Results 41 to 50 of about 905 (118)
Photochemistry and Photobiology, Volume 102, Issue 3, Page 560-576, May/June 2026.Exposure to solar ultraviolet radiation is the main etiologic driver of nonmelanoma skin cancers (NMSCs), including basal cell (BCC) and cutaneous squamous cell carcinomas (cSCC), which are the most prevalent types of cancers in the US. In this study, we demonstrate that the serine/threonine kinase Polo‐like kinase 4 (PLK4) is overexpressed in NMSCs ...
Mary A. Ndiaye +5 more
wiley +1 more source
The E3 ubiquitin ligase Mib1 regulates Plk4 and centriole biogenesis [PDF]
, 2015 Centrioles function as core components of centrosomes and as basal bodies for the formation of cilia and flagella. Thus, effective control of centriole numbers is essential for embryogenesis, tissue homeostasis, and genome stability.
Glatter, Timo +2 more
core +2 more sources
Novel spirooxindole compounds as anticancer agents: targeting Plk4 kinase through design, synthesis, and molecular docking [PDF]
PharmaciaPlk4 plays a crucial role in controlling the duplication of centrioles and initiating the creation of centrosomes. Disruption of Plk4 leads to aneuploidy and chromosome instability, contributing to aggressive cancers, as well as microcephaly and fatal ...
Mervat S. Sammor +4 more
doaj +3 more sources
NuSAP Safeguards Centriole Integrity to Mediate CEP57‐CEP152 Torus Recruitment for Proper Engagement
Advanced Science, Volume 13, Issue 19, 2 April 2026.This study reveals a novel role for the microtubule stabilizer NuSAP at centrioles. NuSAP depletion destabilizes the centriole's tubulin structure, causing premature disengagement, PCM defects, and mis‐localization of the CEP57‐CEP63‐CEP152 complex. By reinforcing centriole architecture, NuSAP enables early CEP57 loading and initiates a newly proposed ...
Shiyu Zhang +8 more
wiley +1 more source
Plk4 Regulates Cell Motility through Arhgef1 and Rho GTPase Activation [PDF]
, 2019 Cell migration is a fundamental process essential for embryogenesis, immune cell function and maintenance of homeostasis. It is driven primarily by polymerization of the actin cytoskeleton, which is regulated by a family of small Rho GTPases. Rho GTPases
Brashavitskaya, Volha
core +1 more source
Zhongguo aizheng zazhi, 2021 Background and purpose: As a protein kinase that regulates the cell cycle, polo-like kinase 4 (PLK4) is involved in mitosis initiation, centrosome maturation, cytokinesis, DNA damage detection, etc., which is highly expressed in a variety of tumors ...
张进忠 +4 more
doaj
Cancer Medicine, Volume 15, Issue 3, March 2026.ABSTRACT Introduction Centrosome clustering is a cancer‐specific adaptation that allows cells with centrosome amplification to evade mitotic catastrophe and has emerged as a potential therapeutic target. We analyzed the prognostic role of several molecules related to centrosome clustering and found that Kinesin Family Member C1 (KIFC1) was strongly ...
Yoshinori Nakano +14 more
wiley +1 more source
Cancer Cell International, 2020 Background Long noncoding RNA small nucleolar RNA host gene 16 (lncRNA SNHG16) has been revealed to be involved in the tumorigenesis of neuroblastoma.
Zhaoying Xu +4 more
doaj +1 more source
Cancer Biology & Therapy, 2023 The anti-tumor effect of polo-like kinase 4 (PLK4) inhibitor has been explored in several solid carcinomas, while its application in anaplastic thyroid cancer (ATC) remains scarce.
Wei Zhu, Bin Xie
doaj +1 more source
LZTS2 Negatively Regulates Centrosomal CEP135 Levels and Microtubule Nucleation
Cytoskeleton, Volume 83, Issue 3, Page 128-139, March 2026.ABSTRACT The microtubule cytoskeleton is a fundamental functional component of the cell. In vertebrate proliferating cells, centrosomes are the primary microtubule organizing center (MTOC), and their dysregulation has been linked to genomic instability and cancer.
Catarina Peneda +4 more
wiley +1 more source