Results 81 to 90 of about 4,153 (193)

Analysis of Autophagy‐Related Gene Signature Associated With Clinical Prognosis and Immune Microenvironment in Colorectal Cancer

Mediators of Inflammation, Volume 2026, Issue 1, 2026.
Background Autophagy has a critical involvement in the initiation and progression of various cancers, including colorectal cancer (CRC). The feasibility of using autophagy‐related genes (ATGs) as prognostic tools for CRC patients is yet to be determined.
Dazhuang Miao, Yushui Song, Liang Zhou, Guanying Liang, Yan Wang, Wei He, Luyu Huang, Hongnan Lu, Shixiong Jiang, Yunhe Jia, Zhiwei Li, Jinxue Tong, Jasbir Arora (RSS)   +12 more
wiley   +1 more source

Cep152 and Plk4 form a double act [PDF]

Journal of Cell Biology, 2010
Two centrosomal proteins work together to duplicate centrioles.
openaire   +1 more source

Phase Separation of PHLDB2 Drives EMT and Tumor Progression in Triple‐Negative Breast Cancer

Cancer Medicine, Volume 14, Issue 23, December 2025.
ABSTRACT Background Liquid–liquid phase separation (LLPS) has emerged as a critical mechanism underlying oncogenic signaling and transcriptional regulation; however, its involvement in triple‐negative breast cancer (TNBC) remains largely unknown.
Min Zhang, Chanjin Liang, Ting Chen, Xingyuan Shi, Jiqing Hao   +4 more
wiley   +1 more source

Self-organization of Plk4 regulates symmetry breaking in centriole duplication

, 2018
During centriole duplication, a single daughter centriole is formed near the mother centriole. The mechanism that determines a single duplication site is unknown.
Daiju Kitagawa, Shohei Yamamoto
core   +1 more source

PLK4 promotes centriole duplication by phosphorylating STIL to link the procentriole cartwheel to the microtubule wall

eLife, 2019
Centrioles play critical roles in organizing the assembly of the mitotic spindle and templating the formation of primary cilia. Centriole duplication occurs once per cell cycle and is regulated by Polo-like kinase 4 (PLK4).
Tyler Chistopher Moyer, Andrew Jon Holland   +1 more
doaj   +1 more source

Identification of Host Kinase Genes Required for Influenza Virus Replication and the Regulatory Role of MicroRNAs. [PDF]

PLoS ONE, 2013
Human protein kinases (HPKs) have profound effects on cellular responses. To better understand the role of HPKs and the signaling networks that influence influenza virus replication, a small interfering RNA (siRNA) screen of 720 HPKs was performed.
Abhijeet Bakre, Lauren E Andersen, Victoria Meliopoulos, Keegan Coleman, Xiuzhen Yan, Paula Brooks, Jackelyn Crabtree, S Mark Tompkins, Ralph A Tripp   +8 more
doaj   +1 more source

Genome‐wide CRISPR screen reveals an uncharacterized spliceosome regulator as new candidate immunotherapy target

iMeta, Volume 4, Issue 6, December 2025.
This study identifies the uncharacterized gene C9ORF50 as a novel regulator of immune evasion. Functioning as an intrinsically disordered protein, C9ORF50 drives liquid‐liquid phase separation to facilitate spliceosome assembly and maintain RNA splicing fidelity.
Tong Shao, Chuanyang Liu, Jingyu Kuang, Sisi Xie, Ying Qu, Yingying Li, Lulu Zhang, Fangzhou Liu, Yanhua Qi, Tao Hou, Ming Li, Sujuan Zhang, Yu Liu, Zhixiang Yuan, Jiali Liu, Yanming Hu, Jingyang Wang, Chenghu Song, Shaowei Zhang, Lingyun Zhu, Jianzhong Shao, Aifu Lin, Wenjun Mao, Guangchuan Wang, Lvyun Zhu   +24 more
wiley   +1 more source

The Concise Guide to PHARMACOLOGY 2025/26: Enzymes

British Journal of Pharmacology, Volume 182, Issue S1, Page S307-S403, December 2025.
The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander, Doriano Fabbro, Alasdair J. Gibb, Eamonn Kelly, Alistair A. Mathie, Chloe J. Peach, Emma L. Veale, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Christopher Southan, Jamie A. Davies, Stephanie Annett, Detlev Boison, Kathryn Elisa Burns, Carmen Dessauer, Jürg Gertsch, Nuala Ann Helsby, Angelo A. Izzo, Rennolds Ostrom, Ester Pagano, Andreas Papapetropoulos, Nigel J. Pyne, Susan Pyne, Tracy Robson, Roland Seifert, Johannes‐Peter Stasch, Csaba Szabo, Mario van der Stelt, Albert van der Vliet, Val Watts, Szu Shen Wong   +31 more
wiley   +1 more source

GSK461364 Inhibits NLRP3 Inflammasome by Targeting NEK7 Phosphorylation

Advanced Science, Volume 12, Issue 44, November 27, 2025.
Schematic diagram of the mechanism by which GSK461364 inhibits NLRP3 inflammasome activation. GSK461364 inhibits the phosphorylation of NEK7 likely at serine 221 and serine 260 by suppressing the activity of PLK1, thereby restraining the formation of the NLRP3 inflammasome.
Ruiheng Luo, Mingliang Ma, Dan Wang, Ling Luo, Xueming Xu, Lingmin Huang, Fupeng Wang, Guangyan Kuang, Huiqi Liu, Rui Ni, Xin Li, Qinghua Zhang, Shengfeng Wang, Kai Zhao   +13 more
wiley   +1 more source

Polo-Like Kinase 4 (PLK4) Function in Cancer Progression

, 2017
Invasion and metastasis are responsible for the majority of deaths from cancer, but the molecular mechanisms that facilitate execution of the metastatic cascade remain incompletely understood.
Kazazian, Karineh
core   +1 more source