Results 21 to 30 of about 271,491 (266)
Scientific Reports, 2021 The base of the cilium comprising the transition zone (TZ) and transition fibers (TF) acts as a selecting gate to regulate the intraflagellar transport (IFT)-dependent trafficking of proteins to and from cilia.
Khodor S. Hazime +5 more
doaj +1 more source
Regulation of actin cytoskeleton via photolithographic micropatterning
Journal of Innovative Optical Health Sciences, 2023 Actin cytoskeleton plays crucial roles in various cellular functions. Extracellular matrix (ECM) can modulate cell morphology by remodeling the internal cytoskeleton.
Fulin Xing +9 more
doaj +1 more source
Frontiers in Immunology, 2018 Mast cells play an effector role in innate immunity, allergy, and inflammation. Antigen-mediated activation of mast cells initiates signaling events leading to Ca2+ response and the release of inflammatory and allergic mediators from granules.
Zuzana Rubíková +3 more
doaj +1 more source
Kinetochore- and chromosome-driven transition of microtubules into bundles promotes spindle assembly
Nature Communications, 2022 Mitotic spindle assembly is not fully understood. This work reveals that kinetochores drive the coarsening of a uniform microtubule array into bundles, which promote spindle formation and chromosome segregation fidelity.
Jurica Matković +6 more
doaj +1 more source
First-in-Class Colchicine-Based Visible Light Photoswitchable Microtubule Dynamics Disrupting Agent
Cells, 2023 Compounds that disrupt microtubule dynamics, such as colchicine, paclitaxel, or Vinca alkaloids, have been broadly used in biological studies and have found application in clinical anticancer medications.
Filip Borys +4 more
doaj +1 more source
Cells, 2019 The immune system is a fundamental part of the tumor microenvironment. In particular, cytotoxic lymphocytes, such as cytolytic T cells and natural killer cells, control tumor growth and disease progression by interacting and eliminating tumor cells.
Hannah Wurzer +3 more
doaj +1 more source
Intrinsic and Extrinsic Factors Affecting Microtubule Dynamics in Normal and Cancer Cells
Molecules, 2020 Microtubules (MTs), highly dynamic structures composed of α- and β-tubulin heterodimers, are involved in cell movement and intracellular traffic and are essential for cell division.
Filip Borys +3 more
doaj +1 more source
Frontiers in Pharmacology, 2020 Agents able to modify microtubule dynamics are important anticancer drugs. The absence of microtubules resulting from drug-induced depolymerization is easy to detect.
Sacnicte Ramirez-Rios +9 more
doaj +1 more source
Prognostic significance of CKAP2L expression in patients with clear cell renal cell carcinoma
Frontiers in Genetics, 2023 Background: Cytoskeleton-associated protein 2-like protein (CKAP2L) is thought to promote the progression of glioma, breast cancer, and ovarian cancer. However, the role of cytoskeleton-associated protein 2-like protein in clear cell renal cell carcinoma
Zhi Liu +6 more
doaj +1 more source
Cells, 2019 Cilia are highly evolutionarily conserved, microtubule-based cell protrusions present in eukaryotic organisms from protists to humans, with the exception of fungi and higher plants.
Anna Osinka +5 more
doaj +1 more source