Results 11 to 20 of about 83,983 (175)
Cep63 and cep152 cooperate to ensure centriole duplication. [PDF]
PLoS ONE, 2013 Centrosomes consist of two centrioles embedded in pericentriolar material and function as the main microtubule organising centres in dividing animal cells.
Nicola J Brown +4 more
doaj +8 more sources
Promotion and Suppression of Centriole Duplication Are Catalytically Coupled through PLK4 to Ensure Centriole Homeostasis [PDF]
Cell Reports, 2016 PLK4 is the major kinase driving centriole duplication. Duplication occurs only once per cell cycle, forming one new (or daughter) centriole that is tightly engaged to the preexisting (or mother) centriole.
Minhee Kim +5 more
doaj +5 more sources
The centriole duplication cycle [PDF]
Philosophical Transactions of the Royal Society B: Biological Sciences, 2014 Centrosomes are the main microtubule-organizing centre of animal cells and are important for many critical cellular and developmental processes from cell polarization to cell division. At the core of the centrosome are centrioles, which recruit pericentriolar material to form the centrosome and act as basal bodies to nucleate formation of cilia and ...
Elif Fırat-Karalar, Tim Stearns
exaly +5 more sources
Centriole Duplication: Centrin in on Answers? [PDF]
Current Biology, 2002 Many aspects of centriole biology remain mysterious. A new study has shed light on the role of the centriolar protein centrin-2: reducing levels of centrin-2 in HeLa cells has been found to block centriole duplication, eventually leading to cell death.
Rice, Luke M, Agard, David A
openaire +4 more sources
Alstrom syndrome gene is a stem-cell-specific regulator of centriole duplication in the Drosophila testis [PDF]
eLife, 2020 Asymmetrically dividing stem cells often show asymmetric behavior of the mother versus daughter centrosomes, whereby the self-renewing stem cell selectively inherits the mother or daughter centrosome. Although the asymmetric centrosome behavior is widely
Cuie Chen, Yukiko M Yamashita
doaj +2 more sources
Drosophila Ana2 is a conserved centriole duplication factor [PDF]
Journal of Cell Biology, 2010 In Caenorhabditis elegans, five proteins are required for centriole duplication: SPD-2, ZYG-1, SAS-5, SAS-6, and SAS-4. Functional orthologues of all but SAS-5 have been found in other species. In Drosophila melanogaster and humans, Sak/Plk4, DSas-6/hSas-6, and DSas-4/CPAP—orthologues of ZYG-1, SAS-6, and SAS-4, respectively—are required for centriole ...
Stevens, Naomi +4 more
openaire +4 more sources
Centriole Duplication: When PLK4 Meets Ana2/STIL [PDF]
Current Biology, 2014 Polo-like kinase 4 is known to drive centriole duplication, but the relevant substrate remains elusive. A new study shows that PLK4 phosphorylates a key centriolar component, Ana2/STIL, to initiate centriole assembly.
Kim, Minhee +2 more
openaire +4 more sources
Cell Reports, 2014 Vertebrate centrioles lose their geometric scaffold, the cartwheel, during mitosis, concurrently with gaining the ability to recruit the pericentriolar material (PCM) and thereby function as the centrosome.
Denisse Izquierdo +3 more
doaj +3 more sources
A Short CEP135 Splice Isoform Controls Centriole Duplication. [PDF]
Curr Biol, 2015 Centriole duplication is coordinated such that a single round of duplication occurs during each cell cycle. Disruption of this synchrony causes defects including supernumerary centrosomes in cancer and perturbed ciliary signaling [1-5]. To preserve the normal number of centrioles, the level, localization, and post-translational modification of ...
Dahl KD +7 more
europepmc +6 more sources
Drosophila Spd-2 Recruits PCM to the Sperm Centriole, but Is Dispensable for Centriole Duplication [PDF]
Current Biology, 2007 In C. elegans, genome-wide screens have identified just five essential centriole-duplication factors: SPD-2, ZYG-1, SAS-5, SAS-6, and SAS-4 [1-8]. These proteins are widely believed to comprise a conserved core duplication module [3, 9-14]. In worm embryos, SPD-2 is the most upstream component of this module, and it is also essential for pericentriolar
Dix, C, Raff, J
openaire +4 more sources