Results 71 to 80 of about 4,153 (193)
Cancer Cell International, 2020 Background Long noncoding RNA small nucleolar RNA host gene 16 (lncRNA SNHG16) has been revealed to be involved in the tumorigenesis of neuroblastoma.
Zhaoying Xu +4 more
doaj +1 more source
Over-expression of Plk4 induces centrosome amplification, loss of primary cilia and associated tissue hyperplasia in the mouse [PDF]
Open Biology, 2015 To address the long-known relationship between supernumerary centrosomes and cancer, we have generated a transgenic mouse that permits inducible expression of the master regulator of centriole duplication, Polo-like-kinase-4 (Plk4).
Paula A. Coelho +11 more
doaj +1 more source
PLK4 drives centriole amplification and apical surface area expansion in multiciliated cells
eLife, 2022 Multiciliated cells (MCCs) are terminally differentiated epithelia that assemble multiple motile cilia used to promote fluid flow. To template these cilia, MCCs dramatically expand their centriole content during a process known as centriole amplification.
Gina M LoMastro +5 more
doaj +1 more source
The FASEB Journal, Volume 40, Issue 4, 28 February 2026.Growth hormone (GH) activates GHR at the primary cilium and stimulates centrosomal JAK2. JAK2 centrosomal localization requires both its SH2 domain and kinase activity. Cells expressing JAK2 variants deficient in centrosomal targeting show impaired control of cilia length, reduced proliferation, and cell migration compared with parental and JAK2 WT ...
Gaurab Karki +7 more
wiley +1 more source
Characterizing hematological and reproductive phenotypes in the Plk4+/– mouse
, 2022 The polo-like kinases (Plks) are a family of serine/threonine kinases, of which there are five members. These protein kinases are involved in a multitude of processes associated with the cell cycle.
LaBute, Brayden
core
The expression of PLK4 in colorectal cancer and its clinical significance
Zhongguo aizheng zazhi, 2018 Background and purpose: Polo-like kinase 4 (PLK4) is mainly involved in regulation of the replication process of centrosome. Overexpression of PLK4 can induce the enlargement of the centrosome, cause instability of the chromosomes, and enhance tumor ...
蒋浩海, 肖 锋, 顾春燕
doaj
Clinical and Translational Medicine, Volume 16, Issue 1, January 2026.Application of synthetic lethality screening in drug resistance models. Abstract Background and Rationale Synthetic lethality (SL)‐based strategies hold significant promise for overcoming therapeutic resistance, a critical bottleneck in cancer treatment where cancer cells evade anticancer therapies, leading to diminished efficacy or treatment failure ...
Junyan Li +4 more
wiley +1 more source
Lysine demethylase 4A: from chromatin to centrosomes
The FEBS Journal, Volume 293, Issue 2, Page 392-395, January 2026.The lysine demethylase 4A (KDM4A) remodels chromatin by histone demethylation, regulating gene expression. In this issue, Chowdhury et al. report a previously undescribed localisation for KDM4A outside the nucleus, at the pericentriolar material around the centrosome.
Anushka Sharma +2 more
wiley +1 more source
Molecular Cancer, 2011 Background Infection with high-risk human papillomaviruses (HPVs) such as HPV-16 is intimately associated with squamous cell carcinomas (SCCs) of the anogenital tract and a subset of oropharyngeal carcinomas.
Duensing Stefan +2 more
doaj +1 more source
CDK11(p58) is required for centriole duplication and Plk4 recruitment to mitotic centrosomes. [PDF]
PLoS ONE, 2011 BACKGROUND: CDK11(p58) is a mitotic protein kinase, which has been shown to be required for different mitotic events such as centrosome maturation, chromatid cohesion and cytokinesis.
Nathalie Franck +5 more
doaj +1 more source