Results 11 to 20 of about 3,996 (179)
Promotion and Suppression of Centriole Duplication Are Catalytically Coupled through PLK4 to Ensure Centriole Homeostasis [PDF]
Cell Reports, 2016 PLK4 is the major kinase driving centriole duplication. Duplication occurs only once per cell cycle, forming one new (or daughter) centriole that is tightly engaged to the preexisting (or mother) centriole.
Minhee Kim +5 more
doaj +6 more sources
Cep63 and cep152 cooperate to ensure centriole duplication. [PDF]
PLoS ONE, 2013 Centrosomes consist of two centrioles embedded in pericentriolar material and function as the main microtubule organising centres in dividing animal cells.
Nicola J Brown +4 more
doaj +9 more sources
Plk4-dependent phosphorylation of STIL is required for centriole duplication [PDF]
Biology Open, 2015 Duplication of centrioles, namely the formation of a procentriole next to the parental centriole, is regulated by the polo-like kinase Plk4. Only a few other proteins, including STIL (SCL/TAL1 interrupting locus, SIL) and Sas-6, are required for the ...
Anne-Sophie Kratz +3 more
doaj +6 more sources
The centriole duplication cycle [PDF]
Philosophical Transactions of the Royal Society B: Biological Sciences, 2014 Centrosomes are the main microtubule-organizing centre of animal cells and are important for many critical cellular and developmental processes from cell polarization to cell division. At the core of the centrosome are centrioles, which recruit pericentriolar material to form the centrosome and act as basal bodies to nucleate formation of cilia and ...
Tim Stearns
exaly +5 more sources
Centriole Duplication: Centrin in on Answers? [PDF]
Current Biology, 2002 Many aspects of centriole biology remain mysterious. A new study has shed light on the role of the centriolar protein centrin-2: reducing levels of centrin-2 in HeLa cells has been found to block centriole duplication, eventually leading to cell death.
Rice, Luke M, Agard, David A
openaire +3 more sources
CDK11(p58) is required for centriole duplication and Plk4 recruitment to mitotic centrosomes. [PDF]
PLoS ONE, 2011 BACKGROUND: CDK11(p58) is a mitotic protein kinase, which has been shown to be required for different mitotic events such as centrosome maturation, chromatid cohesion and cytokinesis.
Nathalie Franck +5 more
doaj +2 more sources
Drosophila Ana2 is a conserved centriole duplication factor [PDF]
Journal of Cell Biology, 2010 In Caenorhabditis elegans, five proteins are required for centriole duplication: SPD-2, ZYG-1, SAS-5, SAS-6, and SAS-4. Functional orthologues of all but SAS-5 have been found in other species. In Drosophila melanogaster and humans, Sak/Plk4, DSas-6/hSas-6, and DSas-4/CPAP—orthologues of ZYG-1, SAS-6, and SAS-4, respectively—are required for centriole ...
Stevens, Naomi +4 more
openaire +3 more sources
Cep152 interacts with Plk4 and is required for centriole duplication [PDF]
Journal of Cell Biology, 2010 Centrioles are microtubule-based structures that organize the centrosome and nucleate cilia. Centrioles duplicate once per cell cycle, and duplication requires Plk4, a member of the Polo-like kinase family; however, the mechanism linking Plk4 activity and centriole formation is unknown. In this study, we show in human and frog cells that Plk4 interacts
Hatch, Emily M +4 more
openaire +6 more sources
Alstrom syndrome gene is a stem-cell-specific regulator of centriole duplication in the Drosophila testis [PDF]
eLife, 2020 Asymmetrically dividing stem cells often show asymmetric behavior of the mother versus daughter centrosomes, whereby the self-renewing stem cell selectively inherits the mother or daughter centrosome. Although the asymmetric centrosome behavior is widely
Cuie Chen, Yukiko M Yamashita
doaj +2 more sources
A Short CEP135 Splice Isoform Controls Centriole Duplication. [PDF]
Curr Biol, 2015 Centriole duplication is coordinated such that a single round of duplication occurs during each cell cycle. Disruption of this synchrony causes defects including supernumerary centrosomes in cancer and perturbed ciliary signaling [1-5]. To preserve the normal number of centrioles, the level, localization, and post-translational modification of ...
Dahl KD +7 more
europepmc +5 more sources