Results 131 to 140 of about 48,169 (274)
Cold Spring Harbor Perspectives in Biology, 2016 Axonemal dyneins form the inner and outer rows of arms associated with the doublet microtubules of motile cilia. These enzymes convert the chemical energy released from adenosine triphosphate (ATP) hydrolysis into mechanical work by causing the doublets to slide with respect to each other.
openaire +2 more sources
Dynarrestin, a Novel Inhibitor of Cytoplasmic Dynein
Cell Chemical Biology, 2018 SUMMARY Aberrant hedgehog (Hh) signaling contributes to the pathogenesis of multiple cancers. Available inhibitors target Smoothened (Smo), which can acquire mutations causing drug resistance.
S. Höing +25 more
semanticscholar +1 more source
Clinical Genetics, EarlyView.We describe a previously unreported phenotype related to postzygotic ACTB variants with hypomelanosis of Ito, characterized by hypopigmentation associated or not with neurodevelopmental features, distinct from Becker presentations, bridging constitutional neurodevelopmental and somatic cutaneous phenotypes.
Estella Castillon +9 more
wiley +1 more source
Reconstitution of dynein transport to the microtubule plus end by kinesin
eLife, 2014 Cytoplasmic dynein powers intracellular movement of cargo toward the microtubule minus end. The first step in a variety of dynein transport events is the targeting of dynein to the dynamic microtubule plus end, but the molecular mechanism underlying this
Anthony J Roberts +2 more
doaj +1 more source
RNA-directed activation of cytoplasmic dynein-1 in reconstituted transport RNPs
bioRxiv, 2018 Polarised mRNA transport is a prevalent mechanism for spatial control of protein synthesis. However, the composition of transported ribonucleoprotein particles (RNPs) and the regulation of their movement are poorly understood.
M. McClintock +6 more
semanticscholar +1 more source
Huntingtin as an Actin Organizer: Structural and Functional Insights
Cytoskeleton, EarlyView.
M. Capizzi, S. Humbert
wiley +1 more source
Clinical Genetics, EarlyView.This study reports a female proband with a de novo 9q34.11 deletion affecting SET, who underwent a 28‐year diagnostic odyssey after an atypical Rett syndrome clinical diagnosis. Genomic and proteomics analyses confirmed SET haploinsufficiency, refining the critical 9q34.11 region, and supporting speech therapy benefits in improving meaningful ...
Angelo Condell +14 more
wiley +1 more source
Dynein isoforms in paramecium [PDF]
, 1993 Dynein is an ATPase that powers the translocation of molecules along microtubules. This microtubule motor molecule was first discovered in cilia where it powers ciliary beating.
Beckwith, Susan Marie
core
Clinical Genetics, EarlyView.A homozygous truncating variant in LRGUK results in loss of the LRGUK protein and causes multiple morphological abnormalities of the flagella (MMAF), disrupted axonemal architecture, central pair defects, abnormal chromatin organization, and severe male infertility, establishing LRGUK as a novel human infertility gene.
Wiâme Mokkedem +14 more
wiley +1 more source
Apoptotic cleavage of cytoplasmic dynein intermediate chain and p150Glued stops dynein-dependent membrane motility [PDF]
, 2001 Cytoplasmic dynein is the major minus end-directed microtubule motor in animal cells, and associates with many of its cargoes in conjunction with the dynactin complex.
Lane, Jon D. +7 more
core +1 more source