Results 21 to 30 of about 83,983 (175)
PLK4 promotes centriole duplication by phosphorylating STIL to link the procentriole cartwheel to the microtubule wall [PDF]
eLife, 2019 Centrioles play critical roles in organizing the assembly of the mitotic spindle and templating the formation of primary cilia. Centriole duplication occurs once per cell cycle and is regulated by Polo-like kinase 4 (PLK4).
Tyler Chistopher Moyer +1 more
doaj +2 more sources
A Quarter Century of EHD Protein Research: From Endosomal Recycling to Ciliopathies. [PDF]
TrafficHuman EHD protein subcellular localization. ABSTRACT Eps15 homology domain‐containing proteins comprise a conserved family of membrane‐remodeling ATPases that regulate endocytic trafficking, membrane fission, receptor recycling, primary ciliogenesis and membrane dynamics across eukaryotes. Since the initial identification of EHD1 and its Caenorhabditis
Frisby D +3 more
europepmc +2 more sources
McIdas localizes to centrioles and controls centriole numbers through PLK4-dependent phosphorylation [PDF]
EMBO ReportsThe centriole duplication cycle must be tightly controlled and coordinated with the chromosome cycle. Aberrations in centriole biogenesis can cause developmental disorders, ciliopathies and cancer, yet the molecular determinants controlling centriole ...
Marina Arbi +16 more
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Plk4-dependent phosphorylation of STIL is required for centriole duplication [PDF]
Biology Open, 2015 Duplication of centrioles, namely the formation of a procentriole next to the parental centriole, is regulated by the polo-like kinase Plk4. Only a few other proteins, including STIL (SCL/TAL1 interrupting locus, SIL) and Sas-6, are required for the ...
Anne-Sophie Kratz +3 more
doaj +3 more sources
Cep57 and Cep57L1 maintain centriole engagement in interphase to ensure centriole duplication cycle. [PDF]
J Cell Biol, 2021 Centrioles duplicate in interphase only once per cell cycle. Newly formed centrioles remain associated with their mother centrioles. The two centrioles disengage at the end of mitosis, which licenses centriole duplication in the next cell cycle. Therefore, timely centriole disengagement is critical for the proper centriole duplication cycle.
Ito KK +6 more
europepmc +3 more sources
Current biology : CB, 2001 Centriole duplication is a key step in the cell cycle whose mechanism is completely unknown. Why new centrioles always form next to preexisting ones is a fundamental question. The simplest model is that preexisting centrioles nucleate the assembly of new centrioles, and that although centrioles can in some cases form de novo without this nucleation ...
Marshall, Wallace F +2 more
openaire +3 more sources
Ubiquitin signaling in the control of centriole duplication [PDF]
The FEBS Journal, 2021 The centrosome plays an essential role in maintaining genetic stability, ciliogenesis and cell polarisation. The core of the centrosome is made up of two centrioles that duplicate precisely once during every cell cycle to generate two centrosomes that are required for bipolar spindle assembly and chromosome segregation.
Binshad Badarudeen +3 more
openaire +2 more sources
Once and only once: mechanisms of centriole duplication and their deregulation in disease [PDF]
Nature Reviews Molecular Cell Biology, 2018 Andrew J Holland, Erich Nigg
exaly +2 more sources
CDK11(p58) is required for centriole duplication and Plk4 recruitment to mitotic centrosomes. [PDF]
PLoS ONE, 2011 BACKGROUND: CDK11(p58) is a mitotic protein kinase, which has been shown to be required for different mitotic events such as centrosome maturation, chromatid cohesion and cytokinesis.
Nathalie Franck +5 more
doaj +1 more source
Open Biology, 2022 Centrosomes are important organizers of microtubules within animal cells. They comprise a pair of centrioles surrounded by the pericentriolar material, which nucleates and organizes the microtubules.
Neil H. J. Cunningham +2 more
doaj +1 more source