Results 11 to 20 of about 51,025 (263)
Cilia and cilia-associated proteins in cancer [PDF]
Drug Discovery Today: Disease Mechanisms, 2013 The primary cilium is a well-established target in the pathogenesis of numerous developmental and chronic disorders, and more recently is attracting interest as a structure relevant to cancer. Here we discuss mechanisms by which changes in cilia can contribute to the formation and growth of tumors.
Tamina, Seeger-Nukpezah +3 more
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Journal of Cell Science, 2008 Descriptive has almost become a dirty word in modern cell biology. To describe something is viewed as a suitable pastime for the amateur, but hardly an occupation for the serious modern scientist.
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Scientific Reports, 2021 The base of the cilium comprising the transition zone (TZ) and transition fibers (TF) acts as a selecting gate to regulate the intraflagellar transport (IFT)-dependent trafficking of proteins to and from cilia.
Khodor S. Hazime +5 more
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Cells, 2019 Cilia are highly evolutionarily conserved, microtubule-based cell protrusions present in eukaryotic organisms from protists to humans, with the exception of fungi and higher plants.
Anna Osinka +5 more
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Cold Spring Harbor Perspectives in Biology, 2017 The ciliopathies Bardet-Biedl syndrome and Alström syndrome cause obesity. How ciliary dysfunction leads to obesity has remained mysterious, partly because of a lack of understanding of the physiological roles of primary cilia in the organs and pathways involved in the regulation of metabolism and energy homeostasis.
Vaisse, Christian +2 more
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ARL13B regulates Sonic hedgehog signaling from outside primary cilia
eLife, 2020 ARL13B is a regulatory GTPase highly enriched in cilia. Complete loss of Arl13b disrupts cilia architecture, protein trafficking and Sonic hedgehog signaling. To determine whether ARL13B is required within cilia, we knocked in a cilia-excluded variant of
Eduardo D Gigante +4 more
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IFT proteins spatially control the geometry of cleavage furrow ingression and lumen positioning
Nature Communications, 2017 Cytokinesis relies on central spindle organization and provides a spatial landmark for lumen formation. Here, the authors show that intraflagellar transport proteins are required for the localization of the cytokinetic regulator Aurora B and subsequent ...
Nicolas Taulet +8 more
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The Importance of Zebrafish in Biomedical Research
Acta Médica Portuguesa, 2013 Introduction: Zebrafish (Danio rerio) is an ideal model organism for the study of vertebrate development. This is due to the large clutches that each couple produces, with up to 200 embryos every 7 days, and to the fact that the embryos and larvae are ...
Bárbara Tavares, Susana Santos Lopes
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Identification and characterization of a novel allele of Caenorhabditis elegans bbs-7. [PDF]
PLoS ONE, 2014 Primary cilia play a role in the sensation of and response to the surrounding environment. Caenorhabditis elegans (C. elegans) have primary cilia only on the distal tips of some dendrites.
Kara Braunreiter +2 more
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A dynamical model of the spindle position checkpoint
Molecular Systems Biology, 2012 The orientation of the mitotic spindle with respect to the polarity axis is crucial for the accuracy of asymmetric cell division. In budding yeast, a surveillance mechanism called the spindle position checkpoint (SPOC) prevents exit from mitosis when the
Ayse Koca Caydasi +5 more
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