Results 121 to 130 of about 48,169 (274)

Regulation of Cytoplasmic Dynein ATPase by Lis1 [PDF]

, 2006
Mutations in Lis1 cause classical lissencephaly, a developmental brain abnormality characterized by defects in neuronal positioning.Over the last decade, a clear link has been forged between Lis1 and the microtubule motor cytoplasmic dynein.
Lanier, Lorene, Musacchio, Andrea, King, Stephen J., Smith, Deanna S., Tarricone, Cataldo, Guillotte, Aimee, Hebbar, Sachin, Schmitt, E. William, Mesngon, Mariano T.   +8 more
core   +2 more sources

Dynein’s directionality is controlled by the angle and length of its stalk

Nature, 2019
The ability of cytoskeletal motors to move unidirectionally along filamentous tracks is central to their role in cargo transport, motility and cell division.
Sinan Can, S. Lacey, Mert Gur, A. Carter, A. Yildiz   +4 more
semanticscholar   +1 more source

Sperm Mitochondrial DNA Copy Number and Nuclear DNA Methylation Across Clinical and Non‐Clinical Preconception Cohorts

Andrology, EarlyView.
ABSTRACT Background Sperm mitochondrial DNA copy number is an emerging marker of male fertility, with elevated mtDNAcn associated with poor semen quality across various populations. Sperm DNA methylation has also been previously demonstrated to be negatively correlated with semen parameters in IVF cohorts.
Savni Sawant, Karolina Nowak, Amanda L. Paskavitz, Emily Houle, Ricardo P. Bertolla, Lidia Minguez‐Alarcon, Russ Hauser, J. Richard Pilsner   +7 more
wiley   +1 more source

Targeted expression of truncated glued disrupts giant fiber synapse formation in Drosophila [PDF]

, 1999
Glued1 (Gl1) mutants produce a truncated protein that acts as a poison subunit and disables the cytoplasmic retrograde motor dynein. Heterozygous mutants have axonal defects in the adult eye and the nervous system.
Allen, Marcus J., Murphey, R. K., Shan, Xiaoliang, Moffat, Kevin G., Allen, Marcus James, Froggett, Stephan J., Caruccio, Phyllis, Murphey, R.K.   +7 more
core  

Application of temperature replica exchange molecular dynamics: Structure of mitotic spindle-associated protein SHE1 and its binding to dynein

Computational and Structural Biotechnology Journal
Cytoskeletal motor protein dynein belongs to the AAA+ superfamily of enzymes, functioning as a mechanochemical ATPase that converts chemical energy into force to drive its retrograde movements along microtubules.
Laleh Alisaraie, Oliver Stueker, Sayi’Mone Tati   +2 more
doaj   +1 more source

HIV-1 Engages a Dynein-Dynactin-BICD2 Complex for Infection and Transport to the Nucleus

Journal of Virology, 2018
During HIV-1 infection, the virus must travel across the cytoplasm to enter the nucleus. The host cell motor protein complex dynein has been implicated in HIV-1 intracellular transport. We show that expression of the dynein heavy chain, components of the
Stephanie K. Carnes, Jing-jiao Zhou, C. Aiken   +2 more
semanticscholar   +1 more source

Lewy bodies are surrounded by granulovacuolar degeneration bodies in dementia with Lewy bodies

Brain Pathology, EarlyView.
Here, we report Lewy bodies (LBs) to be enriched for tau‐laden granulovacuolar degeneration bodies (GVBs), suggesting a potential mechanistic interface between α‐synuclein and tau pathology in dementia with Lewy bodies (DLB). Abstract Lewy bodies (LBs), composed primarily of aggregated α‐synuclein (α‐syn), are the pathological hallmark of Lewy body ...
Searlait Thom, Pawel Palmowski, Andrew Porter, Joe O'Neill, Johannes Attems, Laura A. Smith, Viktor I. Korolchuk, Daniel Erskine   +7 more
wiley   +1 more source

Cytoplasmic dynein and early endosome transport [PDF]

, 2015
Microtubule-based distribution of organelles/vesicles is crucial for the function of many types of eukaryotic cells and the molecular motor cytoplasmic dynein is required for transporting a variety of cellular cargos toward the microtubule minus ends ...
Xiang, X, Yao, X, Qiu, R, Arst, HN, Pealva, MA, Zhang, J   +5 more
core   +1 more source

Dynein activator Hook1 is required for trafficking of BDNF-signaling endosomes in neurons

Journal of Cell Biology, 2018
&NA; Axonal transport is required for neuronal development and survival. Transport from the axon to the soma is driven by the molecular motor cytoplasmic dynein, yet it remains unclear how dynein is spatially and temporally regulated.
Mara A Olenick, R. Dominguez, E. Holzbaur   +2 more
semanticscholar   +1 more source

Inhibition of leucine‐rich kinase 2 (LRRK2) promotes peripheral axon regeneration via phosphorylation‐network remodelling

British Journal of Pharmacology, EarlyView.
Background and Purpose In contrast to neurons in the central nervous system, neurons in the peripheral nervous system can regenerate axons after injury via activation of a pro‐regenerative transcriptional programme. Pathogenic mutations in leucine‐rich repeat kinase 2 (LRRK2) are the most common genetic cause of Parkinson's disease, and several small ...
Eun‐Hae Jang, Eun Mo Yang, Gil Song, Seung Min Park, Harryn Choi, Jaeyong Kim, Chanil Kim, Yunho Gim, Hyuk‐Joo Jeon, Yewon Cho, Jong Bae Park, Eun‐Mi Hur   +11 more
wiley   +1 more source