Results 31 to 40 of about 13,342 (208)
Pericentrin-mediated SAS-6 recruitment promotes centriole assembly
eLife, 2019 The centrosome is composed of two centrioles surrounded by a microtubule-nucleating pericentriolar material (PCM). Although centrioles are known to regulate PCM assembly, it is less known whether and how the PCM contributes to centriole assembly. Here we
Daisuke Ito +8 more
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Atypical centrioles are present in Tribolium sperm [PDF]
Open Biology, 2017 Typical centrioles are made of microtubules organized in ninefold symmetry. Most animal somatic cells have two centrioles for normal cell division and function.
E. L. Fishman +6 more
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Investigating the cellular and molecular mechanisms involved in establishing and maintaining centrosome asymmetry in Drosophila neuroblasts [PDF]
, 2015 Centrosome asymmetry has been implicated in stem cell fate maintenance in both flies and vertebrates. Drosophila neuroblasts, the neural precursors of the fly’s central nervous system, contain molecularly and physically asymmetric centrosomes.
Nair, Anjana Ramdas
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eLife, 2020 Directional sensitivity of hair cells (HCs) is conferred by the aymmetric apical hair bundle, comprised of a kinocilium and stereocilia staircase. The mother centriole (MC) forms the base of the kinocilium and the stereocilia develop adjacent to it ...
Yosuke Tona, Doris K Wu
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Frontiers in Molecular Biosciences, 2023 Primary cilia from the brain microvascular endothelial cells (ECs) are specialized cell-surface organelles involved in mediating sensory perception, cell signaling, and vascular stability.
Karthikeyan Thirugnanam +6 more
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Current Opinion in Cell Biology, 2009 Centrioles are cylindrical structures found at the core of the mitotic spindle pole, which also act as basal bodies to nucleate the formation of cilia. Centrioles have a complex, ninefold symmetric structure, and reproduce by an intriguing duplication process. The complexity and apparent self-reproduction of centrioles raises the question of how such a
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Overview of the centriole architecture
Current Opinion in Structural Biology, 2021 The centriole is a magnificent molecular assembly of several giga-daltons, one of the largest of the eukaryotic cell, and whose atomic structure remains unsolved to date. However, numerous electron microscopy, cryo-tomography, and super-resolution studies now make it possible to establish a global architectural view of it with its different sub-regions.
LeGuennec, Maeva +4 more
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WDR90 is a centriolar microtubule wall protein important for centriole architecture integrity [PDF]
, 2020 Centrioles are characterized by a nine-fold arrangement of microtubule triplets held together by an inner protein scaffold. These structurally robust organelles experience strenuous cellular processes such as cell division or ciliary beating while ...
Borgers, Susanne +28 more
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C-Nap1, a novel centrosomal coiled-coil protein and candidate substrate of the cell cycle-regulated protein kinase Nek2 [PDF]
, 1998 Nek2 (for NIMA-related kinase 2) is a mammalian cell cycle-regulated kinase structurally related to the mitotic regulator NIMA of Aspergillus nidulans.
Fry, A. M. +17 more
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The E2F-DP1 Transcription Factor Complex Regulates Centriole Duplication in Caenorhabditis elegans
G3: Genes, Genomes, Genetics, 2016 Centrioles play critical roles in the organization of microtubule-based structures, from the mitotic spindle to cilia and flagella. In order to properly execute their various functions, centrioles are subjected to stringent copy number control.
Jacqueline G. Miller +4 more
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