Results 31 to 40 of about 3,996 (179)
Centrin-2 Is Required for Centriole Duplication in Mammalian Cells [PDF]
Current Biology, 2002 Centrosomes are the favored microtubule-organizing framework of eukaryotic cells. Centrosomes contain a pair of centrioles that normally duplicate once during the cell cycle to give rise to two mitotic spindle poles, each containing one old and one new centriole. However, aside from their role as an anchor point for pericentriolar material and as basal
Salisbury, Jeffrey L +3 more
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Cep57 and Cep57L1 maintain centriole engagement in interphase to ensure centriole duplication cycle. [PDF]
J Cell Biol, 2021 Centrioles duplicate in interphase only once per cell cycle. Newly formed centrioles remain associated with their mother centrioles. The two centrioles disengage at the end of mitosis, which licenses centriole duplication in the next cell cycle. Therefore, timely centriole disengagement is critical for the proper centriole duplication cycle.
Ito KK +6 more
europepmc +3 more sources
Ubiquitin signaling in the control of centriole duplication [PDF]
The FEBS Journal, 2021 The centrosome plays an essential role in maintaining genetic stability, ciliogenesis and cell polarisation. The core of the centrosome is made up of two centrioles that duplicate precisely once during every cell cycle to generate two centrosomes that are required for bipolar spindle assembly and chromosome segregation.
Binshad Badarudeen +3 more
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Once and only once: mechanisms of centriole duplication and their deregulation in disease [PDF]
Nature Reviews Molecular Cell Biology, 2018 Erich A Nigg +2 more
exaly +2 more sources
A Structural Study of Conserved Centriole Duplication Machinery
, 2014 Centrioles are microtubule-based cylindrical structures that act within organelles responsible for nucleating polarized microtubule networks. Centrioles have an inherent nine-fold radial symmetry with species-dependent dimensions. Despite the fact that centrioles have been described by biologists for over a century, the process by which cells license ...
Slevin, Lauren K.
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Open Biology, 2022 Centrosomes are important organizers of microtubules within animal cells. They comprise a pair of centrioles surrounded by the pericentriolar material, which nucleates and organizes the microtubules.
Neil H. J. Cunningham +2 more
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Cell Cycle, 2010 In interphase and mitosis, centrosomes play a major role in the spatial organization of the microtubule network. Alterations in centrosome number and structure are associated with genomic instability and occur in many cancers. Centrosome duplication is controlled by centriole replication.
Andrew J, Holland +2 more
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PLoS Genetics, 2022 Centrioles are submicron-scale, barrel-shaped organelles typically found in pairs, and play important roles in ciliogenesis and bipolar spindle assembly.
Jyoti Iyer +10 more
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Mode of centriole duplication and distribution. [PDF]
The Journal of cell biology, 1990 Centriole stability and distribution during the mammalian cell cycle was studied by microinjecting biotinylated tubulin into early G1 cells and analyzing the pattern of incorporation into centrioles. Cells were extracted and cold treated to depolymerize labile microtubules, allowing the fluorescent microscopic visualization of the stable centrioles ...
R S, Kochanski, G G, Borisy
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The RAC1 activator Tiam1 regulates centriole duplication through controlling PLK4 levels.
J Cell Sci, 2021 Centriole duplication is tightly controlled to maintain correct centriole number through the cell cycle. Key to this is the regulated degradation of PLK4, the master regulator of centriole duplication.
Porter AP +5 more
europepmc +2 more sources