Results 81 to 90 of about 48,169 (274)

Pericentrosomal Redistribution of the Endoplasmic Reticulum Ensures Organelle Symmetric Inheritance and Mitotic Progression

Advanced Science, EarlyView.
Upon mitotic entry, RTN4 relocalizes to the pericentrosomal region, forming a more tubular ER network around centrosomes. CDK1‐mediated phosphorylation of RTN4 increases its interaction with Rab11 GTPase, facilitating dynein‐dependent transport of RTN4 to the pericentrosomal region.
Xiangyu Xu, Yalin Liu, Rongyi Wang, Wenwen Xu, Hao Shi, Ning Huang, Junlin Teng, Jin Meng, Pengli Zheng, Jianguo Chen   +9 more
wiley   +1 more source

Mechanical Properties of Inner-Arm Dynein-F (Dynein I1) Studied With In Vitro Motility Assays [PDF]

, 2007
Inner-arm dynein-f of Chlamydomonas flagella is a heterodimeric dynein. We performed conventional in vitro motility assays showing that dynein-f translocates microtubules at the comparatively low velocity of ∼1.2μm/s. From the dependence of velocity upon
Sakakibara, Hitoshi, Kojima, Hiroaki, Kotani, Norito, Burgess, Stan A., Oiwa, Kazuhiro   +4 more
core   +1 more source

A mouse neurodegenerative dynein heavy chain mutation alters dynein motility and localization in Neurospora crassa [PDF]

, 2012
Cytoplasmic dynein is responsible for the transport and delivery of cargoes in organisms ranging from humans to fungi. Dysfunction of dynein motor machinery due to mutations in dynein or its activating complex dynactin can result in one of several ...
King, Stephen J., Schnittker, Robert R., Plamann, Michael D., Nandini, Swaran, Sivagurunathan, Senthilkumar   +4 more
core   +3 more sources

Cryo-EM captures early intermediate steps in dynein activation by LIS1

Nature Communications
Cytoplasmic dynein-1 (dynein) is an essential molecular motor in eukaryotic cells. Dynein primarily exists in an autoinhibited Phi state and requires conformational changes to assemble with its cofactors and form active transport complexes.
Kendrick H. V. Nguyen, Eva P. Karasmanis, Agnieszka A. Kendrick, Samara L. Reck-Peterson, Andres E. Leschziner   +4 more
doaj   +1 more source

The Light Intermediate Chain 2 Subpopulation of Dynein Regulates Mitotic Spindle Orientation

Scientific Reports, 2016
Cytoplasmic dynein 1 is a multi-protein intracellular motor essential for mediating several mitotic functions, including the establishment of proper spindle orientation.
Sagar Mahale, Megha Kumar, Amit Sharma, Aswini Babu, Shashi Ranjan, Chetana Sachidanandan, Sivaram V. S. Mylavarapu   +6 more
doaj   +1 more source

Cargo adaptors regulate stepping and force generation of mammalian dynein-dynactin

Nature Chemical Biology, 2019
Cytoplasmic dynein is an ATP-driven motor that transports intracellular cargos along microtubules. Dynein adopts an inactive conformation when not attached to a cargo, and motility is activated when dynein assembles with dynactin and a cargo adaptor.
M. M. ElShenawy, J. Canty, Liya F. Oster, Luke S. Ferro, Zhou Zhou, S. Blanchard, A. Yildiz   +6 more
semanticscholar   +1 more source

The KIF6‐RBP Complex Orchestrates mRNA Transport Required for Sperm Flagellar Assembly

Advanced Science, EarlyView.
Two homozygous deleterious KIF6 variants are identified in unrelated men with impaired sperm motility. Mouse models and multi‐omics analyses reveal that KIF6 cooperates with the RNA‐binding proteins FMRP and FXR1 to deliver mRNAs essential for sperm flagellar assembly, linking disrupted mRNA transport to reduced abundance of key structural and ...
Chunbo Xie, Sibing Yi, Xinle Lin, Shen Zhang, Weili Wang, Shimin Yuan, Lanlan Meng, Yong Li, Chen Tan, Chunjia Wei, Yanyan Yu, Yaoqiong Liang, Huan Zhang, Liang Hu, Guangxiu Lu, Wenbin He, Qianjun Zhang, Juan Du, Ge Lin, Chaofeng Tu, Yue‐Qiu Tan   +20 more
wiley   +1 more source

Ciliobrevins as Tools for Studying Dynein Motor Function

Frontiers in Cellular Neuroscience, 2015
Dyneins are a small class of molecular motors that bind to microtubules and walk towards their minus ends. They are essential for the transport and distribution of organelles, signaling complexes and cytoskeletal elements.
Douglas eRoossien, Kyle eMiller, Gianluca eGallo   +2 more
doaj   +1 more source

LIS1 regulates cargo-adapter–mediated activation of dynein by overcoming its autoinhibition in vivo

Journal of Cell Biology, 2019
This study reveals the role of Lissencephaly-1 (LIS1) in cargo-adapter–mediated dynein activation. Furthermore, it discovers a role of LIS1 in switching dynein from an autoinhibited conformation to an open conformation that can be activated by dynactin ...
Rongde Qiu, Jun Zhang, Xin Xiang
semanticscholar   +1 more source

ATL2 Recruits TRAK1 to Promote Mitochondrial Transport at ER–Mitochondria Contact Sites

Advanced Science, EarlyView.
ABSTRACT Mitochondrial transport and distribution are crucial for cellular homeostasis, yet whether and how they are regulated by endoplasmic reticulum (ER)–mitochondria contact sites remains unclear. Here, we demonstrate that the ER protein atlastin‐2 (ATL2) orchestrates mitochondrial transport and distribution by promoting assembly of the transport ...
Yiru Cheng, Peiyuan Chai, Xiayuhe Pei, Yiwen Chen, Xiaoshuai Huang, Bei Liu, Yiqian Wu, Junlin Teng, Pengli Zheng, Jianguo Chen   +9 more
wiley   +1 more source