Results 71 to 80 of about 13,342 (208)

Sperm Head–Tail Coupling Apparatus Diversity and Common Themes Among Species

Andrology, EarlyView.
ABSTRACT Background A stable connection between the sperm head (containing the nucleus and acrosome) and tail (containing the axoneme, mitochondrial sheath, and periaxonemal structures) is critical for fertility. This connection is mediated by a series of nuclear, cytoplasmic, and centriole components that make up the head–tail coupling apparatus (HTCA)
Danielle B. Buglak, Brian J. Galletta, Nasser M. Rusan   +2 more
wiley   +1 more source

An interaction network of inner centriole proteins organised by POC1A-POC1B heterodimer crosslinks ensures centriolar integrity

Nature Communications
Centriole integrity, vital for cilia formation and chromosome segregation, is crucial for human health. The inner scaffold within the centriole lumen composed of the proteins POC1B, POC5 and FAM161A is key to this integrity.
Cornelia Sala, Martin Würtz, Enrico Salvatore Atorino, Annett Neuner, Patrick Partscht, Thomas Hoffmann, Sebastian Eustermann, Elmar Schiebel   +7 more
doaj   +1 more source

A CCNA1 Missense Variant Associated With Chromatid Non‐Disjunction in Abnormal‐Headed Sperm and Male Infertility

Andrology, EarlyView.
ABSTRACT Background Macrozoospermia is a rare form of teratozoospermia characterized by tetraploids, large‐headed spermatozoa with multiple flagella, usually caused by bi‐allelic AURKC mutations. The etiology of atypical phenotypes with a lower proportion of large headed spermatozoa and single flagella however often remains unresolved.
Aurore Perrin, Frédéric Morel, Zeina Wehbe, Cynthia Frapsauce, Nadia Gueganic, Corinne Tous, Séverine Commet, Laura Dijols, Audrey Basinko, Nathalie Douet‐Guilbert, Célia Tebbakh, Zine‐Eddine Kherraf, Pierre F. Ray, Charles Coutton, Guillaume Martinez   +14 more
wiley   +1 more source

Acto-myosin force organization modulates centriole separation and PLK4 recruitment to ensure centriole fidelity [PDF]

, 2019
International audienceThe presence of aberrant number of centrioles is a recognized cause of aneuploidy and hallmark of cancer. Hence, centriole duplication needs to be tightly regulated.
Mettouchi, Amel, Nunes, V, Moreau, Philippe, Vitiello, Elisa, Ferreira, Jorge, Wang, Irène, Vitiello, E, Mettouchi, A, Nunes, Vanessa, Maiato, Helder, Wang, I, Balland, Martial, Moreau, P, Ferreira, JG, Maiato, H, Balland, M   +15 more
core   +1 more source

Self-organization of Plk4 regulates symmetry breaking in centriole duplication

Nature Communications, 2019
During centriole duplication, Plk4 regulates formation of a single daughter centriole adjacent to the mother centriole, but the mechanism is unclear. Here, the authors show that Plk4 can undergo liquid–liquid phase separation and that the condensation ...
Shohei Yamamoto, Daiju Kitagawa
doaj   +1 more source

Centriolar SAS-7 acts upstream of SPD-2 to regulate centriole assembly and pericentriolar material formation

eLife, 2017
The centriole/basal body is a eukaryotic organelle that plays essential roles in cell division and signaling. Among five known core centriole proteins, SPD-2/Cep192 is the first recruited to the site of daughter centriole formation and regulates the ...
Kenji Sugioka, Danielle R Hamill, Joshua B Lowry, Marie E McNeely, Molly Enrick, Alyssa C Richter, Lauren E Kiebler, James R Priess, Bruce Bowerman   +8 more
doaj   +1 more source

Cep63 and cep152 cooperate to ensure centriole duplication. [PDF]

PLoS ONE, 2013
Centrosomes consist of two centrioles embedded in pericentriolar material and function as the main microtubule organising centres in dividing animal cells.
Nicola J Brown, Marko Marjanović, Jens Lüders, Travis H Stracker, Vincenzo Costanzo   +4 more
doaj   +1 more source

First Insights on Photoreceptor Organ Ultrastructure in Marine Chaetonotida (Gastrotricha): Species of Xenotrichula and Draculiciteria (Xenotrichulidae)

Acta Zoologica, EarlyView.
ABSTRACT Marine gastrotrichs inhabit sediments with limited available light, yet evidence suggests that photoreceptor organs are present throughout the phylum Gastrotricha. Here, we confirm this proposition with ultrastructural descriptions of photoreceptive organs in two species of Xenotrichulidae (Order Chaetonotida) that lack pigmented ocelli ...
Thiago Quintão Araújo, Rick Hochberg
wiley   +1 more source

Dynamic centriolar localization of Polo and Centrobin in early mitosis primes centrosome asymmetry.

PLoS Biology, 2020
Centrosomes, the main microtubule organizing centers (MTOCs) of metazoan cells, contain an older "mother" and a younger "daughter" centriole. Stem cells either inherit the mother or daughter-centriole-containing centrosome, providing a possible mechanism
Emmanuel Gallaud, Anjana Ramdas Nair, Nicole Horsley, Arnaud Monnard, Priyanka Singh, Tri Thanh Pham, David Salvador Garcia, Alexia Ferrand, Clemens Cabernard   +8 more
doaj   +1 more source

The MacBrain Resource Center (MBRC) rhesus macaque embryonic brain histology datasets

Journal of Anatomy, EarlyView.
We introduce the MacBrain Resource Center (MBRC) Collections of rhesus macaque embryonic brain tissue. Here, we illustrate histo‐ and immunohistology from our dynamically growing Collection 6, which currently contains >10,000 zoomable and downloadable images from n = 14 male and female embryos from early to late in gestation.
Valeria Mendoza‐Silva, Emma Burke, Lucy Greene, Mikhail Rodov, Janja Kopić, Phil Barello, Yury M. Morozov, Keiko Moriya‐Ito, Chiaki Ohtaka‐Maruyama, Zeljka Krsnik, Pasko Rakic, Alvaro Duque   +11 more
wiley   +1 more source