Results 21 to 30 of about 3,996 (179)

The E2F-DP1 Transcription Factor Complex Regulates Centriole Duplication in Caenorhabditis elegans

G3: Genes, Genomes, Genetics, 2016
Centrioles play critical roles in the organization of microtubule-based structures, from the mitotic spindle to cilia and flagella. In order to properly execute their various functions, centrioles are subjected to stringent copy number control.
Jacqueline G. Miller, Yan Liu, Christopher W. Williams, Harold E. Smith, Kevin F. O’Connell   +4 more
doaj   +2 more sources

Centriole Duplication: When PLK4 Meets Ana2/STIL [PDF]

Current Biology, 2014
Polo-like kinase 4 is known to drive centriole duplication, but the relevant substrate remains elusive. A new study shows that PLK4 phosphorylates a key centriolar component, Ana2/STIL, to initiate centriole assembly.
Kim, Minhee, Fong, Chii Shyang, Bryan Tsou, Meng-Fu   +2 more
openaire   +3 more sources

A Quarter Century of EHD Protein Research: From Endosomal Recycling to Ciliopathies. [PDF]

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Human EHD protein subcellular localization. ABSTRACT Eps15 homology domain‐containing proteins comprise a conserved family of membrane‐remodeling ATPases that regulate endocytic trafficking, membrane fission, receptor recycling, primary ciliogenesis and membrane dynamics across eukaryotes. Since the initial identification of EHD1 and its Caenorhabditis
Frisby D, Misri G, Naslavsky N, Caplan S.   +3 more
europepmc   +2 more sources

McIdas localizes to centrioles and controls centriole numbers through PLK4-dependent phosphorylation [PDF]

EMBO Reports
The centriole duplication cycle must be tightly controlled and coordinated with the chromosome cycle. Aberrations in centriole biogenesis can cause developmental disorders, ciliopathies and cancer, yet the molecular determinants controlling centriole ...
Marina Arbi, Margarita Skamnelou, Lydia Koufoudaki, Vasiliki Bakali, Spyridoula Bournaka, Sihem Zitouni, Stavroula Tsaridou, Ozge Karayel, Catherine G Vasilopoulou, Aikaterini C Tsika, Nikolaos N Giakoumakis, Ourania Preza, Georgios A Spyroulias, Matthias Mann, Mónica Bettencourt-Dias, Stavros Taraviras, Zoi Lygerou   +16 more
doaj   +2 more sources

Stabilization of Cartwheel-less Centrioles for Duplication Requires CEP295-Mediated Centriole-to-Centrosome Conversion

Cell Reports, 2014
Vertebrate centrioles lose their geometric scaffold, the cartwheel, during mitosis, concurrently with gaining the ability to recruit the pericentriolar material (PCM) and thereby function as the centrosome.
Denisse Izquierdo, Won-Jing Wang, Kunihiro Uryu, Meng-Fu Bryan Tsou   +3 more
doaj   +3 more sources

Drosophila Spd-2 Recruits PCM to the Sperm Centriole, but Is Dispensable for Centriole Duplication

Current Biology, 2007
In C. elegans, genome-wide screens have identified just five essential centriole-duplication factors: SPD-2, ZYG-1, SAS-5, SAS-6, and SAS-4 [1-8]. These proteins are widely believed to comprise a conserved core duplication module [3, 9-14]. In worm embryos, SPD-2 is the most upstream component of this module, and it is also essential for pericentriolar
Dix, C, Raff, J
openaire   +4 more sources

PLK4 promotes centriole duplication by phosphorylating STIL to link the procentriole cartwheel to the microtubule wall [PDF]

eLife, 2019
Centrioles play critical roles in organizing the assembly of the mitotic spindle and templating the formation of primary cilia. Centriole duplication occurs once per cell cycle and is regulated by Polo-like kinase 4 (PLK4).
Tyler Chistopher Moyer, Andrew Jon Holland   +1 more
doaj   +2 more sources

Centriolar satellites assemble centrosomal microcephaly proteins to recruit CDK2 and promote centriole duplication

eLife, 2015
Primary microcephaly (MCPH) associated proteins CDK5RAP2, CEP152, WDR62 and CEP63 colocalize at the centrosome. We found that they interact to promote centriole duplication and form a hierarchy in which each is required to localize another to the ...
Andrew Kodani, Timothy W Yu, Jeffrey R Johnson, Divya Jayaraman, Tasha L Johnson, Lihadh Al-Gazali, Lāszló Sztriha, Jennifer N Partlow, Hanjun Kim, Alexis L Krup, Alexander Dammermann, Nevan J Krogan, Christopher A Walsh, Jeremy F Reiter   +13 more
doaj   +2 more sources

NuSAP Safeguards Centriole Integrity to Mediate CEP57-CEP152 Torus Recruitment for Proper Engagement. [PDF]

Adv Sci (Weinh)
This study reveals a novel role for the microtubule stabilizer NuSAP at centrioles. NuSAP depletion destabilizes the centriole's tubulin structure, causing premature disengagement, PCM defects, and mis‐localization of the CEP57‐CEP63‐CEP152 complex. By reinforcing centriole architecture, NuSAP enables early CEP57 loading and initiates a newly proposed ...
Zhang S, Jiang Z, Yang Q, Zheng H, Wang M, Zhu C, Deng LW, Crasta KC, Liou YC.   +8 more
europepmc   +2 more sources

Kinetics and regulation of de novo centriole assembly. Implications for the mechanism of centriole duplication.

Current biology : CB, 2001
Centriole duplication is a key step in the cell cycle whose mechanism is completely unknown. Why new centrioles always form next to preexisting ones is a fundamental question. The simplest model is that preexisting centrioles nucleate the assembly of new centrioles, and that although centrioles can in some cases form de novo without this nucleation ...
Marshall, Wallace F, Vucica, Yvonne, Rosenbaum, Joel L   +2 more
core   +4 more sources