Results 21 to 30 of about 128,344 (306)
ARL13B regulates Sonic hedgehog signaling from outside primary cilia
eLife, 2020 ARL13B is a regulatory GTPase highly enriched in cilia. Complete loss of Arl13b disrupts cilia architecture, protein trafficking and Sonic hedgehog signaling. To determine whether ARL13B is required within cilia, we knocked in a cilia-excluded variant of
Eduardo D Gigante +4 more
doaj +1 more source
Efficiency optimization and symmetry-breaking in a model of ciliary locomotion [PDF]
, 2010 A variety of swimming microorganisms, called ciliates, exploit the bending of a large number of small and densely-packed organelles, termed cilia, in order to propel themselves in a viscous fluid.
Lauga, Eric, Michelin, Sebastien
core +3 more sources
IFT proteins spatially control the geometry of cleavage furrow ingression and lumen positioning
Nature Communications, 2017 Cytokinesis relies on central spindle organization and provides a spatial landmark for lumen formation. Here, the authors show that intraflagellar transport proteins are required for the localization of the cytokinetic regulator Aurora B and subsequent ...
Nicolas Taulet +8 more
doaj +1 more source
Scientific Reports, 2021 The base of the cilium comprising the transition zone (TZ) and transition fibers (TF) acts as a selecting gate to regulate the intraflagellar transport (IFT)-dependent trafficking of proteins to and from cilia.
Khodor S. Hazime +5 more
doaj +1 more source
Hedgehog Pathway Activation Alters Ciliary Signaling in Primary Hypothalamic Cultures [PDF]
, 2019 Primary cilia dysfunction has been associated with hyperphagia and obesity in both ciliopathy patients and mouse models of cilia perturbation. Neurons throughout the brain possess these solitary cellular appendages, including in the feeding centers of ...
Antonellis, Patrick J. +7 more
core +1 more source
The Importance of Zebrafish in Biomedical Research
Acta Médica Portuguesa, 2013 Introduction: Zebrafish (Danio rerio) is an ideal model organism for the study of vertebrate development. This is due to the large clutches that each couple produces, with up to 200 embryos every 7 days, and to the fact that the embryos and larvae are ...
Bárbara Tavares, Susana Santos Lopes
doaj +1 more source
Identification and characterization of a novel allele of Caenorhabditis elegans bbs-7. [PDF]
PLoS ONE, 2014 Primary cilia play a role in the sensation of and response to the surrounding environment. Caenorhabditis elegans (C. elegans) have primary cilia only on the distal tips of some dendrites.
Kara Braunreiter +2 more
doaj +1 more source
Philosophical Transactions of the Royal Society B: Biological Sciences, 2019 Cilia, or eukaryotic flagella, are microscopic active filaments expressed on the surface of many eukaryotic cells, from single-celled protozoa to mammalian epithelial surfaces. Cilia are characterized by a highly conserved and intricate internal structure in which molecular motors exert forces on microtubule doublets causing cilia oscillations.
Yi Man, Feng Ling, Eva Kanso
openaire +3 more sources
A dynamical model of the spindle position checkpoint
Molecular Systems Biology, 2012 The orientation of the mitotic spindle with respect to the polarity axis is crucial for the accuracy of asymmetric cell division. In budding yeast, a surveillance mechanism called the spindle position checkpoint (SPOC) prevents exit from mitosis when the
Ayse Koca Caydasi +5 more
doaj +1 more source
The effects of acute hydrogen peroxide exposure on respiratory cilia motility and viability [PDF]
PeerJ, 2023 COVID-19 has seen the propagation of alternative remedies to treat respiratory disease, such as nebulization of hydrogen peroxide (H2O2). As H2O2 has known cytotoxicity, it was hypothesised that H2O2 inhalation would negatively impact respiratory cilia ...
Richard Francis
doaj +2 more sources