Results 41 to 50 of about 39,736 (248)
Dynein promotes sustained axonal growth and Schwann cell remodeling early during peripheral nerve regeneration. [PDF]
PLoS Genetics, 2019 Following injury, axons of the peripheral nervous system have retained the capacity for regeneration. While it is well established that injury signals require molecular motors for their transport from the injury site to the nucleus, whether kinesin and ...
Melissa Ducommun Priest +3 more
doaj +1 more source
The retrograde IFT machinery of C. elegans cilia: two IFT dynein complexes? [PDF]
PLoS ONE, 2011 We analyzed the relatively poorly understood IFT-dynein (class DYNC2)-driven retrograde IFT pathway in C. elegans cilia, which yielded results that are surprising in the context of current models of IFT. Assays of C.
Limin Hao +3 more
doaj +1 more source
Chemical Biology of Dynein [PDF]
, 2020 Cytoplasmic dynein is a AAA (ATPase Associated with various Activities) motor protein that transports cellular cargoes towards the microtubule minus-end.
Santarossa, Cristina C
core +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
, 2019 (A) Analysis of budded cells with an unsegregated nucleus in the wild-type CNVY108 and bim1Δ CNNV107 cells expressing histone H4-GFP. Bar, 5μm (left). The cells with nucleus remained unsegregated in the mother bud or at the neck in the bim1Δ cells with ...
Subhendu Som (6336227) +6 more
core +1 more source
TCTEX1D2 is essential for sperm flagellum formation in mice
Scientific ReportsFlagella and cilia are widely conserved motile structures, in mammalian, sperm possess flagella. Large protein complexes called dynein, including cytoplasmic dynein 2 and axonemal dynein, play a role in the formation of cilia and flagella.
Ryua Harima +2 more
doaj +1 more source
Versatile properties of dynein molecules underlying regulation in flagellar oscillation
Scientific Reports, 2023 Dynein is a minus-end-directed motor that generates oscillatory motion in eukaryotic flagella. Cyclic beating, which is the most significant feature of a flagellum, occurs by sliding spatiotemporal regulation by dynein along microtubules.
Takashi Fujiwara +2 more
doaj +1 more source
FEBS Open Bio, EarlyView.The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley +1 more source
Visualization of dynein-dependent microtubule gliding at the cell cortex: implications for spindle positioning [PDF]
, 2011 Dynein motors move along the microtubule (MT) lattice in a processive “walking” manner. In the one-cell Caenorhabditis elegans embryo, dynein is required for spindle-pulling forces during mitosis.
Srayko, M., Gusnowski, E.M.
core +1 more source
Reversible Tuning of Multiple Molecular Kinking for Stem Cell Regulation In Vivo
Advanced Functional Materials, EarlyView.In this work, we introduce the novel concept of background component‐free “multiple kinks” material platform composed solely of liganded multiple kink‐bearing molecules as a strategy for dynamic biomaterial design. Tri‐kink molecules enable effective near‐infrared light‐triggered ligand masking and visible light‐triggered ligand exposure, thereby ...
Kanghyeon Kim +28 more
wiley +1 more source