Results 101 to 110 of about 4,153 (193)

PLK4 as a potential target to enhance radiosensitivity in triple-negative breast cancer

Radiation Oncology
Radioresistance is one of the barriers to developing more effective therapies against the most aggressive, triple-negative, breast cancer (TNBC) subtype. In our previous studies, we showed that inhibition of Polo-like Kinase 4 (PLK4) by a novel drug, CFI-
Sierra Pellizzari, Vasudeva Bhat, Harjot Athwal, David W. Cescon, Alison L. Allan, Armen Parsyan   +5 more
doaj   +1 more source

Promotion and Suppression of Centriole Duplication Are Catalytically Coupled through PLK4 to Ensure Centriole Homeostasis

Cell Reports, 2016
PLK4 is the major kinase driving centriole duplication. Duplication occurs only once per cell cycle, forming one new (or daughter) centriole that is tightly engaged to the preexisting (or mother) centriole.
Minhee Kim, Brian P. O’Rourke, Rajesh Kumar Soni, Prasad V. Jallepalli, Ronald C. Hendrickson, Meng-Fu Bryan Tsou   +5 more
doaj   +1 more source

Phase separation of Polo-like kinase 4 by autoactivation and clustering drives centriole biogenesis

Nature Communications, 2019
Regulation of centriole duplication is essential for normal chromosome segregation and the maintenance of genomic stability, and Polo-like kinase 4 (Plk4) is a known regulator with unclear mechanisms.
Jung-Eun Park, Liang Zhang, Jeong Kyu Bang, Thorkell Andresson, Frank DiMaio, Kyung S. Lee   +5 more
doaj   +1 more source

Explorer le rôle de Plk4 in vivo

, 2016
Les centrosomes sont les principaux centres organisateurs des microtubules dans les cellules animales, impliqués dans la division, la motilité, la polarité cellulaire.
Gambarotto, Davide
core  

The Protein Phosphatase 2A regulatory subunit Twins stabilizes Plk4 to induce centriole amplification

, 2011
Centriole duplication is a tightly regulated process that must occur only once per cell cycle; otherwise, supernumerary centrioles can induce aneuploidy and tumorigenesis.
Christopher W. Brownlee, Joey E. Klebba, Gregory C. Rogers, Daniel W. Buster   +3 more
core   +1 more source

Tumor polo-like kinase 4 protein expression reflects lymphovascular invasion, higher Federation of Gynecology and Obstetrics stage, and shortened survival in endometrial cancer patients who undergo surgical resection

BMC Women's Health
Background Polo-like kinase 4 (PLK4) serves as a marker for tumor features and poor outcomes in cancers. This study aimed to explore the associations of tumor PLK4 protein expression with tumor characteristics and survival in endometrial cancer (EC ...
Qinyan Zhao, Minli Wang, Mingcong Chen
doaj   +1 more source

p53-Dependent and cell specific epigenetic regulation of the polo-like kinases under oxidative stress.

PLoS ONE, 2014
The polo-like kinase (PLKs) family, consisting of five known members, are key regulators of important cell cycle processes, which include mitotic entry, centrosome duplication, spindle assembly, and cytokinesis. The PLKs have been implicated in a variety
Alejandra Ward, John W Hudson
doaj   +1 more source

The mRNA and protein expression of PLK4 in HCC by qRT-PCR and western blot. A.

, 2013
Down-regulated expression of PLK4 mRNA was detected by qRT-PCR in 13 out of 20 HCC cases. The relative PLK4 mRNA expression was indicated by histogram (T, tumor tissue; N, the corresponding adjacent non-tumor liver tissues). B.
George Gong Chen (115651), Jia Fu (111729), Jingping Yun (111732), Lili Liu (111724), Chris Zhiyi Zhang (111721), Muyan Cai (111726)   +5 more
core   +1 more source

SmSak, the second Polo-like kinase of the helminth parasite Schistosoma mansoni: conserved and unexpected roles in meiosis.

PLoS ONE, 2012
Polo-like kinases (Plks) are a family of conserved regulators of a variety of events throughout the cell cycle, expanded from one Plk in yeast to five Plks in mammals (Plk1-5).
Thavy Long, Mathieu Vanderstraete, Katia Cailliau, Katia Cailliau, Marion Morel, Arlette Lescuyer, Nadege Gouignard, Christoph G Grevelding, Edith Browaeys, Colette Dissous   +9 more
doaj   +1 more source

Functional characterization of polo-like kinase 4 (PLK4) in hepatocellular carcinoma

, 2020
The Polo-like Kinase 4 (PLK4), a centrosomal serine-threonine (S/T) kinase, is the master regulator of centrosome duplication. Recent evidence suggested that PLK4 is frequently overexpressed in cancer and overexpression of PLK4 is linked to chemo ...
Yeung, Sai Fung, 楊世鋒
core