New insights into the mechanism of dynein motor regulation by lissencephaly-1
eLife, 2020 Lissencephaly (‘smooth brain’) is a severe brain disease associated with numerous symptoms, including cognitive impairment, and shortened lifespan. The main causative gene of this disease – lissencephaly-1 (LIS1) – has been a focus of intense scrutiny ...
Steven M. Markus +2 more
semanticscholar +1 more source
Dynein and intraflagellar transport [PDF]
Experimental Cell Research, 2015 Publisher Summary This chapter provides a brief background on intraflagellar transport (IFT) and reviews the studies culminating in the identification of the dynein motor that powers retrograde IFT. IFT is the active movement of multi-subunit particles along axonemal doublet microtubules in the space between the outer-doublet microtubules and the ...
Hou, Yuqing, Witman, George B.
openaire +3 more sources
Visualization of dynein-dependent microtubule gliding at the cell cortex: implications for spindle positioning [PDF]
, 2011 Dynein motors move along the microtubule (MT) lattice in a processive “walking” manner. In the one-cell Caenorhabditis elegans embryo, dynein is required for spindle-pulling forces during mitosis.
Srayko, M., Gusnowski, E.M.
core +2 more sources
Investigating the role of R2TP-like co-chaperone complexes during axonemal dynein assembly [PDF]
, 2022 Motile cilia are specialised cell-types which in humans have important roles in the linings of the airways, the reproductive system and the brain.
Lennon, Jennifer
core +1 more source
Chemical Biology of Dynein [PDF]
, 2020 Cytoplasmic dynein is a AAA (ATPase Associated with various Activities) motor protein that transports cellular cargoes towards the microtubule minus-end.
Santarossa, Cristina C
core +2 more sources
Cortical dynein pulling mechanism is regulated by differentially targeted attachment molecule Num1
eLife, 2018 Cortical dynein generates pulling forces via microtubule (MT) end capture-shrinkage and lateral MT sliding mechanisms. In Saccharomyces cerevisiae, the dynein attachment molecule Num1 interacts with endoplasmic reticulum (ER) and mitochondria to ...
Safia Omer +2 more
doaj +1 more source
Dynein promotes sustained axonal growth and Schwann cell remodeling early during peripheral nerve regeneration. [PDF]
PLoS Genetics, 2019 Following injury, axons of the peripheral nervous system have retained the capacity for regeneration. While it is well established that injury signals require molecular motors for their transport from the injury site to the nucleus, whether kinesin and ...
Melissa Ducommun Priest +3 more
doaj +1 more source
Molecular mechanism of dynein-dynactin complex assembly by LIS1
ScienceCytoplasmic dynein is a microtubule motor vital for cellular organization and division. It functions as a ~4-megadalton complex containing its cofactor dynactin and a cargo-specific coiled-coil adaptor.
Kashish Singh +5 more
semanticscholar +1 more source
Dynein Harnesses Active Fluctuations of Microtubules for Faster Movement
Nature Physics, 2020 The cytoskeleton forms a dynamic network that generates fluctuations larger than thermal agitation of the cytoplasm1. Here, we tested whether dynein, a minus-end-directed microtubule (MT) motor2, can harness energy from these fluctuations using optical ...
Yasin Ezber +3 more
semanticscholar +1 more source
A novel role of centrin in flagellar motility: stabilizing an inner-arm dynein motor in the flagellar axoneme [PDF]
, 2014 Centrin is an evolutionarily conserved EF-hand calcium-binding protein found in the centriole of animals and the basal body of flagellated organisms. It was originally discovered in the flagellated unicellular green alga Chlamydomonas reinhardtii, where ...
Ziyin Li
core +1 more source