRACT Background Radiotherapy remains a cornerstone of cancer treatment, while its efficacy is often limited by tumor radioresistance and the risk of normal tissue toxicity. Conventional preclinical models, including two‐dimensional (2D) cell cultures and murine xenografts, exhibit significant limitations in recapitulating human tumor ...
Yixian Zhu, Yawei Jiao, Jiao Xue, Xiaoli Lv, Songbing Qin   +4 more
wiley   +1 more source

Polo-like kinase 4: the odd one out of the family

Cell Division, 2010
Polo-like kinase 4 (PLK4) is a unique member of the Polo-like family of kinases that shares little homology with its siblings and has an essential role in centriole duplication.
Bornens Michel, Sillibourne James E
doaj   +1 more source

Investigating the Functions of PLK4 in Epigenetic Regulation [PDF]

, 2021
PLK4 is a serine/threonine kinase known to be involved in cell cycle regulation and centrosome duplication. Its protein levels are tightly regulated in order to prevent centrosome irregularities that would lead to aneuploidy and eventual oncogenesis ...
Tran, Necky
core   +1 more source

Cep152 interacts with Plk4 and is required for centriole duplication [PDF]

, 2010
Centrioles are microtubule-based structures that organize the centrosome and nucleate cilia. Centrioles duplicate once per cell cycle, and duplication requires Plk4, a member of the Polo-like kinase family; however, the mechanism linking Plk4 activity ...
Kulukian, Anita, Holland, Andrew J, Emily M. Hatch, Don W. Cleveland, Tim Stearns, Cleveland, Don W, Stearns, Tim, Andrew J. Holland, Anita Kulukian, Hatch, Emily M   +9 more
core   +1 more source

Chromosomal Instability Drives Glioblastoma Heterogeneity and Therapeutic Opportunities

Advanced Science, Volume 13, Issue 39, 13 July 2026.
ABSTRACT Glioblastoma, the most aggressive and lethal form of brain cancer, is defined by profound genomic instability, with Chromosomal Instability (CIN) playing a central role in driving tumor progression, therapy resistance, and poor prognosis. CIN is characterized by numerical and structural alterations, is driven by mechanisms such as mitotic ...
Amarnath Pal, Milan Patra, Rianita Mondal, Shubhasis Haldar   +3 more
wiley   +1 more source

High expression of polo-like kinase 4 predicts worse progression-free survival in diffuse large B cell lymphoma patients treated with R-CHOP

World Journal of Surgical Oncology
Background Polo-like kinase 4 (PLK4) has been shown to be a tumor-promoting factor with multiple impacts on cancer growth, invasiveness, and treatment sensitivity.
Dehong Xu, Qijie Ran, Biao Xu, Qi Wang, Tao Geng   +4 more
doaj   +1 more source