Results 41 to 50 of about 40,058 (207)

TCTEX1D2 is essential for sperm flagellum formation in mice

Scientific Reports
Flagella and cilia are widely conserved motile structures, in mammalian, sperm possess flagella. Large protein complexes called dynein, including cytoplasmic dynein 2 and axonemal dynein, play a role in the formation of cilia and flagella.
Ryua Harima, Kenshiro Hara, Kentaro Tanemura   +2 more
doaj   +1 more source

The retrograde IFT machinery of C. elegans cilia: two IFT dynein complexes? [PDF]

PLoS ONE, 2011
We analyzed the relatively poorly understood IFT-dynein (class DYNC2)-driven retrograde IFT pathway in C. elegans cilia, which yielded results that are surprising in the context of current models of IFT. Assays of C.
Limin Hao, Evgeni Efimenko, Peter Swoboda, Jonathan M Scholey   +3 more
doaj   +1 more source

A Biofabricated Human Acinus‐on‐a‐Chip Unveils Mechanotransductive Drivers of Ventilator‐Induced Lung Injury via Decoupling Volutrauma and Barotrauma

Advanced Science, EarlyView.
This bioinspired acinus‐on‐a‐chip recapitulates VILI pathology, revealing that volutrauma drives P53/NF‐κB pathways while barotrauma triggers mitochondrial‐Wnt dysregulation. A fibrotic transitional cell cluster was identified. Pharmacological interventions targeting these pathways significantly ameliorated injury, establishing a mechanobiological ...
Heng Lu, Liansheng Liu, Zengyong Hu, Shuxian Fang, Ruohan Ren, Sidi Liu, Meng Zhao, Zhiting Luo, Ziyue Zhang, Wenlong Shao, Qian Liu   +10 more
wiley   +1 more source

Palmitoyl Acyltransferase Zdhhc17 Promotes Functional Recovery After Spinal Cord Injury by Targeting the Nuclear Transport Factors Kpna2 and Ipo9

Advanced Science, EarlyView.
In this study, we demonstrate that Zdhhc17, acting as a PAT, suppresses neuronal apoptosis and promotes axon regeneration after injury, thereby enhancing functional recovery following SCI. In this context, Kpna2 and Ipo9 serve as novel palmitoylation substrates of Zdhhc17, whose palmitoylation prevents the injury‐induced degradation of their proteins ...
Meixuan Chen, Huan Chen, Sining Ding, Fan Liu, Xiaofei Zheng, Yuan Wang, Ruitu Tian, Huan Li, Peilin Liu, Le Hu, Bin Liu, Limin Rong, Mangmang Li   +12 more
wiley   +1 more source

Chemical Biology of Dynein [PDF]

, 2020
Cytoplasmic dynein is a AAA (ATPase Associated with various Activities) motor protein that transports cellular cargoes towards the microtubule minus-end.
Santarossa, Cristina C
core   +1 more source

Cryo-EM captures early intermediate steps in dynein activation by LIS1

Nature Communications
Cytoplasmic dynein-1 (dynein) is an essential molecular motor in eukaryotic cells. Dynein primarily exists in an autoinhibited Phi state and requires conformational changes to assemble with its cofactors and form active transport complexes.
Kendrick H. V. Nguyen, Eva P. Karasmanis, Agnieszka A. Kendrick, Samara L. Reck-Peterson, Andres E. Leschziner   +4 more
doaj   +1 more source

The Light Intermediate Chain 2 Subpopulation of Dynein Regulates Mitotic Spindle Orientation

Scientific Reports, 2016
Cytoplasmic dynein 1 is a multi-protein intracellular motor essential for mediating several mitotic functions, including the establishment of proper spindle orientation.
Sagar Mahale, Megha Kumar, Amit Sharma, Aswini Babu, Shashi Ranjan, Chetana Sachidanandan, Sivaram V. S. Mylavarapu   +6 more
doaj   +1 more source

SAV1 in Cooperation With FKBP52 Participates in Implantation

Advanced Science, EarlyView.
The MST‐SAV1 complex modulates FKBP52 phosphorylation to fine‐tune PR activity, ensuring timely uterine transition to receptivity under estrogen signaling for implantation. Stromal SAV1 scaffolds MST1/2‐mediated FKBP52 phosphorylation via noncanonical Hippo to promote PR activity.
Yuhan Shao, Yafang Lu, Zhaoyu Jia, Junxiang Ren, Ziyi Ge, Xinyu Liu, Hui Zhao, Zi‐Jiang Chen, Junhao Yan, Wei Wang, Jia Yuan   +10 more
wiley   +1 more source

Ipl1-dependent microtubule integrity and Bim1-dynein-mediated effective bias ensure timely MTOC clustering and nuclear migration.

, 2019
(A) Analysis of budded cells with an unsegregated nucleus in the wild-type CNVY108 and bim1Δ CNNV107 cells expressing histone H4-GFP. Bar, 5μm (left). The cells with nucleus remained unsegregated in the mother bud or at the neck in the bim1Δ cells with ...
Subhendu Som (6336227), Dibyendu Bhattacharyya (184588), Raja Paul (594399), Shreyas Sridhar (6336230), Kaustuv Sanyal (169834), Neha Varshney (6336224), Saptarshi Chatterjee (1750480)   +6 more
core   +1 more source

Differential effects of the dynein-regulatory factor Lissencephaly-1 on processive dynein-dynactin motility [PDF]

, 2017
Cytoplasmic dynein is the primary minus-end-directed microtubule motor protein in animal cells, performing a wide range of motile activities, including transport of vesicular cargos, mRNAs, viruses, and proteins.
Bryce E. Ackermann, McKenney, Richard J, Richard J. McKenney, Pedro A. Gutierrez, Gutierrez, Pedro A, Ackermann, Bryce E, Vershinin, Michael, Michael Vershinin   +7 more
core   +1 more source