Results 91 to 100 of about 905 (118)

Explorer le rôle de Plk4 in vivo

, 2016
Les centrosomes sont les principaux centres organisateurs des microtubules dans les cellules animales, impliqués dans la division, la motilité, la polarité cellulaire.
Gambarotto, Davide
core  

SmSak, the second Polo-like kinase of the helminth parasite Schistosoma mansoni: conserved and unexpected roles in meiosis.

PLoS ONE, 2012
Polo-like kinases (Plks) are a family of conserved regulators of a variety of events throughout the cell cycle, expanded from one Plk in yeast to five Plks in mammals (Plk1-5).
Thavy Long, Mathieu Vanderstraete, Katia Cailliau, Katia Cailliau, Marion Morel, Arlette Lescuyer, Nadege Gouignard, Christoph G Grevelding, Edith Browaeys, Colette Dissous   +9 more
doaj   +1 more source

Functional characterization of polo-like kinase 4 (PLK4) in hepatocellular carcinoma

, 2020
The Polo-like Kinase 4 (PLK4), a centrosomal serine-threonine (S/T) kinase, is the master regulator of centrosome duplication. Recent evidence suggested that PLK4 is frequently overexpressed in cancer and overexpression of PLK4 is linked to chemo ...
Yeung, Sai Fung, 楊世鋒
core  

Design, Synthesis, and Biological Activity Evaluation of Quinazoline-Based PLK4 Inhibitors

Biomedicines
Background: As a key regulator of centrosome duplication, polo-like kinase 4 (PLK4) is abnormally overexpressed in various tumors and has emerged as an important target for the development of antitumor drugs.
Wenqiang Sun, Zehui Qi, Ningyuan Hu, Nian Liu, Shuyi Mu, Haoyu Zhang, Zixuan Gao, Zirui Luo, Yin Sun, Dongmei Zhao, Maosheng Cheng   +10 more
doaj   +1 more source

The Polo kinase Plk4 functions in centriole duplication

, 2005
The human Polo-like kinase 1 (PLK1) and its functional homologues that are present in other eukaryotes have multiple, crucial roles in meiotic and mitotic cell division.
Christopher J. Wilkinson, Erich A. Nigg, Habedanck, Robert, Robert Habedanck, Stierhof, Y. D., Stierhof, York-Dieter, Wilkinson, Christopher J., Nigg, Erich A., York-Dieter Stierhof, Nigg, E. A., Wilkinson, C. J., Habedanck, R.   +11 more
core   +1 more source

The Protein Phosphatase 2A regulatory subunit Twins stabilizes Plk4 to induce centriole amplification

, 2011
Centriole duplication is a tightly regulated process that must occur only once per cell cycle; otherwise, supernumerary centrioles can induce aneuploidy and tumorigenesis.
Christopher W. Brownlee, Joey E. Klebba, Gregory C. Rogers, Daniel W. Buster   +3 more
core   +1 more source

The mRNA and protein expression of PLK4 in HCC by qRT-PCR and western blot. A.

, 2013
Down-regulated expression of PLK4 mRNA was detected by qRT-PCR in 13 out of 20 HCC cases. The relative PLK4 mRNA expression was indicated by histogram (T, tumor tissue; N, the corresponding adjacent non-tumor liver tissues). B.
George Gong Chen (115651), Jia Fu (111729), Jingping Yun (111732), Lili Liu (111724), Chris Zhiyi Zhang (111721), Muyan Cai (111726)   +5 more
core   +1 more source

DNA replication licensing factor Cdc6 and Plk4 kinase antagonistically regulate centrosome duplication via Sas-6

, 2017
Centrosome number is tightly controlled during the cell cycle to ensure proper spindle assembly and cell division. However, the underlying mechanism that controls centrosome number remains largely unclear.
Shijiao Huang, Wangfei Chi, Jingyan Fu, Boyan Zhang, Si Li, Xiaowei Xu, Gang Wang, Qing Jiang, Chuanmao Zhang, Fan Huang   +9 more
core   +1 more source

Centrosome amplification and aneuploidy driven by the HIV-1-induced Vpr•VprBP•Plk4 complex in CD4+ T cells

Nature Communications
HIV-1 infection elevates the risk of developing various cancers, including T-cell lymphoma. Whether HIV-1-encoded proteins directly contribute to oncogenesis remains unknown.
Jung-Eun Park, Tae-Sung Kim, Yan Zeng, Melissa Mikolaj, Jong Il Ahn, Muhammad S. Alam, Christina M. Monnie, Victoria Shi, Ming Zhou, Tae-Wook Chun, Frank Maldarelli, Kedar Narayan, Jinwoo Ahn, Jonathan D. Ashwell, Klaus Strebel, Kyung S. Lee   +15 more
doaj   +1 more source

Characterization of the Meiotic Niche of plk4 Heterozygous Mice [PDF]

Nearly a tenth of couples struggle with infertility and of these cases half the issues are contributed by the males. Despite continued research, about a third of the cases of male infertility are idiopathic1.
Blendea, Patrick Armand
core