Results 41 to 50 of about 349,430 (309)

SILAC-based proteomic quantification of chemoattractant-induced cytoskeleton dynamics on a second to minute timescale [PDF]

, 2014
Cytoskeletal dynamics during cell behaviours ranging from endocytosis and exocytosis to cell division and movement is controlled by a complex network of signalling pathways, the full details of which are as yet unresolved.
Sobczyk, Grzegorz J., Weijer, Cornelis J.; id_orcid, Wang, Jun   +2 more
core   +1 more source

A New Quantitative Cell-Based Assay Reveals Unexpected Microtubule Stabilizing Activity of Certain Kinase Inhibitors, Clinically Approved or in the Process of Approval

Frontiers in Pharmacology, 2020
Agents able to modify microtubule dynamics are important anticancer drugs. The absence of microtubules resulting from drug-induced depolymerization is easy to detect.
Sacnicte Ramirez-Rios, Sophie Michallet, Leticia Peris, Caroline Barette, Clotilde Rabat, Yangbo Feng, Marie-Odile Fauvarque, Annie Andrieux, Karin Sadoul, Laurence Lafanechère   +9 more
doaj   +1 more source

Prognostic significance of CKAP2L expression in patients with clear cell renal cell carcinoma

Frontiers in Genetics, 2023
Background: Cytoskeleton-associated protein 2-like protein (CKAP2L) is thought to promote the progression of glioma, breast cancer, and ovarian cancer. However, the role of cytoskeleton-associated protein 2-like protein in clear cell renal cell carcinoma
Zhi Liu, Jun Zhang, Deyun Shen, Xuechun Hu, Zongpan Ke, I Nyoman Ehrich Lister, Bungaran Sihombing   +6 more
doaj   +1 more source

Analysis of CD44-containing lipid rafts: Recruitment of annexin II and stabilization by the actin cytoskeleton [PDF]

, 1999
CD44, the major cell surface receptor for hyaluronic acid (HA), was shown to localize to detergent-resistant cholesterol-rich microdomains, called lipid rafts, in fibroblasts and blood cells.
Ursula Günthert, Günthert, U., Huber, L. A., Beug, H., Hartmut Beug, Gerke, V., Thomas Harder, Paiha, K., Volker Gerke, Oliferenko, S., Schwarz, H., Karin Paiha, Heinz Schwarz, Harder, T., Snezhana Oliferenko, Lukas A. Huber, Christoph Schwärzler, Schwärzler, C.   +17 more
core   +1 more source

Ciliary Proteins: Filling the Gaps. Recent Advances in Deciphering the Protein Composition of Motile Ciliary Complexes

Cells, 2019
Cilia are highly evolutionarily conserved, microtubule-based cell protrusions present in eukaryotic organisms from protists to humans, with the exception of fungi and higher plants.
Anna Osinka, Martyna Poprzeczko, Magdalena M. Zielinska, Hanna Fabczak, Ewa Joachimiak, Dorota Wloga   +5 more
doaj   +1 more source

DNA damage and repair: underlying mechanisms leading to microcephaly

Frontiers in Cell and Developmental Biology, 2023
DNA-damaging agents and endogenous DNA damage constantly harm genome integrity. Under genotoxic stress conditions, the DNA damage response (DDR) machinery is crucial in repairing lesions and preventing mutations in the basic structure of the DNA ...
Jessica Honorato Ribeiro, Jessica Honorato Ribeiro, Nazlican Altinisik, Nicholas Rajan, Mieke Verslegers, Sarah Baatout, Sarah Baatout, Jay Gopalakrishnan, Roel Quintens   +8 more
doaj   +1 more source

A dynamic microtubule cytoskeleton directs medial actomyosin function during tube formation [PDF]

, 2014
The cytoskeleton is a major determinant of cell-shape changes that drive the formation of complex tissues during development. Important roles for actomyosin during tissue morphogenesis have been identified, but the role of the microtubule cytoskeleton is
Blanchard, Guy B., Adams, Richard J., Röper, Katja, Booth, Alexander J. R.   +3 more
core   +1 more source

Stereotactic Body Radiotherapy and Conventional Radiotherapy Induce Cytoskeleton Extension and Enlargement of Cell Morphology in Non-Small Cell Lung Cancer

Dose-Response, 2021
Stereotactic body radiotherapy (SBRT) is now widely used in cancer therapy. However, the biological effects of SBRT compared with conventional radiotherapy (CRT) are not clear.
Xiao Wang, Yanwei Lu, Zhiquan Qin, Haiwei Guo, Wenjuan Chen, Ting Ding, Jianming Tang, Haibo Zhang   +7 more
doaj   +1 more source

Superficial and deep changes of cellular mechanical properties following cytoskeleton disassembly.

, 2005
The cytoskeleton, composed of actin filaments, intermediate filaments, and microtubules, is a highly dynamic supramolecular network actively involved in many essential biological mechanisms such as cellular structure, transport, movements ...
Forrò, L., Kasas, S., Regazzi, R., Huni, B., Catsicas, S., Marsault, R., Yersin, A., Wang, X., Grenningloh, G., Riederer, B., Hirling, H., Dietler, G.   +11 more
core   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source