Results 81 to 90 of about 39,736 (248)
Targeted expression of truncated glued disrupts giant fiber synapse formation in Drosophila [PDF]
, 1999 Glued1 (Gl1) mutants produce a truncated protein that acts as a poison subunit and disables the cytoplasmic retrograde motor dynein. Heterozygous mutants have axonal defects in the adult eye and the nervous system.
Allen, Marcus J. +7 more
core
Slow Axonemal Dynein e Facilitates the Motility of Faster Dynein c [PDF]
, 2014 We highly purified the Chlamydomonas inner-arm dyneins e and c, considered to be single-headed subspecies. These two dyneins reside side-by-side along the peripheral doublet microtubules of the flagellum.
Sakakibara, Hitoshi +7 more
core +1 more source
Neuronal migration defects in the Loa dynein mutant mouse
Neural Development, 2011 Background Cytoplasmic dynein and its regulatory proteins have been implicated in neuronal and non-neuronal cell migration. A genetic model for analyzing the role of cytoplasmic dynein specifically in these processes has, however, been lacking.
Ori-McKenney Kassandra M +1 more
doaj +1 more source
New Insights Into the Three‐Dimensional Mechanics of the Flagellar Beat Cycle
Cytoskeleton, EarlyView.ABSTRACT Advances in imaging at the molecular scale have provided greater detail concerning the three‐dimensional structure of the ciliary/flagellar axoneme. Additionally, it has recently been confirmed that electrostatic forces regulate the dynein‐tubulin interaction at the microtubule binding domain (MTBD) of dynein, and at the junction of the nexin ...
Charles B. Lindemann
wiley +1 more source
Hyperactive KIF5A in Neurodegeneration
Cytoskeleton, EarlyView.ABSTRACT The highly polarised morphology of neurons and the sheer length of their axons make transport of cargoes throughout the cell a formidable task. Decades of evidence obtained from genetic studies on patients and animal models highlight deficits in axonal transport as a recurrent cause, or early contributing factor, in a plethora of ...
David Villarroel‐Campos +1 more
wiley +1 more source
Differential effects of the dynein-regulatory factor Lissencephaly-1 on processive dynein-dynactin motility [PDF]
, 2017 Cytoplasmic dynein is the primary minus-end-directed microtubule motor protein in animal cells, performing a wide range of motile activities, including transport of vesicular cargos, mRNAs, viruses, and proteins.
Bryce E. Ackermann +7 more
core +1 more source
Computational and Structural Biotechnology JournalCytoskeletal motor protein dynein belongs to the AAA+ superfamily of enzymes, functioning as a mechanochemical ATPase that converts chemical energy into force to drive its retrograde movements along microtubules.
Laleh Alisaraie +2 more
doaj +1 more source
NuMA recruits dynein activity to microtubule minus-ends at mitosis
eLife, 2017 To build the spindle at mitosis, motors exert spatially regulated forces on microtubules. We know that dynein pulls on mammalian spindle microtubule minus-ends, and this localized activity at ends is predicted to allow dynein to cluster microtubules into
Christina L Hueschen +3 more
doaj +1 more source
Journal of the Chinese Chemical Society, EarlyView.Model for how α‐syn modulates the positioning of endolysosomes in melanoma cells. (a) α‐syn tethers endolysosomes to the plasma membrane, a last step in anterograde transport. (b) Loss of α‐syn expression causes the loss of the tethering function, which leads to perinuclear vesicle clustering. Reproduced from the open access article.
Stephan N. Witt
wiley +1 more source
, 2014 Centrin is an evolutionarily conserved EF-hand calcium-binding protein found in the centriole of animals and the basal body of flagellated organisms. It was originally discovered in the flagellated unicellular green alga Chlamydomonas reinhardtii, where ...
Ziyin Li
core +1 more source