STIL binding to Polo-box 3 of PLK4 regulates centriole duplication [PDF]
eLife, 2015 Polo-like kinases (PLK) are eukaryotic regulators of cell cycle progression, mitosis and cytokinesis; PLK4 is a master regulator of centriole duplication.
Christian Arquint +7 more
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Plk4-dependent phosphorylation of STIL is required for centriole duplication
Biology Open, 2015 Duplication of centrioles, namely the formation of a procentriole next to the parental centriole, is regulated by the polo-like kinase Plk4. Only a few other proteins, including STIL (SCL/TAL1 interrupting locus, SIL) and Sas-6, are required for the ...
Anne-Sophie Kratz +3 more
doaj +2 more sources
Bimodal Binding of STIL to Plk4 Controls Proper Centriole Copy Number
Cell Reports, 2018 Summary: The number of centrioles is tightly controlled to ensure bipolar spindle assembly, which is a prerequisite to maintain genome integrity. However, our understanding of the fundamental principle that governs the formation of a single procentriole ...
Midori Ohta +6 more
doaj +2 more sources
Polo-Like Kinase 4 (PLK4) Is Overexpressed in Central Nervous System Neuroblastoma (CNS-NB)
Bioengineering, 2018 Neuroblastoma (NB) is the most common extracranial solid tumor in pediatrics, with rare occurrences of primary and metastatic tumors in the central nervous system (CNS).
Anders W. Bailey +7 more
doaj +2 more sources
Use of the Polo-like kinase 4 (PLK4) inhibitor centrinone to investigate intracellular signalling networks using SILAC-based phosphoproteomics [PDF]
, 2020 Polo-like kinase 4 (PLK4) is the master regulator of centriole duplication in metazoan organisms. Catalytic activity and protein turnover of PLK4 are tightly coupled in human cells, since changes in PLK4 concentration and catalysis have profound effects ...
Jones, Andrew R +9 more
core +1 more source
Characterizing interacting partners and substrates of PLK4 [PDF]
, 2022 Polo-like kinase 4 (PLK4) is a serine/threonine kinase that is implicated in a variety of cellular processes including centrosome dynamics, cytokinesis, cell polarity, and epigenetics. PLK4 overexpression is sufficient to induce centrosome amplification,
Gosselin, Natalie Jessica
core +1 more source
On the regulation of centriole duplication in human cells : exploring the interactions of polo-like kinase 4 with the centrosomal proteins Cep192 and STIL [PDF]
, 2015 Centrioles duplicate once in each cell cycle to give rise to two centrosomes that form the spindle poles during mitosis. Aberrant centriole duplication can result in the formation of supernumerary centrosomes, leading to incorrect spindle assembly and ...
Gabryjonczyk, Anna-Maria
core +1 more source
Control of centriole numbers by Plk4 autophosphorylation and βTrCP-mediated degradation [PDF]
, 2010 Proper centrosome numbers are imperative for faithful cell division, as aberrant centrosome numbers can lead to chromosomal instability, a hallmark of cancer development (Nigg 2002; Ganem et al., 2009).
Guderian, Gernot
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A self-assembled cylindrical platform for Plk4-induced centriole biogenesis [PDF]
Open Biology, 2020 The centrosome, a unique membraneless multiprotein organelle, plays a pivotal role in various cellular processes that are critical for promoting cell proliferation.
Kyung S. Lee +4 more
doaj +1 more source
Investigation of human centrosomes - with a special focus on the function of Cep152 and Cep192 in centriole duplication [PDF]
, 2012 Centrioles are symmetrical, barrel-shaped, microtubule-based structures, that serve as building platforms for the formation of centrosomes and cilia. In dividing cells, they recruit a matrix of proteins called pericentriolar material (PCM) to form the ...
Sonnen, Katharina Friederike
core +1 more source