Results 71 to 80 of about 343,555 (313)

Cytoskeletons in prokaryotes

Cell Biology International, 2003
AbstractNot only eukaryotes, but also prokaryotes possess a cytoskeleton. Tubulin‐related bacterial protein FtsZ, and actin‐related bacterial proteins MreB/Mbl have recently been described as constituents of bacterial cytoskeletons. Genes coding for MreB/Mbl could only be found in elongated bacteria, not in coccoid forms.
openaire   +3 more sources

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

Cell proliferation, cell shape, and microtubule and cellulose microfibril organization of tobacco BY-2 cells are not altered by exposure to near weightlessness in space [PDF]

, 2009
The microtubule cytoskeleton and the cell wall both play key roles in plant cell growth and division, determining the plant’s final stature. At near weightlessness, tubulin polymerizes into microtubules in vitro, but these microtubules do not self ...
Emons, A.M.C., Jan W. Vos, Emons, A.M.C. (Anne Mie), Anne Mie C. Emons, Kieft, H., Sieberer, B., Vos, J.W., Franssen-Verheijen, M.A.W., Tiny Franssen-Verheijen, Björn J. Sieberer, Vos, J.W. (Jan), Sieberer, B.J., Henk Kieft, Franssen-Verheijen, T.   +13 more
core   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Parthenolide disrupts mitosis by inhibiting ZNF207/BUGZ-promoted kinetochore-microtubule attachment

The EMBO Journal
Parthenolide is a natural compound that has shown highly promising anticancer activity. Even though its mode of action has been studied for decades, its antimitotic activity has been largely overlooked, limiting the understanding of its full anticancer ...
Susana Eibes, R Bhagya Lakshmi, Girish Rajendraprasad, Brian T Weinert, Fadhil S Kamounah, Luke F Gamon, Sergi Rodriguez-Calado, Morten Meldal, Michael J Davies, Michael Pittelkow, Chunaram Choudhary, Marin Barisic   +11 more
doaj   +1 more source

Regulation of microtubule nucleation in mouse bone marrow-derived mast cells by ARF GTPase-activating protein GIT2

Frontiers in Immunology
Aggregation of high-affinity IgE receptors (FcϵRIs) on granulated mast cells triggers signaling pathways leading to a calcium response and release of inflammatory mediators from secretory granules.
Vadym Sulimenko, Vladimíra Sládková, Tetyana Sulimenko, Eduarda Dráberová, Věra Vosecká, Lubica Dráberová, Omar Skalli, Pavel Dráber   +7 more
doaj   +1 more source

Trans-scale granular modelling of cytoskeleton: A mini-review [PDF]

, 2015
Free to read\ud \ud Living cells are the functional unit of organs that controls reactions to their exterior. However, the mechanics of living cells can be difficult to characterize due to the crypticity of their microscale structures and associated ...
Yarlagadda, Prasad K., Thibbotuwawa, Namal, Li, Tong, Yarlagadda, Prasad K. D. V., Oloyede, Adekunle, YuanTong Gu, Prasad KDV Yarlagadda, Gu, YuanTong, Tong Li, Adekunle Oloyede, Namal Thibbotuwawa   +10 more
core   +2 more sources

Visualization and Manipulation of Actin Cytoskeleton with Small-Molecular Probes [PDF]

, 2020
Actin is a ubiquitous cytoskeletal protein, forming a dynamic network that generates mechanical forces in the cell. Here, in order to dissect the complex mechanisms of actin-related cellular functions, we introduce two powerful tools based on a new class
Keisuke, Ikawa, Tetsuo, Nagano, Yusuke, Nomura, Chika, Okimura, Kaoru, Sugimura, Kenjiro, Hanaoka, Toru, Komatsu, Yoshiaki, Iwadate, Daisuke, Asanuma, Kenzo, Hirose, Tasuku, Ueno, Shin-nosuke, Uno, Mako, Kamiya, Yasuteru, Urano, Takeru, Takagi   +14 more
core   +2 more sources

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

Analysis of WNK2 regulating cytoskeleton formation in ovarian cancer cells based on phosphorylation modification sequencing

Di-san junyi daxue xuebao, 2022
Objective To analyze the biological processes regulated by protein kinase WNK2 in ovarian cancer cells based on protein phosphorylation modified mass spectrometry. Methods Ovarian cancer cell line SKOV3 was transfected with lentiviral vector to knockdown
LI Fengjie, JIA Yongqin, LIANG Zhen, HU Bin, HE Simin   +4 more
doaj   +1 more source