Effects of Sesquiterpene Lactones on Primary Cilia Formation (Ciliogenesis)
Toxins, 2023 Sesquiterpene lactones (SLs), plant-derived metabolites with broad spectra of biological effects, including anti-tumor and anti-inflammatory, hold promise for drug development.
Marina Murillo-Pineda +9 more
doaj +1 more source
A role for Tctex-1 (DYNLT1) in controlling primary cilium length [PDF]
, 2011 The microtubule motor complex cytoplasmic dynein is known to be involved in multiple processes including endomembrane organization and trafficking, mitosis, and microtubule organization.
MacCarthy-Morrogh, LJ +3 more
core +2 more sources
Mixing and transport by ciliary carpets: a numerical study [PDF]
, 2013 We use a 3D computational model to study the fluid transport and mixing due to the beating of an infinite array of cilia. In accord with recent experiments, we observe two distinct regions: a fluid transport region above the cilia and a fluid mixing ...
Ding, Yang +3 more
core +3 more sources
Ependymal cilia beating induces an actin network to protect centrioles against shear stress
Nature Communications, 2018 Ependymal ciliary beating contributes to the flow of cerebrospinal fluid in the brain ventricles and these cilia resist the flow forces. Here the authors show that the assembly of a dense actin network around the centrioles is induced by cilia beating to
Alexia Mahuzier +12 more
doaj +1 more source
Intrinsic and Extrinsic Factors Affecting Microtubule Dynamics in Normal and Cancer Cells
Molecules, 2020 Microtubules (MTs), highly dynamic structures composed of α- and β-tubulin heterodimers, are involved in cell movement and intracellular traffic and are essential for cell division.
Filip Borys +3 more
doaj +1 more source
Airway ciliated cells in adult lung homeostasis and COPD
European Respiratory Review, 2023 Cilia are organelles emanating from the cell surface, consisting of an axoneme of microtubules that extends from a basal body derived from the centrioles. They are either isolated and nonmotile (primary cilia), or grouped and motile (motile cilia). Cilia
Laure M.G. Petit +10 more
doaj +1 more source
Reactivation of ethanol-calcium-isolated cilia from Tetrahymena pyriformis [PDF]
, 1967 Cilia isolated from Tetrahymena after ciliary shedding is induced by the addition of CaCl2 or other salts to cells suspended in an ethanol solution (4, 6, 11) have been studied chemically and enzymatically (4, 6, 11, 12, 13), but until now have never ...
Winicur, Sandra
core +2 more sources
Subcellular localization of MC4R with ADCY3 at neuronal primary cilia underlies a common pathway for genetic predisposition to obesity. [PDF]
, 2018 Most monogenic cases of obesity in humans have been linked to mutations in genes encoding members of the leptin-melanocortin pathway. Specifically, mutations in MC4R, the melanocortin-4 receptor gene, account for 3-5% of all severe obesity cases in ...
A Hinney +38 more
core +1 more source
A boundary element regularised Stokeslet method applied to cilia and flagella-driven flow [PDF]
, 2009 A boundary element implementation of the regularised Stokeslet method of Cortez is applied to cilia and flagella-driven flows in biology. Previously-published approaches implicitly combine the force discretisation and the numerical quadrature used to ...
Burgers J. M., Gray J., Sanderson M. J.
core +1 more source
Cells, 2019 Cilia are highly evolutionarily conserved, microtubule-based cell protrusions present in eukaryotic organisms from protists to humans, with the exception of fungi and higher plants.
Anna Osinka +5 more
doaj +1 more source