Results 61 to 70 of about 905 (118)

Lysine demethylase 4A: from chromatin to centrosomes

The FEBS Journal, Volume 293, Issue 2, Page 392-395, January 2026.
The lysine demethylase 4A (KDM4A) remodels chromatin by histone demethylation, regulating gene expression. In this issue, Chowdhury et al. report a previously undescribed localisation for KDM4A outside the nucleus, at the pericentriolar material around the centrosome.
Anushka Sharma, Ruth M. Kearney, Ciaran G. Morrison   +2 more
wiley   +1 more source

The HPV-16 E7 oncoprotein induces centriole multiplication through deregulation of Polo-like kinase 4 expression

Molecular Cancer, 2011
Background Infection with high-risk human papillomaviruses (HPVs) such as HPV-16 is intimately associated with squamous cell carcinomas (SCCs) of the anogenital tract and a subset of oropharyngeal carcinomas.
Duensing Stefan, Treat Benjamin, Korzeniewski Nina   +2 more
doaj   +1 more source

Exploring the developmental roles of plk4 [PDF]

, 2014
Plk4 is a member of the Polo-like kinase family of cell cycle regulators that has well established roles in the regulation of centrosome duplication, cytokinesis and the DNA damage response in adult cells.
Rapchak, Candace
core  

Cholesterol Reprograms Oxysterol Metabolism via the LOX1/CH25H/CYP7B1 Signaling Axis to Drive Multidrug Resistance in Colorectal Cancer

Human Mutation, Volume 2026, Issue 1, 2026.
Chemotherapeutic resistance remains a major contributor to tumor recurrence and unfavorable clinical outcomes in colorectal cancer (CRC). Although cholesterol metabolic reprogramming has been implicated in tumorigenesis, metastasis, and drug resistance across multiple malignancies, its specific role in CRC chemoresistance requires systematic ...
Haixia Cheng, Luyao Huang, Jieshen Huang, Jiasheng Feng, Kehua Huang, Mei Liu, Ji Li, Sujit Nair   +7 more
wiley   +1 more source

Combined inhibition of PLK4 and PPM1D promotes cell death in cancer cells with 17q amplification

Cancer Cell International
Background Polo-like kinase 4 (PLK4) is a key regulator of centriole duplication and contributes to mitotic spindle organization during cell division.
Miroslav Stoyanov, Cecilia Aquino-Perez, Shreyasi Mazumder, Dominika Salcakova, Silvia Petrezselyova, Libor Macurek   +5 more
doaj   +1 more source

PLK4 trans-Autoactivation Controls Centriole Biogenesis in Space [PDF]

, 2015
SummaryCentrioles are essential for cilia and centrosome assembly. In centriole-containing cells, centrioles always form juxtaposed to pre-existing ones, motivating a century-old debate on centriole biogenesis control.
Carla A.M. Lopes, Bento, Inês, Swadhin Chandra Jana, Samuel Gilberto, Mariana Lince-Faria, Inês Bento, Francisco Freixo, Carneiro, Jorge, Lopes, Carla A.M., Bettencourt-Dias, Mónica, Adán Guerrero, Freixo, Francisco, Francia, Maria, Jorge Carneiro, Duarte, Paulo, Inês Cunha-Ferreira, Mónica Bettencourt-Dias, Sihem Zitouni, Guerrero, Adán, Jana, Swadhin Chandra, Paulo Duarte, Zitouni, Sihem, Gilberto, Samuel, Maria Francia, Cunha-Ferreira, Inês, Lince-Faria, Mariana   +25 more
core   +1 more source

Analysis of Autophagy‐Related Gene Signature Associated With Clinical Prognosis and Immune Microenvironment in Colorectal Cancer

Mediators of Inflammation, Volume 2026, Issue 1, 2026.
Background Autophagy has a critical involvement in the initiation and progression of various cancers, including colorectal cancer (CRC). The feasibility of using autophagy‐related genes (ATGs) as prognostic tools for CRC patients is yet to be determined.
Dazhuang Miao, Yushui Song, Liang Zhou, Guanying Liang, Yan Wang, Wei He, Luyu Huang, Hongnan Lu, Shixiong Jiang, Yunhe Jia, Zhiwei Li, Jinxue Tong, Jasbir Arora (RSS)   +12 more
wiley   +1 more source

Polo-Like Kinase 4 (PLK4) Function in Cancer Progression

, 2017
Invasion and metastasis are responsible for the majority of deaths from cancer, but the molecular mechanisms that facilitate execution of the metastatic cascade remain incompletely understood.
Kazazian, Karineh
core   +2 more sources

Phase Separation of PHLDB2 Drives EMT and Tumor Progression in Triple‐Negative Breast Cancer

Cancer Medicine, Volume 14, Issue 23, December 2025.
ABSTRACT Background Liquid–liquid phase separation (LLPS) has emerged as a critical mechanism underlying oncogenic signaling and transcriptional regulation; however, its involvement in triple‐negative breast cancer (TNBC) remains largely unknown.
Min Zhang, Chanjin Liang, Ting Chen, Xingyuan Shi, Jiqing Hao   +4 more
wiley   +1 more source

PLK4 promotes centriole duplication by phosphorylating STIL to link the procentriole cartwheel to the microtubule wall

eLife, 2019
Centrioles play critical roles in organizing the assembly of the mitotic spindle and templating the formation of primary cilia. Centriole duplication occurs once per cell cycle and is regulated by Polo-like kinase 4 (PLK4).
Tyler Chistopher Moyer, Andrew Jon Holland   +1 more
doaj   +1 more source