Results 91 to 100 of about 4,153 (193)
Aberrant methylation of
BMC Cancer, 2011 Background Hepatocellular carcinoma (HCC), one of the most common cancers world-wide occurs twice as often in men compared to women. Predisposing conditions such as alcoholism, chronic viral hepatitis, aflatoxin B1 ingestion, and cirrhosis all contribute
Shum David +3 more
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When the Clock Is Ticking: The Role of Mitotic Duration in Cell Fate Determination
BioEssays, Volume 47, Issue 11, November 2025.Recently, several studies identified mechanisms by which cells measure mitotic duration and how this influences cell fate, leading to normal cell cycle progression or G1 arrest. In light of drug‐resistant cancer cells that continue proliferating even after mitotic errors, understanding these mechanisms opens the door for new potential therapeutic ...
Cornelia Sala, Elmar Schiebel
wiley +1 more source
Feedback loops in the Plk4–STIL–HsSAS6 network coordinate site selection for procentriole formation
Biology Open, 2019 Centrioles are duplicated once in every cell cycle, ensuring the bipolarity of the mitotic spindle. How the core components cooperate to achieve high fidelity in centriole duplication remains poorly understood. By live-cell imaging of endogenously tagged
Daisuke Takao +3 more
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Abstract 2544: Overexpression of the Polo-like kinase 4 (PLK4) contribute to tumor metastasis
, 2019 The Polo‐Like Kinase 4 (PLK4) is an important mitotic kinase that plays a critical role in centriole duplication pathway. Aberrant PLK4's level in cancer cell often results in supernumerary centrosome.
Yeung Sai Fung +3 more
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PLK4 SELF-PHOSPHORYLATION DRIVES THE SELECTION OF A SINGLE SITE FOR PROCENTRIOLE ASSEMBLY
, 2023 Centrioles are cylindrical-shaped organelles that recruit a surrounding pericentriolar material (PCM) to form the centrosome, a microtubule-organizing center that arranges the interphase microtubule cytoskeleton and forms the poles of the mitotic spindle
Scott, Phillip
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Human Cep192 and Cep152 cooperate in Plk4 recruitment and centriole duplication [PDF]
, 2013 Polo-like kinase 4 (Plk4) is a key regulator of centriole duplication, but the mechanism underlying its recruitment to mammalian centrioles is not understood.
Sonnen, Katharina F. +4 more
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Self-organization of Plk4 regulates symmetry breaking in centriole duplication
Nature Communications, 2019 During centriole duplication, Plk4 regulates formation of a single daughter centriole adjacent to the mother centriole, but the mechanism is unclear. Here, the authors show that Plk4 can undergo liquid–liquid phase separation and that the condensation ...
Shohei Yamamoto, Daiju Kitagawa
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, 2006 Plk4, formerly known as Sak, is a member of the polo-like family of kinases (Plks). In recent years, the Plks have emerged as critical regulators of cellular division.
Ko, Michael Augustine
core
Investigating the Functions of PLK4 in Epigenetic Regulation
, 2021 PLK4 is a serine/threonine kinase known to be involved in cell cycle regulation and centrosome duplication. Its protein levels are tightly regulated in order to prevent centrosome irregularities that would lead to aneuploidy and eventual oncogenesis ...
Tran, Necky
core
, 2021 The initiation of centrosome duplication is regulated by the Plk4/STIL/hsSAS-6 axis; however, the involvement of other centrosomal proteins in this process remains unclear.
송은주
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