Results 51 to 60 of about 321,372 (214)

Distinct Neurotoxicity Profile of Listeriolysin O from Listeria monocytogenes

Toxins, 2017
Cholesterol-dependent cytolysins (CDCs) are protein toxins that originate from Gram-positive bacteria and contribute substantially to their pathogenicity. CDCs bind membrane cholesterol and build prepores and lytic pores.
Jana Maurer, Sabrina Hupp, Carolin Bischoff, Christina Foertsch, Timothy J. Mitchell, Trinad Chakraborty, Asparouh I. Iliev   +6 more
doaj   +1 more source

Stabilization of the cortical cytoskeleton by the lipid raft-associated protein cap23 [PDF]

, 2006
In the present work, we identified the lipid raft-associated protein Cap23 to be involved in several important neuronal functions like the organization of lipid raft platforms, the maturation and stabilization of the actin- and intermediate filament ...
Wacha, Stefan
core   +1 more source

Evolution of the cytoskeleton [PDF]

BioEssays, 2007
AbstractThe eukaryotic cytoskeleton appears to have evolved from ancestral precursors related to prokaryotic FtsZ and MreB. FtsZ and MreB show 40–50% sequence identity across different bacterial and archaeal species. Here I suggest that this represents the limit of divergence that is consistent with maintaining their functions for cytokinesis and cell ...
openaire   +2 more sources

A functional link between the actin cytoskeleton and lipid rafts during budding of filamentous influenza virions

, 2002
Morphogenesis of influenza virus is a poorly understood process that produces two types of enveloped virion: approximately 100-nm spheres and similar diameter filaments that reach 20 microm in length. Spherical particles assemble at plasma membrane lipid
Paul Digard, Simpson-Holley, Martha, McCauley, John, Debra Elton, Ellis, Darren, John McCauley, Darren Ellis, Digard, Paul, Martha Simpson-Holley, Fisher, Dawn, Elton, Debra, Dawn Fisher   +11 more
core   +1 more source

Is the tumor cell side of the immunological synapse a polarized secretory domain?

Frontiers in Immunology
The formation of a lytic immunological synapse (IS) is crucial for cytotoxic lymphocytes to accurately target and effectively eliminate malignant cells. While significant attention has been focused on the lymphocyte side of the IS, particularly its role ...
Andrea Michela Biolato, Andrea Michela Biolato, Liza Filali, Diogo Pereira Fernandes, Diogo Pereira Fernandes, Flora Moreau, Takouhie Mgrditchian, Céline Hoffmann, Céline Hoffmann, Clément Thomas   +9 more
doaj   +1 more source

Visualization of Endothelial Actin Cytoskeleton in the Mouse Retina [PDF]

, 2012
Angiogenesis requires coordinated changes in cell shape of endothelial cells (ECs), orchestrated by the actin cytoskeleton. The mechanisms that regulate this rearrangement in vivo are poorly understood - largely because of the difficulty to visualize ...
Aszodi, Attila, Emanuel Rognoni (124910), Rehberg, Markus, Montanez Eloi, Eloi Montanez (124926), Rognoni Emanuel, Franco, C.A., Emanuel Rognoni, Neto, F, Aszodi Attila, Neto, Filipa, Claudio A. Franco, Rehberg Markus, Alessia Fraccaroli, Fraccaroli Alessia, Gerhardt Holger, Gerhardt, H, Roland Wedlich-Söldner, Montanez, E., Rognoni, E., Montanez, E, Claudio A. Franco (124909), Wedlich-Söldner, Roland, Fraccaroli, A., Filipa, N., Franco Claudio A., Attila Aszodi, Gerhardt, Holger, Neto, F., Alessia Fraccaroli (124908), Holger Gerhardt (124923), Montanez, Eloi, Filipa Neto (124912), Fraccaroli, Alessia, Aszodi, A., Rognoni, E, Claudio A Franco, Filipa Neto, Franco, Claudio A., Wedlich-Söldner Roland, Ulrich Pohl (124920), Markus Rehberg, Pohl, U, Aszodi, A, Wedlich-Söldner, R., Neto Filipa, Pohl, U., Eloi Montanez, Pohl Ulrich, Franco, C., Wedlich-Söldner, R, Holger Gerhardt, Ulrich Pohl, Franco, CA, Pohl, Ulrich, Markus Rehberg (124914), Rehberg, M., Gerhardt, H., Roland Wedlich-Söldner (124918), Rognoni, Emanuel, Attila Aszodi (124916), Fraccaroli, A, Rehberg, M   +62 more
core   +1 more source

A Podocyte view on RhoGTPases and actin cytoskeleton regulation [PDF]

, 2020
Proteinuria is a hallmark symptom of chronic kidney disease, that if left to persist constitutes a risk for progression of disease. Symptomatic treatment aiming at decreasing proteinuria is therefore standard practice.
Bergwall, Lovisa
core   +1 more source

Parthenolide disrupts mitosis by inhibiting ZNF207/BUGZ-promoted kinetochore-microtubule attachment

The EMBO Journal
Parthenolide is a natural compound that has shown highly promising anticancer activity. Even though its mode of action has been studied for decades, its antimitotic activity has been largely overlooked, limiting the understanding of its full anticancer ...
Susana Eibes, R Bhagya Lakshmi, Girish Rajendraprasad, Brian T Weinert, Fadhil S Kamounah, Luke F Gamon, Sergi Rodriguez-Calado, Morten Meldal, Michael J Davies, Michael Pittelkow, Chunaram Choudhary, Marin Barisic   +11 more
doaj   +1 more source

Regulation of microtubule nucleation in mouse bone marrow-derived mast cells by ARF GTPase-activating protein GIT2

Frontiers in Immunology
Aggregation of high-affinity IgE receptors (FcϵRIs) on granulated mast cells triggers signaling pathways leading to a calcium response and release of inflammatory mediators from secretory granules.
Vadym Sulimenko, Vladimíra Sládková, Tetyana Sulimenko, Eduarda Dráberová, Věra Vosecká, Lubica Dráberová, Omar Skalli, Pavel Dráber   +7 more
doaj   +1 more source

Analysis of WNK2 regulating cytoskeleton formation in ovarian cancer cells based on phosphorylation modification sequencing

Di-san junyi daxue xuebao, 2022
Objective To analyze the biological processes regulated by protein kinase WNK2 in ovarian cancer cells based on protein phosphorylation modified mass spectrometry. Methods Ovarian cancer cell line SKOV3 was transfected with lentiviral vector to knockdown
LI Fengjie, JIA Yongqin, LIANG Zhen, HU Bin, HE Simin   +4 more
doaj   +1 more source