Results 51 to 60 of about 905 (118)

The expression of PLK4 in colorectal cancer and its clinical significance

Zhongguo aizheng zazhi, 2018
Background and purpose: Polo-like kinase 4 (PLK4) is mainly involved in regulation of the replication process of centrosome. Overexpression of PLK4 can induce the enlargement of the centrosome, cause instability of the chromosomes, and enhance tumor ...
蒋浩海, 肖　锋, 顾春燕
doaj  

Migrasome-mediated clearance of excess PLK4 defines a targetable vulnerabilityResearch in context

EBioMedicine
Summary: Background: Centrosome amplification caused by Polo-like kinase 4 (PLK4) overexpression promotes tumour initiation, yet sustained PLK4 accumulation is detrimental to cancer cell viability.
Jihong Ma, Yuhan Guo, Yuening Jiang, Qilong Wang, Meiyu Bi, Tianzhen Wang, Yinan Xiao, Na Zhang, Pan Wang, Yu Wu, Bingteng Xie, Gang Wang, Mo Li   +12 more
doaj   +1 more source

Over-expression of Plk4 induces centrosome amplification, loss of primary cilia and associated tissue hyperplasia in the mouse [PDF]

Open Biology, 2015
To address the long-known relationship between supernumerary centrosomes and cancer, we have generated a transgenic mouse that permits inducible expression of the master regulator of centriole duplication, Polo-like-kinase-4 (Plk4).
Paula A. Coelho, Leah Bury, Marta N. Shahbazi, Kifayathullah Liakath-Ali, Peri H. Tate, Sam Wormald, Christopher J. Hindley, Meritxell Huch, Joy Archer, William C. Skarnes, Magdalena Zernicka-Goetz, David M. Glover   +11 more
doaj   +1 more source

Apolipoprotein E Deficiency Impairs Human Microglial Proliferation Accompanied by Elevated Cellular Oxidative Stress

Journal of Cellular and Molecular Medicine, Volume 30, Issue 6, March 2026.
ABSTRACT The APOE gene, which encodes Apolipoprotein E (ApoE), is the strongest genetic risk locus for Alzheimer's disease (AD). A substantial fraction of AD risk genes converges on pathways controlling lipid metabolism and immune regulation, in which microglia serve as a central integrative hub in the brain.
Dayoung Kim, Takayuki Kondo, Keiko Imamura, Kayoko Tsukita, Ayako Nagahashi, Tomoki Sakasai, Haruhisa Inoue   +6 more
wiley   +1 more source

PLK4 drives centriole amplification and apical surface area expansion in multiciliated cells

eLife, 2022
Multiciliated cells (MCCs) are terminally differentiated epithelia that assemble multiple motile cilia used to promote fluid flow. To template these cilia, MCCs dramatically expand their centriole content during a process known as centriole amplification.
Gina M LoMastro, Chelsea G Drown, Aubrey L Maryniak, Cayla E Jewett, Margaret A Strong, Andrew Jon Holland   +5 more
doaj   +1 more source

Polo‐like kinases and UV‐induced skin carcinogenesis: What we know and what's next

Photochemistry and Photobiology, Volume 102, Issue 2, Page 276-289, March/April 2026.
The polo‐like kinase (PLK) family plays distinct and critical roles in the regulation of cell cycle progression, and its dysregulation has been implicated in various cancers. Ultraviolet (UV) radiation is a well‐established environmental factor in the development of skin cancer.
Tanya Jaiswal, Durdana Muntaqua, Gagan Chhabra, Nihal Ahmad   +3 more
wiley   +1 more source

Centrosomal JAK2 Tyrosine Kinase Regulates Primary Cilia Length, Cell Proliferation, and Cilia Orientation During Cell Migration

The FASEB Journal, Volume 40, Issue 4, 28 February 2026.
Growth hormone (GH) activates GHR at the primary cilium and stimulates centrosomal JAK2. JAK2 centrosomal localization requires both its SH2 domain and kinase activity. Cells expressing JAK2 variants deficient in centrosomal targeting show impaired control of cilia length, reduced proliferation, and cell migration compared with parental and JAK2 WT ...
Gaurab Karki, Lilly Boone, Taylor Klaiber, Trevor Lambert, Brooke Kimball, Bethany Burkhart, Mirella Youssef, Maria Diakonova   +7 more
wiley   +1 more source

Synthetic lethality in cancer therapy: Mechanisms, models and clinical translation for overcoming therapeutic resistance

Clinical and Translational Medicine, Volume 16, Issue 1, January 2026.
Application of synthetic lethality screening in drug resistance models. Abstract Background and Rationale Synthetic lethality (SL)‐based strategies hold significant promise for overcoming therapeutic resistance, a critical bottleneck in cancer treatment where cancer cells evade anticancer therapies, leading to diminished efficacy or treatment failure ...
Junyan Li, Liyuan Zhang, Yan Shang, Juan Liu, Hailong Zhao   +4 more
wiley   +1 more source

Gene expression patterns in heterozygous Plk4 murine embryonic fibroblasts

BMC Genomics, 2009
Background The polo-like kinases (Plks) are a group of serine/threonine kinases which have roles in many aspects of cellular function including the regulation of mitotic activity and cellular stress responses.
Nantais Jordan, Ward Alejandra, Morettin Alan, Hudson John W   +3 more
doaj   +1 more source

CDK11(p58) is required for centriole duplication and Plk4 recruitment to mitotic centrosomes. [PDF]

PLoS ONE, 2011
BACKGROUND: CDK11(p58) is a mitotic protein kinase, which has been shown to be required for different mitotic events such as centrosome maturation, chromatid cohesion and cytokinesis.
Nathalie Franck, Emilie Montembault, Pierre Romé, Aude Pascal, Jean-Yves Cremet, Régis Giet   +5 more
doaj   +1 more source