Results 11 to 20 of about 78,565 (291)
Ependymal cilia beating induces an actin network to protect centrioles against shear stress
Nature Communications, 2018 Ependymal ciliary beating contributes to the flow of cerebrospinal fluid in the brain ventricles and these cilia resist the flow forces. Here the authors show that the assembly of a dense actin network around the centrioles is induced by cilia beating to
Alice Meunier +2 more
exaly +2 more sources
Bardet-Biedl syndrome 1 mutations differentially impact BBSome integrity and ciliary trafficking [PDF]
Cell Communication and SignalingBackground Bardet-Biedl syndrome is a pleiotropic ciliopathy marked by retinal degeneration, obesity, polydactyly, renal and reproductive anomalies, and cognitive impairment.
Kristyna Maskova +6 more
doaj +2 more sources
Smoking Is Associated with Shortened Airway Cilia [PDF]
PLoS ONE, 2009 BACKGROUND:Whereas cilia damage and reduced cilia beat frequency have been implicated as causative of reduced mucociliary clearance in smokers, theoretically mucociliary clearance could also be affected by cilia length.
Ronald Crystal, Ben-Gary Harvey
exaly +2 more sources
Cilia-mediated signalling in the embryonic nodes: A computational fluid-structure-protein interaction (FSPI) model [PDF]
, 2009 This paper was presented at the 2nd Micro and Nano Flows Conference (MNF2009), which was held at Brunel University, West London, UK. The conference was organised by Brunel University and supported by the Institution of Mechanical Engineers, IPEM, the ...
2nd Micro and Nano Flows Conference (MNF2009) +3 more
core +6 more sources
Primary cilia disassembly down regulates mechanosensitive hedgehog signalling: a feedback mechanism controlling ADAMTS-5 expression in chondrocytes [PDF]
, 2014 SummaryObjectiveHedgehog signalling is mediated by the primary cilium and promotes cartilage degeneration in osteoarthritis. Primary cilia are influenced by pathological stimuli and cilia length and prevalence are increased in osteoarthritic cartilage ...
Knight, M.M. +5 more
core +4 more sources
Composition and function of the C1b/C1f region in the ciliary central apparatus
Scientific Reports, 2021 Motile cilia are ultrastructurally complex cell organelles with the ability to actively move. The highly conserved central apparatus of motile 9 × 2 + 2 cilia is composed of two microtubules and several large microtubule-bound projections, including the ...
Ewa Joachimiak +7 more
doaj +1 more source
Cilia and cilia-associated proteins in cancer [PDF]
Drug Discovery Today: Disease Mechanisms, 2013 The primary cilium is a well-established target in the pathogenesis of numerous developmental and chronic disorders, and more recently is attracting interest as a structure relevant to cancer. Here we discuss mechanisms by which changes in cilia can contribute to the formation and growth of tumors.
Tamina, Seeger-Nukpezah +3 more
openaire +2 more sources
Scientific Reports, 2023 Primary cilia are key regulators of embryo development and tissue homeostasis. However, their mechanisms and functions, particularly in the context of human cells, are still unclear.
Lucia Binó, Lukáš Čajánek
doaj +1 more source
Cells, 2020 Katanin-like 2 protein (Katnal2) orthologs have a tripartite domain organization. Two highly conserved regions, an N-terminal LisH (Lis-homology) domain and a C-terminal AAA catalytic domain, are separated by a less conserved linker.
Ewa Joachimiak +6 more
doaj +1 more source
Physiological Reports, 2022 Motile cilia are found in numerous locations throughout our body and play a critical role in various physiological processes. The most commonly used method to assess cilia motility is to quantify cilia beat frequency (CBF) via video microscopy.
Luke Scopulovic +3 more
doaj +1 more source