Results 31 to 40 of about 10,058 (131)
Identification of novel genes regulating the development of the palate
Developmental Dynamics, EarlyView.Abstract Background The International Mouse Phenotyping Consortium (IMPC) has generated thousands of knockout mouse lines, many of which exhibit embryonic or perinatal lethality. Using micro‐computed tomography (micro‐CT), the IMPC has created and publicly released three‐dimensional image data sets of embryos from these lethal and subviable lines.
Ashwin Bhaskar, Sophie Astrof
wiley +1 more source
eLife, 2019 Centrioles play critical roles in organizing the assembly of the mitotic spindle and templating the formation of primary cilia. Centriole duplication occurs once per cell cycle and is regulated by Polo-like kinase 4 (PLK4).
Tyler Chistopher Moyer +1 more
doaj +1 more source
The use of deidentified organ donor testes for research
Andrology, EarlyView.Abstract Our knowledge of testis development and function mainly comes from research using mammalian model organisms, primarily the mouse. However, there are integral differences between men and other mammalian species regarding cellular composition and expression profiles during fetal and post‐natal testis development and in the mature testis ...
Marina V. Pryzhkova +4 more
wiley +1 more source
The Role of Sperm Centrioles in Human Reproduction – The Known and the Unknown
Frontiers in Cell and Developmental Biology, 2019 Each human spermatozoon contains two remodeled centrioles that it contributes to the zygote. There, the centrioles reconstitute a centrosome that assembles the sperm aster and participate in pronuclei migration and cleavage. Thus, centriole abnormalities
Tomer Avidor-Reiss +6 more
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Andrology, EarlyView.ABSTRACT Background More than 1000 genes have been identified as predominantly expressed in the human testis. Advances in gene editing technologies have enabled the rapid and efficient generation of genetically engineered mice. This approach facilitates the screening of genes essential for spermatogenesis by analyzing knockout mouse models.
Yumiao Qiu +2 more
wiley +1 more source
Nature CommunicationsCentriole integrity, vital for cilia formation and chromosome segregation, is crucial for human health. The inner scaffold within the centriole lumen composed of the proteins POC1B, POC5 and FAM161A is key to this integrity.
Cornelia Sala +7 more
doaj +1 more source
Acta Zoologica, EarlyView.ABSTRACT Marine gastrotrichs inhabit sediments with limited available light, yet evidence suggests that photoreceptor organs are present throughout the phylum Gastrotricha. Here, we confirm this proposition with ultrastructural descriptions of photoreceptive organs in two species of Xenotrichulidae (Order Chaetonotida) that lack pigmented ocelli ...
Thiago Quintão Araújo, Rick Hochberg
wiley +1 more source
Self-organization of Plk4 regulates symmetry breaking in centriole duplication
Nature Communications, 2019 During centriole duplication, Plk4 regulates formation of a single daughter centriole adjacent to the mother centriole, but the mechanism is unclear. Here, the authors show that Plk4 can undergo liquid–liquid phase separation and that the condensation ...
Shohei Yamamoto, Daiju Kitagawa
doaj +1 more source
eLife, 2017 The centriole/basal body is a eukaryotic organelle that plays essential roles in cell division and signaling. Among five known core centriole proteins, SPD-2/Cep192 is the first recruited to the site of daughter centriole formation and regulates the ...
Kenji Sugioka +8 more
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Cep63 and cep152 cooperate to ensure centriole duplication. [PDF]
PLoS ONE, 2013 Centrosomes consist of two centrioles embedded in pericentriolar material and function as the main microtubule organising centres in dividing animal cells.
Nicola J Brown +4 more
doaj +1 more source