Results 101 to 110 of about 48,169 (274)
Cryo-EM of dynein microtubule-binding domains shows how an axonemal dynein distorts the microtubule
bioRxiv, 2019 Dyneins are motor proteins responsible for transport in the cytoplasm and the beating of the axoneme in cilia and flagella. They bind and release microtubules via a compact microtubule-binding domain (MTBD) at the end of a long coiled-coil stalk. Here we
S. Lacey +3 more
semanticscholar +1 more source
Cytoskeleton, EarlyView.ABSTRACT Cooperativity between cytoskeletal proteins is crucial for spatiotemporal coordination in biological processes, like oogenesis. In mammalian and Drosophila oogenesis, proper assembly and function of actin networks require coordination between actin assembly factors Spire and formins, as well as actin‐associated proteins like myosins and Rab ...
Joseph Y. Ong +7 more
wiley +1 more source
Cargo specificity, regulation, and therapeutic potential of cytoplasmic dynein
Experimental and Molecular MedicineIntracellular retrograde transport in eukaryotic cells relies exclusively on the molecular motor cytoplasmic dynein 1. Unlike its counterpart, kinesin, dynein has a single isoform, which raises questions about its cargo specificity and regulatory ...
Jin-Gyeong Park +6 more
doaj +1 more source
Dynein–Dynactin–NuMA clusters generate cortical spindle-pulling forces as a multi-arm ensemble
eLife, 2018 To position the mitotic spindle within the cell, dynamic plus ends of astral microtubules are pulled by membrane-associated cortical force-generating machinery.
Masako Okumura +3 more
semanticscholar +1 more source
C‐Terminal Tail Elongation Adds a New Dimension to the Tubulin Code
Cytoskeleton, EarlyView.ABSTRACT Tubulin C‐terminal tails undergo diverse post‐translational modifications that regulate microtubule interactions with motors and severing enzymes. TTLL11, a member of the tubulin tyrosine ligase‐like (TTLL) family, uniquely catalyzes glutamate addition to the terminal α‐carboxyl group of both α‐ and β‐primary tubulin tails.
Jana Campbell, Cyril Barinka
wiley +1 more source
Dynein and Intraflagellar Transport [PDF]
, 2013 This chapter provides a brief background on intraflagellar transport (IFT) and reviews the studies culminating in the identification of the dynein motor that powers retrograde IFT.
Witman, George B.
core +1 more source
CRACR2a is a calcium-activated dynein adaptor protein that regulates endocytic traffic
Journal of Cell Biology, 2019 Cytoplasmic dynein is a minus end–directed microtubule motor that transports intracellular cargoes. Transport is initiated by coiled-coil adaptors that (a) join dynein and its cofactor dynactin into a motile complex and (b) interact with a cargo-bound ...
Yuxiao Wang +5 more
semanticscholar +1 more source
Journal of the Chinese Chemical Society, EarlyView.Model for how α‐syn modulates the positioning of endolysosomes in melanoma cells. (a) α‐syn tethers endolysosomes to the plasma membrane, a last step in anterograde transport. (b) Loss of α‐syn expression causes the loss of the tethering function, which leads to perinuclear vesicle clustering. Reproduced from the open access article.
Stephan N. Witt
wiley +1 more source
Dyneins Motor on in Plants [PDF]
Traffic, 2002 A recent report based on analysis of the Arabidopsis genome suggested that angiosperms do not contain the dynein microtubule motor. However, examination of the whole genome shotgun sequence for rice (Oryza sativa) has revealed that four dynein heavy chains are present in this monocot, indicating that the apparent lack of these sequences in Arabidopsis
openaire +2 more sources
Recombinant human cytoplasmic dynein heavy chain 1 and 2: Observation of dynein-2 motor activity in vitro [PDF]
, 2011 Cytoplasmic dynein is a microtubule (MT) motor protein comprising two classes: dynein-1 and dynein-2. We purified recombinant human dynein-1 and dynein-2 from HEK-293 cells by expressing the streptavidin-binding peptide-tagged human cytoplasmic dynein-1 ...
Murayama, Takashi +7 more
core +1 more source