Results 11 to 20 of about 4,153 (193)
Plk4-dependent phosphorylation of STIL is required for centriole duplication [PDF]
Biology Open, 2015 Duplication of centrioles, namely the formation of a procentriole next to the parental centriole, is regulated by the polo-like kinase Plk4. Only a few other proteins, including STIL (SCL/TAL1 interrupting locus, SIL) and Sas-6, are required for the ...
Anne-Sophie Kratz +3 more
doaj +4 more sources
STIL binding to Polo-box 3 of PLK4 regulates centriole duplication [PDF]
eLife, 2015 Polo-like kinases (PLK) are eukaryotic regulators of cell cycle progression, mitosis and cytokinesis; PLK4 is a master regulator of centriole duplication.
Christian Arquint +7 more
doaj +2 more sources
Cep152 interacts with Plk4 and is required for centriole duplication [PDF]
Journal of Cell Biology, 2010 Centrioles are microtubule-based structures that organize the centrosome and nucleate cilia. Centrioles duplicate once per cell cycle, and duplication requires Plk4, a member of the Polo-like kinase family; however, the mechanism linking Plk4 activity and centriole formation is unknown. In this study, we show in human and frog cells that Plk4 interacts
Hatch, Emily M +4 more
openaire +6 more sources
Plk4 Is a Novel Substrate of Protein Phosphatase 5 [PDF]
International Journal of Molecular Sciences, 2023 The conserved Ser/Thr protein phosphatase 5 (PP5) is involved in the regulation of key cellular processes, including DNA damage repair and cell division in eukaryotes. As a co-chaperone of Hsp90, PP5 has been shown to modulate the maturation and activity of numerous oncogenic kinases.
Edit Ábrahám +4 more
core +5 more sources
TRIM37 controls cancer-specific vulnerability to PLK4 inhibition [PDF]
Nature, 2020 Centrosomes catalyse the formation of microtubules needed to assemble the mitotic spindle apparatus1. Centrosomes themselves duplicate once per cell cycle, in a process that is controlled by the serine/threonine protein kinase PLK4 (refs. 2,3). When PLK4 is chemically inhibited, cell division proceeds without centrosome duplication, generating ...
Franz Meitinger +10 more
openaire +5 more sources
Autoamplification and Competition Drive Symmetry Breaking: Initiation of Centriole Duplication by the PLK4-STIL Network [PDF]
iScience, 2018 Summary: Centrioles, the cores of centrosomes and cilia, duplicate every cell cycle to ensure their faithful inheritance. How only a single procentriole is produced on each mother centriole remains enigmatic.
Marcin Leda +2 more
doaj +2 more sources
Regulation of Autophosphorylation Controls PLK4 Self-Destruction and Centriole Number [PDF]
Current Biology, 2013 Polo-like kinase 4 (PLK4) is a major player in centriole biogenesis: in its absence centrioles fail to form, while in excess leads to centriole amplification. The SCF-Slimb/βTrCP-E3 ubiquitin ligase controls PLK4 levels through recognition of a conserved phosphodegron.
Cunha-Ferreira I +13 more
openaire +4 more sources
Bimodal Binding of STIL to Plk4 Controls Proper Centriole Copy Number
Cell Reports, 2018 Summary: The number of centrioles is tightly controlled to ensure bipolar spindle assembly, which is a prerequisite to maintain genome integrity. However, our understanding of the fundamental principle that governs the formation of a single procentriole ...
Midori Ohta +6 more
doaj +2 more sources
PLK4 phosphorylation of CP110 is required for efficient centriole assembly [PDF]
Cell Cycle, 2017 Centrioles are assembled during S phase and segregated into 2 daughter cells at the end of mitosis. The initiation of centriole assembly is regulated by polo-like kinase 4 (PLK4), the major serine/threonine kinase in centrioles. Despite its importance in centriole duplication, only a few substrates have been identified, and the detailed mechanism of ...
Miseon, Lee +4 more
openaire +4 more sources
PLK4 trans-Autoactivation Controls Centriole Biogenesis in Space [PDF]
Developmental Cell, 2015 Centrioles are essential for cilia and centrosome assembly. In centriole-containing cells, centrioles always form juxtaposed to pre-existing ones, motivating a century-old debate on centriole biogenesis control. Here, we show that trans-autoactivation of Polo-like kinase 4 (PLK4), the trigger of centriole biogenesis, is a critical event in the spatial ...
Carla A.M. Lopes +12 more
openaire +5 more sources