The actin regulator profilin 1 is functionally associated with the mammalian centrosome
Life Science Alliance, 2021 The actin regulator profilin 1 recently shown to control microtubule elongation at the cell periphery is found to interact with the γ-tubulin ring complex and tune centrosomal microtubule nucleation.
Michaela Nejedlá +6 more
doaj +1 more source
Sensor potency of the moonlighting enzyme-decorated cytoskeleton [PDF]
, 2013 Background: There is extensive evidence for the interaction of metabolic enzymes with the eukaryotic cytoskeleton. The significance of these interactions is far from clear.
Amar Patrick +5 more
core +4 more sources
Effects of plasma membrane cholesterol level and cytoskeleton F-actin on cell protrusion mechanics. [PDF]
, 2013 Protrusions are deformations that form at the surface of living cells during biological activities such as cell migration. Using combined optical tweezers and fluorescent microscopy, we quantified the mechanical properties of protrusions in adherent ...
Anvari, Bahman +3 more
core +6 more sources
Identifying Regulatory Posttranslational Modifications of PD-L1: A Focus on Monoubiquitinaton
Neoplasia: An International Journal for Oncology Research, 2017 A set of high-affinity, high-specificity posttranslational modification (PTM) enrichment tools was developed to generate an unbiased snapshot of four key PTM profiles (tyrosine phosphorylation, acetylation, ubiquitination, and SUMOylation 2/3) for the ...
Henrick Horita +3 more
doaj +1 more source
Models of dynamic extraction of lipid tethers from cell membranes [PDF]
, 2010 When a ligand that is bound to an integral membrane receptor is pulled, the membrane and the underlying cytoskeleton can deform before either the membrane delaminates from the cytoskeleton or the ligand detaches from the receptor.
Cuvelier D +4 more
core +1 more source
Frontiers in Immunology, 2021 Natural killer (NK) cells are innate effector lymphocytes with strong antitumor effects against hematologic malignancies such as chronic lymphocytic leukemia (CLL). However, NK cells fail to control CLL progression on the long term.
Hannah Wurzer +16 more
doaj +1 more source
Focal adhesions as mechanosensors: the two-spring model [PDF]
, 2004 Adhesion-dependent cells actively sense the mechanical properties of their environment through mechanotransductory processes at focal adhesions, which are integrin-based contacts connecting the extracellular matrix to the cytoskeleton.
Schwarz, Ulrich S. +2 more
core +3 more sources
Actin cytoskeleton-dependent regulation of corticotropin-releasing factor receptor heteromers [PDF]
, 2017 Stress responses are highly nuanced and variable, but how this diversity is achieved by modulating receptor function is largely unknown. Corticotropin-releasing factor receptors (CRFRs), class B G protein–coupled receptors, are pivotal in mediating ...
Bhargava, Aditi +7 more
core +1 more source
cis-acting sequences and trans-acting factors in the localization of mRNA for mitochondrial ribosomal proteins [PDF]
, 2008 mRNA localization is a conserved post-transcriptional process crucial for a variety of systems. Although several mechanisms have been identified, emerging evidence suggests that most transcripts reach the protein functional site by moving along ...
AMORESANO, ANGELA +5 more
core +1 more source
Tobacco WLIM1 is a novel F-actin binding protein involved in actin cytoskeleton remodeling [PDF]
, 2006 We used confocal microscopy and in vitro analyses to show that Nicotiana tabacum WLIM1, a LIM domain protein related to animal Cys-rich proteins, is a novel actin binding protein in plants.
Thomas, Clément +5 more
core +2 more sources