Results 131 to 140 of about 37,129 (243)

Cilia in Nervous System Development, Function, and Disease

MedComm – Future Medicine, Volume 5, Issue 2, June 2026.
Cilia are evolutionarily conserved organelles that function as essential sensory and motility platforms in the nervous system. This review outlines key cilia‐dependent signaling pathways and their roles in neural development and function. Furthermore, it highlights how ciliary dysfunction can lead to a variety of neurological disorders, known as ...
Qingchao Li, Anqi Zhang, Ting Song
wiley   +1 more source

Chapter 4 Probing the Force Generation and Stepping Behavior

, 2014
Cytoplasmic dynein, which is the largest and arguably the most complex cytoskeletal motor protein, plays fundamental roles during cell division, nuclear positioning, and organelle and mRNA transport, by generating force and movement toward the minus ends
Of Cytoplasmic Dynein, Arne Gennerich, Samara L. Reck-peterson   +2 more
core  

The BICD2 dynein cargo adaptor binds to the HPV16 L2 capsid protein and promotes HPV infection.

PLoS Pathogens
During entry, human papillomavirus (HPV) traffics from the endosome to the trans Golgi network (TGN) and Golgi and then the nucleus to cause infection. Although dynein is thought to play a role in HPV infection, how this host motor recruits the virus to ...
Kaitlyn Speckhart, Jeongjoon Choi, Daniel DiMaio, Billy Tsai   +3 more
doaj   +1 more source

Physicochemical Properties and Mechanisms of Oil‐In‐Water Emulsion Formation and Stabilization by Yeast Protein Ingredients From Saccharomyces cerevisiae and Candida utilis

Sustainable Food Proteins, Volume 4, Issue 2, June 2026.
Emulsion formation is associated with the soluble phase, while the presence of yeast cells enhances stability through a steric mechanism, with a protein‐to‐oil ratio greater than 1:10 required to prevent oil droplet coalescence. ABSTRACT This study explored the nutrient composition, protein profile, physicochemical and emulsifying properties of ...
Luca Amagliani, Nicola Cesario Angelino, Claudine Bovay, Charlotte Gancel, Fikrey Andetsion, Michael Affolter, Carine Morgenegg, Biljana Bogicevic, Giulia Marchesini   +8 more
wiley   +1 more source

The Mechanism of NLRP3 Inflammasome Activation and Its Roles in Chronic Rhinosinusitis

World Journal of Otorhinolaryngology - Head and Neck Surgery, Volume 12, Issue 3, Page 362-373, June 2026.
ABSTRACT NLRP3 (NLR family pyrin domain containing 3) is one of the crucial receptors in pathogen recognition receptor (PRR) families which can recognize the pathogen‐associated molecular patterns (PAMPs) and the damage‐associated molecular patterns (DAMPs), thus triggering innate immune response. After NLRP3 activation, it recruits the adaptor protein
Dong‐Lin Li, Yue Li, Yan‐Jie Jiang, Ge‐Hua Zhang, Li‐Hong Chang   +4 more
wiley   +1 more source

Investigating the regulators of cytoplasmic dynein [PDF]

, 2019
2019 Fall.Includes bibliographical references.Organization of the cell is a dynamic and complex process that is often underappreciated. To accomplish this, cells use motor proteins to move different cargo to their destination.
Dilsaver, Matthew, author, Argueso, Juan Lucas, committee member, Markus, Steven, advisor, Di Pietro, Santiago, committee member, DeLuca, Jennifer, committee member   +4 more
core  

Effects of Lysine Deacetylation Inhibition Alone or in Combination With Arimoclomol on TDP‐43 Proteinopathy

Journal of Neurochemistry, Volume 170, Issue 6, June 2026.
TDP‐43 pathology is a hallmark of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia. Peptidyl‐prolyl cis–trans isomerase A (PPIA), a foldase and chaperone protein, modulates TDP‐43 function in an acetylation‐dependent manner. Here, we show that inhibition of lysine deacetylation with vorinostat (SAHA) increases PPIA acetylation and ...
Serena Scozzari, Stefano Fabrizio Columbro, Monica Favagrossa, Massimo Tortarolo, Alfredo Cagnotto, Mario Salmona, Giovanni De Marco, Caterina Bendotti, Andrea Calvo, Laura Pasetto, Valentina Bonetto   +10 more
wiley   +1 more source

Regulation of the Cytoplasmic Dynein Motor [PDF]

, 2009
The large size and complex organization of eukaryotic cells necessitates active, directional transport for efficient relocalization of cellular components and fidelity in their placement.
Kardon, Julia Ruth
core  

Force-Induced Bidirectional Stepping of Cytoplasmic Dynein

, 2007
SummaryCytoplasmic dynein is a minus-end-directed microtubule motor whose mechanism of movement remains poorly understood. Here, we use optical tweezers to examine the force-dependent stepping behavior of yeast cytoplasmic dynein.
Vale, Ronald D., Reck-Peterson, Samara L., Arne Gennerich, Ronald D. Vale, Samara L. Reck-Peterson, Carter, Andrew P., Andrew P. Carter, Gennerich, Arne   +7 more
core   +1 more source

Mechanisms of Regulation of Cytoplasmic Dynein

, 2019
Cytoplasmic dynein-1 (dynein) is a microtubule-based motor protein that is essential for maintaining proper spatial and temporal organization of the cellular interior during both interphase and cell division.
Htet, Zaw Min
core