Results 111 to 120 of about 4,153 (193)

Plk4 Regulates Cell Motility through Arhgef1 and Rho GTPase Activation

, 2019
Cell migration is a fundamental process essential for embryogenesis, immune cell function and maintenance of homeostasis. It is driven primarily by polymerization of the actin cytoskeleton, which is regulated by a family of small Rho GTPases. Rho GTPases
Brashavitskaya, Volha
core  

The SCFSlimb ubiquitin ligase regulates Plk4/Sak levels to block centriole reduplication

, 2009
Restricting centriole duplication to once per cell cycle is critical for chromosome segregation and genomic stability, but the mechanisms underlying this block to reduplication are unclear.
Rogers, Stephen L., Mark Peifer, Rusan, Nasser M., Roberts, David M., David M. Roberts, Nasser M. Rusan, Gregory C. Rogers, Rogers, Gregory C., Peifer, Mark, Stephen L. Rogers   +9 more
core   +1 more source

Atypical function of a centrosomal module in WNT signalling drives contextual cancer cell motility

Nature Communications, 2019
Centrosomes control cell motility, polarity and migration that is thought to be mediated by their microtubule-organizing capacity. Here we demonstrate that WNT signalling drives a distinct form of non-directional cell motility that requires a key ...
Yi Luo, Miriam Barrios-Rodiles, Gagan D. Gupta, Ying Y. Zhang, Abiodun A. Ogunjimi, Mikhail Bashkurov, Johnny M. Tkach, Ainsley Q. Underhill, Liang Zhang, Mohamed Bourmoum, Jeffrey L. Wrana, Laurence Pelletier   +11 more
doaj   +1 more source

DNA replication licensing factor Cdc6 and Plk4 kinase antagonistically regulate centrosome duplication via Sas-6

, 2017
Centrosome number is tightly controlled during the cell cycle to ensure proper spindle assembly and cell division. However, the underlying mechanism that controls centrosome number remains largely unclear.
Shijiao Huang, Wangfei Chi, Jingyan Fu, Boyan Zhang, Si Li, Xiaowei Xu, Gang Wang, Qing Jiang, Chuanmao Zhang, Fan Huang   +9 more
core   +1 more source

Human Plk4 phosphorylates Cdc25C [PDF]

Cell Cycle, 2008
Sepal Bonni, Melissa L. Ganuelas, Steve Petrinac, John W. Hudson   +3 more
openaire   +1 more source

Developmental Role of plk4 in Xenopus laevis and Danio rerio: implications for Seckel Syndrome

, 2015
The polo-like kinases are a family of conserved serine/threonine kinases that play multiple roles in regulation of the cell cycle. Unlike its four other family members, the role of Plk4 in embryonic development has not been well characterized.
Crawford, Michael J, Patel, Neeraj, Rapchak, C. E., Crawford, M., Rapchak, Candace Elaine, Patel, N., Hudson, J., Hudson, John   +7 more
core   +1 more source

Plk4 trans-autophosphorylation regulates centriole number by controlling betaTrCP-mediated degradation

, 2010
Centrioles are the main constituents of the mammalian centrosome and act as basal bodies for ciliogenesis. Centrosomes organize the cytoplasmic microtubule network during interphase and the mitotic spindle during mitosis, and aberrations in centrosome ...
Erich A. Nigg, Andreas Uldschmid, Jens Westendorf, Guderian, G., Gernot Guderian, Westendorf, J., Nigg, E. A., Uldschmid, A.   +7 more
core   +1 more source

PLK4 Gene [PDF]

, 2020
openaire   +1 more source

Centrosome amplification and aneuploidy driven by the HIV-1-induced Vpr•VprBP•Plk4 complex in CD4+ T cells

Nature Communications
HIV-1 infection elevates the risk of developing various cancers, including T-cell lymphoma. Whether HIV-1-encoded proteins directly contribute to oncogenesis remains unknown.
Jung-Eun Park, Tae-Sung Kim, Yan Zeng, Melissa Mikolaj, Jong Il Ahn, Muhammad S. Alam, Christina M. Monnie, Victoria Shi, Ming Zhou, Tae-Wook Chun, Frank Maldarelli, Kedar Narayan, Jinwoo Ahn, Jonathan D. Ashwell, Klaus Strebel, Kyung S. Lee   +15 more
doaj   +1 more source

PLK4 wt Allele [PDF]

, 2020
openaire   +1 more source