Results 41 to 50 of about 80,298 (298)

Neuronal cilia in energy homeostasis

Frontiers in Cell and Developmental Biology, 2022
A subset of genetic disorders termed ciliopathies are associated with obesity. The mechanisms behind cilia dysfunction and altered energy homeostasis in these syndromes are complex and likely involve deficits in both development and adult homeostasis ...
Kathryn M. Brewer, Katlyn K. Brewer, Nicholas C. Richardson, Nicolas F. Berbari, Nicolas F. Berbari, Nicolas F. Berbari   +5 more
doaj   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

The role of primary cilia and sonic hedgehog signalling in adrenal development function. [PDF]

, 2012
PhDPrimary cilia are sensory organelles found on most vertebrate cells during interphase. They play key roles in development, cell signalling and cancer, and are involved in signal transduction pathways such as Hh and Wnt signalling.
Cogger, Kathryn
core   +2 more sources

Pix proteins and the evolution of centrioles [PDF]

, 2008
We have made a wide phylogenetic survey of Pix proteins, which are constituents of vertebrate centrioles in most eukaryotes. We have also surveyed the presence and structure of flagella or cilia and centrioles in these organisms, as far as is possible ...
Fry, Andrew M., Woodland, Hugh R., Fry Andrew M., H. R. Woodland (7620182), Andrew M Fry, Andrew M. Fry (7589357), Woodland Hugh R., Hugh R Woodland   +7 more
core   +1 more source

Tau-tubulin kinase 2 restrains microtubule-depolymerizer KIF2A to support primary cilia growth

Cell Communication and Signaling
Background Primary cilia facilitate cellular signalling and play critical roles in development, homeostasis, and disease. Their assembly is under the control of Tau-Tubulin Kinase 2 (TTBK2), a key enzyme mutated in patients with spinocerebellar ataxia ...
David Benk Vysloužil, Ondřej Bernatík, Eva Lánská, Tereza Renzová, Lucia Binó, Andrea Lacigová, Tereza Drahošová, Zdeněk Lánský, Lukáš Čajánek   +8 more
doaj   +1 more source

IFT46 Expression in the Nasal Mucosa of Primary Ciliary Dyskinesia Patients: Preliminary Study

Allergy & Rhinology, 2021
Background Primary ciliary dyskinesia (PCD) is characterised by an imbalance in mucociliary clearance leading to chronic respiratory infections. Cilia length is considered to be a contributing factor in cilia movement.
Manuel Mata PhD, Javier Zurriaga PhD, Lara Milian PhD, Ana Reula PhD, Miguel Armengot PhD, Amparo Ruiz-Sauri PhD, Carmen Carda PhD   +6 more
doaj   +1 more source

A Holistic Platform Approach for Developing Robust Pulmonary mRNA Delivery: Integrating Novel Phenolic Acid‐Derived Ionizable Lipids and Device Engineering

Advanced Functional Materials, EarlyView.
An integrated pulmonary mRNA delivery platform combining novel biodegradable syringic acid‐derived ionizable lipids, design‐of‐experiments formulation optimization, and vibrating‐mesh nebulizer engineering enabled stable aerosolization and efficient lung delivery.
Neha Kaushal, Younan Ma, Asad Khanmohammed, Dipen Parande, Hanming Zhang, Saket Dolare, Juliet Chen, Apiwat Wangweerawong, Saswata Karmakar, Hongfeng Deng, Frank Koppenhagen, Shraddha Sharma, Eric Reyes, Sherry He, Lianne Boeglin, Caroline Woo, Azadeh Paksa, Ayed Allawzi, Anusha Dias, Gregory Troiano, Shrirang Karve, Frank DeRosa   +21 more
wiley   +1 more source

Bardet-Biedl syndrome 1 mutations differentially impact BBSome integrity and ciliary trafficking

Cell Communication and Signaling
Background Bardet-Biedl syndrome is a pleiotropic ciliopathy marked by retinal degeneration, obesity, polydactyly, renal and reproductive anomalies, and cognitive impairment.
Kristyna Maskova, Hana Hajsmanova, Sofiia Bykova, Sindija Smite, Avishek Prasai, Daniel Rozbesky, Martina Huranova   +6 more
doaj   +1 more source

Diverged morphology changes of astrocytic and neuronal primary cilia under reactive insults

Molecular Brain, 2020
Primary cilia are centriole-derived sensory organelles that are present in most mammalian cells, including astrocytes and neurons. Evidence is emerging that astrocyte and neuronal primary cilia demonstrate a dichotomy in the mature mouse brain.
Ashley Sterpka, Juan Yang, Matthew Strobel, Yuxin Zhou, Connor Pauplis, Xuanmao Chen   +5 more
doaj   +1 more source

Loss of Deacetylation Enzymes Hdac6 and Sirt2 Promotes Acetylation of Cytoplasmic Tubulin, but Suppresses Axonemal Acetylation in Zebrafish Cilia

Frontiers in Cell and Developmental Biology, 2021
Cilia are evolutionarily highly conserved organelles with important functions in many organs. The extracellular component of the cilium protruding from the plasma membrane comprises an axoneme composed of microtubule doublets, arranged in a 9 + 0 ...
Paweł K. Łysyganicz, Paweł K. Łysyganicz, Niedharsan Pooranachandran, Xinming Liu, Kathryn I. Adamson, Kathryn I. Adamson, Katarzyna Zielonka, Katarzyna Zielonka, Stone Elworthy, Stone Elworthy, Fredericus J. van Eeden, Fredericus J. van Eeden, Andrew J. Grierson, Andrew J. Grierson, Jarema J. Malicki, Jarema J. Malicki   +15 more
doaj   +1 more source