Results 41 to 50 of about 37,129 (243)

Versatile properties of dynein molecules underlying regulation in flagellar oscillation

Scientific Reports, 2023
Dynein is a minus-end-directed motor that generates oscillatory motion in eukaryotic flagella. Cyclic beating, which is the most significant feature of a flagellum, occurs by sliding spatiotemporal regulation by dynein along microtubules.
Takashi Fujiwara, Chikako Shingyoji, Hideo Higuchi   +2 more
doaj   +1 more source

Regulation of in vivo dynein force production by CDK5 and 14-3-3ε and KIAA0528

Nature Communications, 2019
Dynein plays roles in vesicular, organelle, chromosomal and nuclear transport but so far it is unclear how dynein activity in cells is regulated. Here authors study several dynein cofactors and their role in force adaptation of dynein during lipid ...
Dail E. Chapman, Babu J. N. Reddy, Bunchhin Huy, Matthew J. Bovyn, Stephen John S. Cruz, Zahraa M. Al-Shammari, Han Han, Wenqi Wang, Deanna S. Smith, Steven P. Gross   +9 more
doaj   +1 more source

The retrograde IFT machinery of C. elegans cilia: two IFT dynein complexes? [PDF]

PLoS ONE, 2011
We analyzed the relatively poorly understood IFT-dynein (class DYNC2)-driven retrograde IFT pathway in C. elegans cilia, which yielded results that are surprising in the context of current models of IFT. Assays of C.
Limin Hao, Evgeni Efimenko, Peter Swoboda, Jonathan M Scholey   +3 more
doaj   +1 more source

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

Dynein at the nuclear envelope [PDF]

EMBO reports, 2010
Most cellular organelles are positioned through active transport by motor proteins. The authors discuss the evidence that dynein has important cell cycle‐regulated functions in this context at the nuclear envelope.
Tanenbaum, M.E., Akhmanova, A.S., Medema, R.H.   +2 more
openaire   +4 more sources

Ipl1-dependent microtubule integrity and Bim1-dynein-mediated effective bias ensure timely MTOC clustering and nuclear migration.

, 2019
(A) Analysis of budded cells with an unsegregated nucleus in the wild-type CNVY108 and bim1Δ CNNV107 cells expressing histone H4-GFP. Bar, 5μm (left). The cells with nucleus remained unsegregated in the mother bud or at the neck in the bim1Δ cells with ...
Subhendu Som (6336227), Dibyendu Bhattacharyya (184588), Raja Paul (594399), Shreyas Sridhar (6336230), Kaustuv Sanyal (169834), Neha Varshney (6336224), Saptarshi Chatterjee (1750480)   +6 more
core   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Dynein and Dynactin Leverage Their Bivalent Character to Form a High-Affinity Interaction

, 2013
Amanda E. Siglin is with Thomas Jefferson University, Shangjin Sun is with University of Delaware, Jeffrey K. Moore is with Washington University in Saint Louis, Sarah Tan is with UT Austin, Martin Poenie is with UT Austin, James D.
Shangjin Sun (399678), Tatyana Polenova, Lear James D., Tan Sarah, Shangjin Sun, Polenova, Tatyana, James D Lear, Martin Poenie, Lear, James D, Williams John C., Amanda E Siglin, Williams, John C, John C. Williams (262561), Cooper, John A., Siglin, Amanda E., Lear, James D., Tatyana Polenova (226142), Sun Shangjin, Williams, John C., Sarah Tan, Martin Poenie (399681), James D. Lear (399682), Siglin, Amanda E, Sarah Tan (399680), Tan, Sarah, John C Williams, Sun, Shangjin, Moore, Jeffrey K., Cooper, John A, Siglin Amanda E., John A Cooper, Amanda E. Siglin (399677), Jeffrey K Moore, Cooper John A., Polenova Tatyana, Poenie Martin, Poenie, Martin, John A. Cooper (170679), Moore Jeffrey K., Moore, Jeffrey K, Jeffrey K. Moore (399679)   +40 more
core   +1 more source

Analyses of Dynein Heavy Chain Mutations Reveal Complex Interactions Between Dynein Motor Domains and Cellular Dynein Functions

, 2012
Cytoplasmic dynein transports cargoes for a variety of crucial cellular functions. However, since dynein is essential in most eukaryotic organisms, the in-depth study of the cellular function of dynein via genetic analysis of dynein mutations has not ...
Razafsky, David S., Schnittker, Robert R., Plamann, Michael D., Nandini, Swaran, Sivagurunathan, Senthilkumar   +4 more
core   +2 more sources

TCTEX1D2 is essential for sperm flagellum formation in mice

Scientific Reports
Flagella and cilia are widely conserved motile structures, in mammalian, sperm possess flagella. Large protein complexes called dynein, including cytoplasmic dynein 2 and axonemal dynein, play a role in the formation of cilia and flagella.
Ryua Harima, Kenshiro Hara, Kentaro Tanemura   +2 more
doaj   +1 more source