Results 131 to 140 of about 60,261 (241)
Opening closed inward rectifier potassium channel doors
British Journal of Pharmacology, Volume 183, Issue 10, Page 2197-2218, May 2026.Inwardly rectifying potassium (KIR) channels are essential regulators of membrane potential in excitable and non‐excitable tissues. Although KIR channels exhibit a biophysical preference for potassium influx due to voltage‐dependent block of outward current by polyamines and Mg2+, under physiological conditions, they predominantly mediate K+ efflux ...
Anna Stary‐Weinzinger +3 more
wiley +1 more source
Mitochondrial Transfer in the Tumor Microenvironment
Cancer Science, Volume 117, Issue 5, Page 1189-1198, May 2026.Mitochondria are actively exchanged among tumor, immune, stromal, and neuronal cells within the tumor microenvironment. Such transfer rewires tumor metabolism, promotes immune evasion, and drives therapy resistance. Targeting mitochondrial transfer or harnessing mitochondrial transplantation represents a promising strategy to restore antitumor immunity
Ryo Omae +2 more
wiley +1 more source
Clinical Genetics, Volume 109, Issue 5, Page 937-945, May 2026.CT scan image of a 17‐year‐old female with primary ciliary dyskinesia (PCD) showing dextrocardia and bilateral bronchiectasis. The study describes genetic mutations affecting patients with PCD in Qatar and the corresponding clinical phenotype of affected patients.
Atqah AbdulWahab +7 more
wiley +1 more source
The BICD2 dynein cargo adaptor binds to the HPV16 L2 capsid protein and promotes HPV infection.
PLoS PathogensDuring entry, human papillomavirus (HPV) traffics from the endosome to the trans Golgi network (TGN) and Golgi and then the nucleus to cause infection. Although dynein is thought to play a role in HPV infection, how this host motor recruits the virus to ...
Kaitlyn Speckhart +3 more
doaj +1 more source
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2000 Dyneins are large multi-component microtubule-based molecular motors involved in many fundamental cellular processes including vesicular transport, mitosis and ciliary/flagellar beating. In order to achieve useful work, these enzymes must contain motor, cargo-binding and regulatory components. The ATPase and microtubule motor domains are located within
openaire +2 more sources
Radial Spokes-A Snapshot of the Motility Regulation, Assembly, and Evolution of Cilia and Flagella [PDF]
, 2016 Propulsive forces generated by cilia and flagella are used in events that are critical for the thriving of diverse eukaryotic organisms in their environments. Despite distinctive strokes and regulations, the majority of them adopt the 9+2 axoneme that is
Liu, Yi, Yang, Pinfen, Zhu, Xiaoyan
core +1 more source
General and Specific Promotion of Flagellar Assembly by a Flagellar Nucleoside Diphosphate Kinase [PDF]
, 2017 Nucleoside diphosphate kinases (NDKs) play a central role in diverse cellular processes using the canonical NDK activity or alternative mechanisms that remain poorly defined.
Ciruelas, Kristine S. +9 more
core +1 more source
PACS1 syndrome mutation disrupts dynein-mediated cargo transport via HDAC6 and BICD2. [PDF]
Commun BiolYang Y +11 more
europepmc +1 more source
The Rab5 effector Rabankyrin-5 mediates endosomal fusion and trafficking of human papillomavirus during early entry. [PDF]
Proc Natl Acad Sci U S ALove M, Dang RC, Xie J, Zhang P.
europepmc +1 more source
Impaired dynein function preserves spinal interneuron survival and positioning in an ALS-like mouse model. [PDF]
PLoS OneChristoforidou E +6 more
europepmc +1 more source