Results 61 to 70 of about 4,153 (193)
The regulation of PLK4 stability by CIP2A
, 2023 The overexpression of cancerous inhibitor of protein phosphatase 2A (CIP2A), a 90kDa oncoprotein, is observed in several human cancer and correlated with cancer progression.
이수빈
core
, 2023 Centrioles duplicate when a mother centriole gives birth to a daughter that grows from its side. Polo-like-kinase 4 (PLK4), the master regulator of centriole duplication, is recruited symmetrically around the mother centriole, but it then concentrates at
Wilmott, Zac +2 more
core +1 more source
Cancer Medicine, Volume 15, Issue 3, March 2026.ABSTRACT Introduction Centrosome clustering is a cancer‐specific adaptation that allows cells with centrosome amplification to evade mitotic catastrophe and has emerged as a potential therapeutic target. We analyzed the prognostic role of several molecules related to centrosome clustering and found that Kinesin Family Member C1 (KIFC1) was strongly ...
Yoshinori Nakano +14 more
wiley +1 more source
Novel spirooxindole compounds as anticancer agents: targeting Plk4 kinase through design, synthesis, and molecular docking [PDF]
PharmaciaPlk4 plays a crucial role in controlling the duplication of centrioles and initiating the creation of centrosomes. Disruption of Plk4 leads to aneuploidy and chromosome instability, contributing to aggressive cancers, as well as microcephaly and fatal ...
Mervat S. Sammor +4 more
doaj +3 more sources
LZTS2 Negatively Regulates Centrosomal CEP135 Levels and Microtubule Nucleation
Cytoskeleton, Volume 83, Issue 3, Page 128-139, March 2026.ABSTRACT The microtubule cytoskeleton is a fundamental functional component of the cell. In vertebrate proliferating cells, centrosomes are the primary microtubule organizing center (MTOC), and their dysregulation has been linked to genomic instability and cancer.
Catarina Peneda +4 more
wiley +1 more source
A novel role for Plk4 in regulating cell spreading and motility [PDF]
Oncogene, 2014 Polo family kinase 4 (Plk4) is required for mitotic progression, and is haploinsufficient for tumor suppression and timely hepatocyte polarization in regenerating liver. At the same time, recent evidence suggests that Plk4 expression may have a role in clinical cancer progression, although the mechanisms are not clear.
C O, Rosario +8 more
openaire +2 more sources
Characterizing interacting partners and substrates of PLK4
, 2022 Polo-like kinase 4 (PLK4) is a serine/threonine kinase that is implicated in a variety of cellular processes including centrosome dynamics, cytokinesis, cell polarity, and epigenetics. PLK4 overexpression is sufficient to induce centrosome amplification,
Gosselin, Natalie Jessica
core
Zhongguo aizheng zazhi, 2021 Background and purpose: As a protein kinase that regulates the cell cycle, polo-like kinase 4 (PLK4) is involved in mitosis initiation, centrosome maturation, cytokinesis, DNA damage detection, etc., which is highly expressed in a variety of tumors ...
张进忠 +4 more
doaj
Cancer Biology & Therapy, 2023 The anti-tumor effect of polo-like kinase 4 (PLK4) inhibitor has been explored in several solid carcinomas, while its application in anaplastic thyroid cancer (ATC) remains scarce.
Wei Zhu, Bin Xie
doaj +1 more source
Journal of Cellular and Molecular Medicine, Volume 30, Issue 6, March 2026.ABSTRACT The APOE gene, which encodes Apolipoprotein E (ApoE), is the strongest genetic risk locus for Alzheimer's disease (AD). A substantial fraction of AD risk genes converges on pathways controlling lipid metabolism and immune regulation, in which microglia serve as a central integrative hub in the brain.
Dayoung Kim +6 more
wiley +1 more source