Results 61 to 70 of about 10,058 (131)

9-fold symmetry is not essential for centriole elongation and formation of new centriole-like structures

Nature Communications
As daughter centrioles assemble during G2, they recruit conserved Ana3/RTTN followed by its partner Rcd4/PPP1R35. Together, this contributes to the subsequent recruitment of Ana1/CEP295, required for the centriole’s conversion to a centrosome.
Pallavi Panda, Mark S. Ladinsky, David M. Glover   +2 more
doaj   +1 more source

Crystal structures of the CPAP/STIL complex reveal its role in centriole assembly and human microcephaly

eLife, 2013
Centrioles organise centrosomes and template cilia and flagella. Several centriole and centrosome proteins have been linked to microcephaly (MCPH), a neuro-developmental disease associated with small brain size. CPAP (MCPH6) and STIL (MCPH7) are required
Matthew A Cottee, Nadine Muschalik, Yao Liang Wong, Christopher M Johnson, Steven Johnson, Antonina Andreeva, Karen Oegema, Susan M Lea, Jordan W Raff, Mark van Breugel   +9 more
doaj   +1 more source

CEP128 Localizes to the Subdistal Appendages of the Mother Centriole and Regulates TGF-β/BMP Signaling at the Primary Cilium

Cell Reports, 2018
Summary: The centrosome is the main microtubule-organizing center in animal cells and comprises a mother and daughter centriole surrounded by pericentriolar material.
Maren Mönnich, Louise Borgeskov, Loretta Breslin, Lis Jakobsen, Michaela Rogowski, Canan Doganli, Jacob M. Schrøder, Johanne B. Mogensen, Louise Blinkenkjær, Lea M. Harder, Emma Lundberg, Stefan Geimer, Søren T. Christensen, Jens S. Andersen, Lars A. Larsen, Lotte B. Pedersen   +15 more
doaj   +1 more source

The HPV-16 E7 oncoprotein induces centriole multiplication through deregulation of Polo-like kinase 4 expression

Molecular Cancer, 2011
Background Infection with high-risk human papillomaviruses (HPVs) such as HPV-16 is intimately associated with squamous cell carcinomas (SCCs) of the anogenital tract and a subset of oropharyngeal carcinomas.
Duensing Stefan, Treat Benjamin, Korzeniewski Nina   +2 more
doaj   +1 more source

mTOR controls ependymal cell differentiation by targeting the alternative cell cycle and centrosomal proteins

EMBO Reports
Ependymal cells are multiciliated glial cells lining the ventricles of the mammalian brain. Their differentiation from progenitor cells involves cell enlargement and progresses through centriole amplification phases and ciliogenesis.
Alexia Bankolé, Ayush Srivastava, Asm Shihavuddin, Khaled Tighanimine, Marion Faucourt, Vonda Koka, Solene Weill, Ivan Nemazanyy, Alissa J Nelson, Matthew P Stokes, Nathalie Delgehyr, Auguste Genovesio, Alice Meunier, Stefano Fumagalli, Mario Pende, Nathalie Spassky   +15 more
doaj   +1 more source

Ultrastructures of spermatozoon tail in rice water weevil, Lissorhoptrus oryzophilus Kuschel (Coleoptera, Curculionidae)

浙江大学学报. 农业与生命科学版, 2008
Ultrastructures of spermatozoon tail in the rice water weevil, Lissorhoptrus oryzophilus, were observed via transmission electron microscopy at selected sperm developmental stages with the aim at clarifying spermiogenesis in this weevil.
HE Yan, JI Xiang-hua, JIANG Ming-xing, CHENG Jia-an   +3 more
doaj   +1 more source

Publication Only

HemaSphere, Volume 10, Issue S1, June 2026.
wiley   +1 more source

Centrioles are frequently amplified in early B cell development but dispensable for humoral immunity

Nature Communications
Centrioles define centrosome structure and function. Deregulation of centriole numbers can cause developmental defects and cancer. The p53 tumor suppressor limits the growth of cells lacking or harboring additional centrosomes and can be engaged by the ...
Marina A. Schapfl, Gina M. LoMastro, Vincent Z. Braun, Maretoshi Hirai, Michelle S. Levine, Eva Kiermaier, Verena Labi, Andrew J. Holland, Andreas Villunger   +8 more
doaj   +1 more source

Centrobin serves as a safeguard to guide timely centriole maturation during the cell cycle

Scientific Reports
Centrioles assemble and segregate in link to the cell cycle. Daughter centrioles assemble at S phase, and become young mother centrioles after M phase. Since distal appendages (DAs) are installed to young mother centrioles at the second G2/M transition ...
Dohyong Lee, Sungjin Ryu, Ji Hwa Hea, Globinna Kim, In-Jeoung Baek, Young Hoon Sung, Kunsoo Rhee   +6 more
doaj   +1 more source

Tipping the balance: synthesis and evaluation of centrinone-based degraders of polo-like kinase 4. [PDF]

RSC Chem Biol
Kovacevic A, Salim A, Borges C, Meraldi P, Hoogendoorn S.   +4 more
europepmc   +1 more source