Results 1 to 10 of about 2,689 (122)

Nde1 promotes Lis1-mediated activation of dynein [PDF]

Nature Communications, 2023
Cytoplasmic dynein drives the motility and force generation functions towards the microtubule minus end. The assembly of dynein with dynactin and a cargo adaptor in an active transport complex is facilitated by Lis1 and Nde1/Ndel1.
Yuanchang Zhao, Sena Oten, Ahmet Yildiz
doaj   +2 more sources

LIS1 mediated Schwann cell reprogramming enhances perineural invasion by activating the serine/NMDAR/AKT signaling pathway in head and neck squamous carcinoma [PDF]

Cancer Cell International
Background Perineural invasion (PNI) has significant implications for the prognosis of patients with head and neck squamous cell carcinoma (HNSCC).
Jing Liu, Ao Dai, Yiding Liu, Yuying Zhang, Bing Yan, Dong Jin, Fu Wang, Lu Gao   +7 more
doaj   +2 more sources

Cryo-EM captures early intermediate steps in dynein activation by LIS1 [PDF]

Nature Communications
Cytoplasmic dynein-1 (dynein) is an essential molecular motor in eukaryotic cells. Dynein primarily exists in an autoinhibited Phi state and requires conformational changes to assemble with its cofactors and form active transport complexes.
Kendrick H. V. Nguyen, Eva P. Karasmanis, Agnieszka A. Kendrick, Samara L. Reck-Peterson, Andres E. Leschziner   +4 more
doaj   +2 more sources

Cancer Stem Cells Shift Metabolite Acetyl-Coenzyme A to Abrogate the Differentiation of CD103⁺ T Cells. [PDF]

Adv Sci (Weinh)
Lei et al. demonstrate that cancer stem cells (CSCs) play a pivotal role in impairing the differentiation of CD103+ T cells in patients with non‐small‐cell lung cancer. The key mechanism involves CSC‐derived acetyl‐CoA, which disrupts CD103+ T cell differentiation by sequentially inducing acetylation and ubiquitination of the Blimp‐1 protein. Targeting
Lei J, Ji H, Guo J, Liu M, Su D, Zheng Y, Xu L, Cao Q, Ren T, Gui J, Wen Z.   +10 more
europepmc   +2 more sources

Interneuron Heterotopia in the Lis1 Mutant Mouse Cortex Underlies a Structural and Functional Schizophrenia-Like Phenotype

Frontiers in Cell and Developmental Biology, 2021
LIS1 is one of the principal genes related to Type I lissencephaly, a severe human brain malformation characterized by an abnormal neuronal migration in the cortex during embryonic development.
Emilio Geijo-Barrientos, Salvador Martinez, Alicia Estirado   +2 more
exaly   +3 more sources

Pt-LIS1 participates nuclear deformation and acrosome formation via regulating Dynein-1 during spermatogenesis in Portunus trituberculatus [PDF]

Scientific Reports
Spermatogenesis involves complex dynamic mechanisms. Dynein-1 is a key carrier in cellular cargo transport, participating in nuclear deformation and acrosome formation during spermatogenesis.
Le Chang, Qiu Meng Xiang, Zai-Tian Liao, Jun-Quan Zhu, Chang-Kao Mu, Chun-Lin Wang, Cong-Cong Hou   +6 more
doaj   +2 more sources

The LIS1/NDE1 Complex Is Essential for FGF Signaling by Regulating FGF Receptor Intracellular Trafficking

Cell Reports, 2018
Summary: Intracellular transport of membranous organelles and protein complexes to various destinations is fundamental to signaling transduction and cellular function.
Xiaoling Li, Hai Song, Nan Tang
exaly   +3 more sources

Gene-specific long-term course, neurodevelopmental outcome and quality of life in patients with LIS1/PAFAH1B1-, DCX-, DYNC1H1-, TUBA1A- and TUBG1-related lissencephaly [PDF]

Orphanet Journal of Rare Diseases
Background Classic lissencephaly is a malformation of cortical development that includes agyria and pachygyria. The major clinical symptoms are developmental impairment, muscular hypotonia, and drug-resistant epilepsy.
Christiane R. Proepper, Lisa-Maria Schwarz, Sofia M. Schuetz, Katja von Au, Thomas Bast, Nathalie Beaud, Ingo Borggraefe, Friedrich Bosch, Melanie Busse, Jena Chung, Otfried Debus, Katharina Diepold, Thomas Fries, Gero von Gersdorff, Martin Haeussler, Andreas Hahn, Till Hartlieb, Ralf Heiming, Peter Herkenrath, Gerhard Kluger, Jonas H. Kreth, Gerhard Kurlemann, Peter Moeller, Deborah J. Morris-Rosendahl, Axel Panzer, Heike Philippi, Sophia Ruegner, Carolina Toepfer, Silvia Vieker, Adelheid Wiemer-Kruel, Anika Winter, Gerhard Schuierer, Ute Hehr, Tobias Geis   +33 more
doaj   +2 more sources

Capturing disease severity in LIS1-lissencephaly reveals proteostasis dysregulation in patient-derived forebrain organoids [PDF]

Nature Communications
LIS1-lissencephaly is a neurodevelopmental disorder marked by reduced cortical folding and severe neurological impairment. Although all cases result from heterozygous mutations in the LIS1 gene, patients present a broad spectrum of severity. Here, we use
Lea Zillich, Matteo Gasparotto, Andrea Carlo Rossetti, Olivia Fechtner, Camille Maillard, Anne Hoffrichter, Eric Zillich, Ammar Jabali, Fabio Marsoner, Annasara Artioli, Ruven Wilkens, Christina B. Schroeter, Andreas Hentschel, Stephanie H. Witt, Nico Melzer, Sven G. Meuth, Tobias Ruck, Philipp Koch, Andreas Roos, Nadia Bahi-Buisson, Fiona Francis, Julia Ladewig   +21 more
doaj   +2 more sources

Structural and ensemble-based mechanistic insights into cytoplasmic dynein-1 [PDF]

Frontiers in Molecular Biosciences
Cytoplasmic dynein-1 is a multi-subunit motor that transports diverse cargoes toward microtubule minus-ends, playing crucial roles in intracellular organisation and cell division.
Amit Kumawat
doaj   +2 more sources