Results 151 to 160 of about 48,169 (274)
Cytoplasmic dynein crosslinks and slides anti-parallel microtubules using its two motor domains
eLife, 2013 Cytoplasmic dynein is the predominant minus-end-directed microtubule (MT) motor in most eukaryotic cells. In addition to transporting vesicular cargos, dynein helps to organize MTs within MT networks such as mitotic spindles. How dynein performs such non-
Marvin E Tanenbaum +2 more
doaj +1 more source
Tau directs intracellular trafficking by regulating the forces exerted by kinesin and dynein teams
bioRxiv, 2017 Organelles, proteins, and mRNA are transported bidirectionally along microtubules by plus-end directed kinesin and minus-end directed dynein motors.
Abdullah R. Chaudhary +3 more
semanticscholar +1 more source
Mitochondrial control of ciliary gene expression and structure in striatal neurons
The Journal of Physiology, EarlyView.Abstract figure legend Neurons drive animal behaviour by receiving and transmitting information and require energy, primarily supplied by mitochondria, to function. Additionally, neurons need to sense environmental changes to adapt, a function that is locally played by the primary cilia.
Dogukan H. Ulgen +5 more
wiley +1 more source
Biology Open, 2013 Summary We previously reported that the small nuclear RNA processing complex, Integrator, is required for dynein recruitment to the nuclear envelope at mitotic onset in cultured human cells.
Jeanne N. Jodoin +6 more
doaj +1 more source
Nature Structural &Molecular Biology, 2017 Cilia are multifunctional organelles that are constructed using intraflagellar transport (IFT) of cargo to and from their tip. It is widely held that the retrograde IFT motor, dynein-2, must be controlled in order to reach the ciliary tip and then ...
Katerina Toropova +2 more
semanticscholar +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend Schematic outlining the activation of hypoxia‐sensitive pathways, the influence of hypoxia and associated pathways on the cytoskeleton, and the impact of these on disease progression. Abstract A highly‐regulated and dynamic cytoskeleton is vital for functional cellular physiology and the maintenance of homeostasis.
Darragh Flood, Cormac T. Taylor
wiley +1 more source
Dynein Clusters into Lipid Microdomains on Phagosomes to Drive Rapid Transport toward Lysosomes
Cell, 2016 Summary Diverse cellular processes are driven by motor proteins that are recruited to and generate force on lipid membranes. Surprisingly little is known about how membranes control the force from motors and how this may impact specific cellular ...
Ashim Rai +5 more
semanticscholar +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend Regulatory mechanisms such as alternative splicing, post‐translational modification, membrane trafficking, and protein interactions control channel gating, membrane abundance, and overall activity of PIEZO2. Proper regulation supports PIEZO2‐dependent proprioceptive, somatosensory, nociceptive, pruriceptive and interoceptive ...
Eunice I. Oribamise +2 more
wiley +1 more source
Dynein mutagenesis reveals the molecular basis for dynein regulation in broad spectrum neurological diseases [PDF]
, 2020 2020 Spring.Includes bibliographical references.Eukaryotic cells rely on cytoskeletal networks to organize materials, transport organelles, give cells shape, and provide locomotion.
Bamburg, James R., committee member +4 more
core
Force-Induced Bidirectional Stepping of Cytoplasmic Dynein [PDF]
, 2007 SummaryCytoplasmic dynein is a minus-end-directed microtubule motor whose mechanism of movement remains poorly understood. Here, we use optical tweezers to examine the force-dependent stepping behavior of yeast cytoplasmic dynein.
Vale, Ronald D. +7 more
core +1 more source