Results 141 to 150 of about 48,169 (274)

The XMAP215-family protein DdCP224 is required for cortical interactions of microtubules

BMC Cell Biology, 2004
Background Interactions of peripheral microtubule tips with the cell cortex are of crucial importance for nuclear migration, spindle orientation, centrosome positioning and directional cell movement.
Hestermann Andrea, Gräf Ralph
doaj   +1 more source

RNF13 regulates the endolysosomal pathway through interaction with the small GTPase Arl8B

The FEBS Journal, EarlyView.
The E3 ubiquitin ligase RNF13 functions as a regulatory scaffold, organizing Arl8B‐dependent complexes and tuning downstream signaling that controls endolysosomal organization and trafficking. In this model, wild‐type RNF13 associates with Arl8B on endolysosomes, whereas Arl8B (E22D/F55A) or RNF13 (L244A) variants weaken complex assembly, potentially ...
Audrey M. Sénécal, Valérie C. Cabana, Antoine Y. Bouchard, Laurent Cappadocia, Marc P. Lussier   +4 more
wiley   +1 more source

Chapter 4 Probing the Force Generation and Stepping Behavior [PDF]

, 2014
Cytoplasmic dynein, which is the largest and arguably the most complex cytoskeletal motor protein, plays fundamental roles during cell division, nuclear positioning, and organelle and mRNA transport, by generating force and movement toward the minus ends
Of Cytoplasmic Dynein, Arne Gennerich, Samara L. Reck-peterson   +2 more
core  

Roles of dynein and dynactin in early endosome dynamics revealed using automated tracking and global analysis.

PLoS ONE, 2011
Microtubule-dependent movement is crucial for the spatial organization of endosomes in most eukaryotes, but as yet there has been no systematic analysis of how a particular microtubule motor contributes to early endosome dynamics.
Neftali Flores-Rodriguez, Salman S Rogers, David A Kenwright, Thomas A Waigh, Philip G Woodman, Victoria J Allan   +5 more
doaj   +1 more source

Reconstruction of native cellular microanatomy in a novel bioengineered full thickness human nasal mucosal construct

Journal of Anatomy, EarlyView.
Bioengineered tissue constructs are vital technologies employed in in vitro testing of both fundamental biological principles and industrial screening practices. Current approaches to modelling the nasal mucosa in vitro are not representative and are associated with limitations that impact their reliability and predictive value.
Steven Bradbury, Bethany Dickson, Nicola Curtis, David Bunton, Kirsty Goncalves, Stefan Przyborski   +5 more
wiley   +1 more source

Dynein light chain 1 and a spindle-associated adaptor promote dynein asymmetry and spindle orientation. [PDF]

, 2012
The cytoplasmic dynein motor generates pulling forces to center and orient the mitotic spindle within the cell. During this positioning process, dynein oscillates from one pole of the cell cortex to the other but only accumulates at the pole farthest ...
Francis A. Barr, Barr, FA, Anja K. Dunsch, Hammond, D, Lloyd, J, Lothar Schermelleh, Schermelleh, L, Gruneberg, Ulrike, Dunsch, AK, Barr, Francis, Gruneberg, U, Ulrike Gruneberg, Jennifer Lloyd, Dean Hammond   +13 more
core   +1 more source

Integrative Phosphoproteomic Profiling Reveals Stage‐Specific Signalling and Metabolism in Equine Melanocytic Neoplasm

Veterinary and Comparative Oncology, EarlyView.
ABSTRACT Equine melanocytic neoplasms (EMN) are aggressive tumours characterised by high metastatic potential and limited therapeutic options available. However, the molecular mechanisms underlying their progression remain poorly understood. This study therefore presents the integrative phosphoproteomic analysis of EMN tissue, with the aim of ...
Paitoon Srimontri, Amornthep Kingkaw, Nawarus Prapaiwan, Rangsima Sujittosakul, Nichapat Iamkaewprasert, Jiraschaya Piputwat, Puetta Isama‐al, Thanutchanok Munkongdee, Thanapon Chotikaprakal, Petchpailin Yanyongsirikarn, Narumon Phaonakrop, Sittiruk Roytrakul, Wanwipa Vongsangnak, Parichart Tesena   +13 more
wiley   +1 more source

Spaceborne and spaceborn: Physiological aspects of pregnancy and birth during interplanetary flight

Experimental Physiology, EarlyView.
Abstract Crewed interplanetary return missions that are on the planning horizon will take years, more than enough time for initiation and completion of a pregnancy. Pregnancy is viewed as a sequence of processes – fertilization, blastocyst formation, implantation, gastrulation, placentation, organogenesis, gross morphogenesis, birth and neonatal ...
Arun V. Holden
wiley   +1 more source

The dynein microtubule motor

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2000
Dyneins are large multi-component microtubule-based molecular motors involved in many fundamental cellular processes including vesicular transport, mitosis and ciliary/flagellar beating. In order to achieve useful work, these enzymes must contain motor, cargo-binding and regulatory components. The ATPase and microtubule motor domains are located within
openaire   +2 more sources

Combined exome and whole-genome sequencing identifies mutations in ARMC4 as a cause of primary ciliary dyskinesia with defects in the outer dynein arm. [PDF]

, 2013
Primary ciliary dyskinesia (PCD) is a rare, genetically heterogeneous ciliopathy disorder affecting cilia and sperm motility. A range of ultrastructural defects of the axoneme underlie the disease, which is characterised by chronic respiratory symptoms ...
Danke-Roelse, JE, Hart, S.L., Munye, Mustafa M., Scambler, PJ, Rosser, E.M., Hart, Stephen L, Beales, Philip L, Bacchelli, C, Moore, Anthony T., Chung, Eddie MK, Sloper, John J, Danke-Roelse, Jeannette E, Moore, A.T., Pals, Gerard, Beales, Philip L., Sloper, John J., Moore, Anthony T, Hogg, C, Hogg, C., Bacchelli, Chiara, Mitchison, Hannah M, Shoemark, A., Moore, AT, James, C.T., Scambler, Peter J, Chung, E.M.K., Rosser, Elisabeth M., Bacchelli, C., Shoemark, Amelia; id_orcid, Patel, M., Hogg, Claire, Onoufriadis, Alexandros, Schmidts, Miriam, Emes, R.D., Munye, Mustafa M, Hull, S., Sloper, JJ, Hull, Sarah, Beales, PL, Beales, P.L., Hart, Stephen L., Munye, MM, Schmidts, M, James, Chela T, Scambler, P.J., James, Chela T., Mitchison, H.M., nke-Roelse, J.E., Hull, S, Onoufriadis, A., Rosser, Elisabeth M, Emes, Richard D., Patel, Mitali, Pals, G., Mitchison, Hannah M., Patel, M, Pals, G, Emes, RD, Munye, M.M., James, CT, Schmidts, M., Danke-Roelse, Jeannette E., Chung, Eddie M.K., Shoemark, Amelia, Mitchison, HM, Emes, Richard D, Chung, EM, Shoemark, A, Onoufriadis, A, Sloper, J.J., Hart, SL, Rosser, EM, Scambler, Peter J.   +72 more
core   +1 more source