Results 81 to 90 of about 905 (118)

Plk4 Is a Novel Substrate of Protein Phosphatase 5

, 2023
The conserved Ser/Thr protein phosphatase 5 (PP5) is involved in the regulation of key cellular processes, including DNA damage repair and cell division in eukaryotes. As a co-chaperone of Hsp90, PP5 has been shown to modulate the maturation and activity
Zoltán Lipinszki, Réthi-Nagy, Zsuzsánna, Sinka, Rita, Zsuzsánna Réthi-Nagy, Rita Sinka, Ábrahám, Edit, Péter Vilmos, Vilmos, Péter, Lipinszki, Zoltán, Edit Ábrahám   +9 more
core   +1 more source

Discovery of novel dual-targeting inhibitors against PLK1-PBD and PLK4-PB3: structure-guided pharmacophore modelling, virtual screening, molecular docking, molecular dynamics simulation, and biological evaluation

Journal of Enzyme Inhibition and Medicinal Chemistry
Aberrant expression of PLK1 and PLK4 is closely associated with tumourigenesis, and their simultaneous inhibition can effectively suppress tumour proliferation.
Changhao Zhao, Hanying Wu, Huajing Liu, Hui Dong, Miao-Miao Niu, Kun Shi, Fengzhen Wang   +6 more
doaj   +1 more source

Promotion and Suppression of Centriole Duplication Are Catalytically Coupled through PLK4 to Ensure Centriole Homeostasis

Cell Reports, 2016
PLK4 is the major kinase driving centriole duplication. Duplication occurs only once per cell cycle, forming one new (or daughter) centriole that is tightly engaged to the preexisting (or mother) centriole.
Minhee Kim, Brian P. O’Rourke, Rajesh Kumar Soni, Prasad V. Jallepalli, Ronald C. Hendrickson, Meng-Fu Bryan Tsou   +5 more
doaj   +1 more source

Tumor polo-like kinase 4 protein expression reflects lymphovascular invasion, higher Federation of Gynecology and Obstetrics stage, and shortened survival in endometrial cancer patients who undergo surgical resection

BMC Women's Health
Background Polo-like kinase 4 (PLK4) serves as a marker for tumor features and poor outcomes in cancers. This study aimed to explore the associations of tumor PLK4 protein expression with tumor characteristics and survival in endometrial cancer (EC ...
Qinyan Zhao, Minli Wang, Mingcong Chen
doaj   +1 more source

Phase separation of Polo-like kinase 4 by autoactivation and clustering drives centriole biogenesis

Nature Communications, 2019
Regulation of centriole duplication is essential for normal chromosome segregation and the maintenance of genomic stability, and Polo-like kinase 4 (Plk4) is a known regulator with unclear mechanisms.
Jung-Eun Park, Liang Zhang, Jeong Kyu Bang, Thorkell Andresson, Frank DiMaio, Kyung S. Lee   +5 more
doaj   +1 more source

Abstract 2544: Overexpression of the Polo-like kinase 4 (PLK4) contribute to tumor metastasis

, 2019
The Polo‐Like Kinase 4 (PLK4) is an important mitotic kinase that plays a critical role in centriole duplication pathway. Aberrant PLK4's level in cancer cell often results in supernumerary centrosome.
Yeung Sai Fung, Yeung, SF, Yick Pang Ching, Ching, YP   +3 more
core   +1 more source

The SCFSlimb ubiquitin ligase regulates Plk4/Sak levels to block centriole reduplication [PDF]

, 2009
Restricting centriole duplication to once per cell cycle is critical for chromosome segregation and genomic stability, but the mechanisms underlying this block to reduplication are unclear.
Rogers, Stephen L., Mark Peifer, Rusan, Nasser M., Roberts, David M., David M. Roberts, Nasser M. Rusan, Gregory C. Rogers, Rogers, Gregory C., Peifer, Mark, Stephen L. Rogers   +9 more
core   +1 more source

PLK4 SELF-PHOSPHORYLATION DRIVES THE SELECTION OF A SINGLE SITE FOR PROCENTRIOLE ASSEMBLY

, 2023
Centrioles are cylindrical-shaped organelles that recruit a surrounding pericentriolar material (PCM) to form the centrosome, a microtubule-organizing center that arranges the interphase microtubule cytoskeleton and forms the poles of the mitotic spindle
Scott, Phillip
core   +1 more source

Polo-like Kinase 4: A Molecular Culprit in Skin Cancer Pathogenesis

Cells
Skin cancer remains a significant global health challenge, with rising incidence and associated mortality in late-stage and drug-resistant cases. This underscores a continuing need for more effective novel therapeutic options that can be utilized for ...
Tanya Jaiswal, Durdana Muntaqua, Nihal Ahmad   +2 more
doaj   +1 more source

p53-Dependent and cell specific epigenetic regulation of the polo-like kinases under oxidative stress.

PLoS ONE, 2014
The polo-like kinase (PLKs) family, consisting of five known members, are key regulators of important cell cycle processes, which include mitotic entry, centrosome duplication, spindle assembly, and cytokinesis. The PLKs have been implicated in a variety
Alejandra Ward, John W Hudson
doaj   +1 more source