Results 51 to 60 of about 4,153 (193)

Plk4 is required for cytokinesis and maintenance of chromosomal stability [PDF]

Proceedings of the National Academy of Sciences, 2010
Aneuploidy is a characteristic feature of established cancers and can promote tumor development. Aneuploidy may arise directly, through unequal distribution of chromosomes into daughter cells, or indirectly, through a tetraploid intermediate.
Carla O, Rosario, Michael A, Ko, Yosr Z, Haffani, Rebecca A, Gladdy, Jana, Paderova, Aaron, Pollett, Jeremy A, Squire, James W, Dennis, Carol J, Swallow   +8 more
openaire   +2 more sources

Global cellular response to chemical perturbation of PLK4 activity and abnormal centrosome number

eLife, 2022
Centrosomes act as the main microtubule organizing center (MTOC) in metazoans. Centrosome number is tightly regulated by limiting centriole duplication to a single round per cell cycle.
Johnny M Tkach, Reuben Philip, Amit Sharma, Jonathan Strecker, Daniel Durocher, Laurence Pelletier   +5 more
doaj   +1 more source

The E3 ubiquitin ligase Mib1 regulates Plk4 and centriole biogenesis [PDF]

, 2015
Centrioles function as core components of centrosomes and as basal bodies for the formation of cilia and flagella. Thus, effective control of centriole numbers is essential for embryogenesis, tissue homeostasis, and genome stability.
Glatter, Timo, Cajanek, Lukas, Nigg, Erich A.   +2 more
core   +2 more sources

Polo-like kinase 4 (Plk4) potentiates anoikis-resistance of p53KO mammary epithelial cells by inducing a hybrid EMT phenotype

Cell Death and Disease, 2023
Polo-like kinase 4 (Plk4), the major regulator of centriole biogenesis, has emerged as a putative therapeutic target in cancer due to its abnormal expression in human carcinomas, leading to centrosome number deregulation, mitotic defects and chromosomal ...
Irina Fonseca, Cíntia Horta, Ana Sofia Ribeiro, Barbara Sousa, Gaëlle Marteil, Mónica Bettencourt-Dias, Joana Paredes   +6 more
doaj   +1 more source

SAK/PLK4 Is Required for Centriole Duplication and Flagella Development [PDF]

Current Biology, 2005
SAK/PLK4 is a distinct member of the polo-like kinase family. SAK-/- mice die during embryogenesis, whereas SAK+/- mice develop liver and lung tumors and SAK+/- MEFs show mitotic abnormalities. However, the mechanism underlying these phenotypes is still not known.Here, we show that downregulation of SAK in Drosophila cells, by mutation or RNAi, leads ...
BETTENCOURT DIAS M., RODRIGUES MARTINS A., CARPENTER L., RIPARBELLI, MARIA GIOVANNA, LEHMANN L., GATT M. K., CARMO N., BALLOUX, CALLAINI, GIULIANO, GLOVER D. M.   +9 more
openaire   +5 more sources

CRL4 DCAF1 ubiquitin ligase regulates PLK4 protein levels to prevent premature centriole duplication

Life Science Alliance
This study identifies the E3 ubiquitin ligase, CRL4DCAF1, as a new regulator of polo-like kinase 4, PLK4, protein levels in the G2 phase of the cell cycle to prevent premature duplication of centrioles.
Josina Grossmann, Anne-Sophie Kratz, Alina Kordonsky, Gali Prag, Ingrid Hoffmann   +4 more
doaj   +1 more source

The use of deidentified organ donor testes for research

Andrology, EarlyView.
Abstract Our knowledge of testis development and function mainly comes from research using mammalian model organisms, primarily the mouse. However, there are integral differences between men and other mammalian species regarding cellular composition and expression profiles during fetal and post‐natal testis development and in the mature testis ...
Marina V. Pryzhkova, Marnie W. Skinner, Juliana I. Candelaria, Stephen R. Wellard, Philip W. Jordan   +4 more
wiley   +1 more source

Polo-like kinase 4: the odd one out of the family

Cell Division, 2010
Polo-like kinase 4 (PLK4) is a unique member of the Polo-like family of kinases that shares little homology with its siblings and has an essential role in centriole duplication.
Bornens Michel, Sillibourne James E
doaj   +1 more source

NuSAP Safeguards Centriole Integrity to Mediate CEP57‐CEP152 Torus Recruitment for Proper Engagement

Advanced Science, Volume 13, Issue 19, 2 April 2026.
This study reveals a novel role for the microtubule stabilizer NuSAP at centrioles. NuSAP depletion destabilizes the centriole's tubulin structure, causing premature disengagement, PCM defects, and mis‐localization of the CEP57‐CEP63‐CEP152 complex. By reinforcing centriole architecture, NuSAP enables early CEP57 loading and initiates a newly proposed ...
Shiyu Zhang, Zemin Jiang, Qiaoyun Yang, Hong Zheng, Minghao Wang, Chennianci Zhu, Lih‐Wen Deng, Karen Carmelina Crasta, Yih‐Cherng Liou   +8 more
wiley   +1 more source

Plk4/SAK/ZYG-1 in the regulation of centriole duplication [PDF]

F1000 Biology Reports, 2010
Centrioles organize both centrosomes and cilia. Centriole duplication is tightly regulated and coordinated with the cell cycle to limit duplication to only once per cell cycle. Defects in centriole number and structure are commonly found in cancer. Plk4/SAK and the functionally related Caenorhabditis elegans ZYG-1 kinases initiate centriole duplication.
Pearson, Chad G, Winey, Mark
openaire   +2 more sources