Results 41 to 50 of about 8,015 (203)

LIS1 determines cleavage plane positioning by regulating actomyosin-mediated cell membrane contractility

eLife, 2020
Heterozygous loss of human PAFAH1B1 (coding for LIS1) results in the disruption of neurogenesis and neuronal migration via dysregulation of microtubule (MT) stability and dynein motor function/localization that alters mitotic spindle orientation ...
Hyang Mi Moon, Simon Hippenmeyer, Liqun Luo, Anthony Wynshaw-Boris   +3 more
doaj   +1 more source

Abnormalities in Cortical GABAergic Interneurons of the Primary Motor Cortex Caused by Lis1 (Pafah1b1) Mutation Produce a Non-drastic Functional Phenotype

Frontiers in Cell and Developmental Biology, 2022
LIS1 (PAFAH1B1) plays a major role in the developing cerebral cortex, and haploinsufficient mutations cause human lissencephaly type 1. We have studied morphological and functional properties of the cerebral cortex of mutant mice harboring a deletion in ...
E. Domínguez-Sala, L. Valdés-Sánchez, S. Canals, O. Reiner, A. Pombero, R. García-López, A. Estirado, D. Pastor, E. Geijo-Barrientos, S. Martínez, S. Martínez   +10 more
doaj   +1 more source

Teaming up: from motors to people. [PDF]

, 2013
When I reflect on how I became a cell biologist and why I love being one today, one thing that comes to mind is the many terrific collaborations I have had.
Reck-Peterson, Samara L
core   +1 more source

LIS1 and Spindle Orientation in Neuroepithelial Cells [PDF]

Cell Stem Cell, 2008
Asymmetric stem cell division is thought to require precise orientation of the mitotic spindle. However, a recent study in Cell (Yingling et al., 2008) analyzes the role of LIS1 in the developing mouse brain and shows that spindle orientation is more important during early, symmetric progenitor cell divisions than for later asymmetric divisions.
Schwamborn, Jens C., Knoblich, Juergen A.   +1 more
openaire   +2 more sources

The LIS1/NDE1 Complex Is Essential for FGF Signaling by Regulating FGF Receptor Intracellular Trafficking

Cell Reports, 2018
Summary: Intracellular transport of membranous organelles and protein complexes to various destinations is fundamental to signaling transduction and cellular function.
Liansheng Liu, Jinqiu Lu, Xiaoling Li, Ailing Wu, Qingzhe Wu, Mujun Zhao, Nan Tang, Hai Song   +7 more
doaj   +1 more source

Global developmental gene expression and pathway analysis of normal brain development and mouse models of human neuronal migration defects. [PDF]

PLoS Genetics, 2011
Heterozygous LIS1 mutations are the most common cause of human lissencephaly, a human neuronal migration defect, and DCX mutations are the most common cause of X-linked lissencephaly.
Tiziano Pramparo, Ondrej Libiger, Sonia Jain, Hong Li, Yong Ha Youn, Shinji Hirotsune, Nicholas J Schork, Anthony Wynshaw-Boris   +7 more
doaj   +1 more source

A developmental and genetic classification for malformations of cortical development: update 2012. [PDF]

, 2012
Malformations of cerebral cortical development include a wide range of developmental disorders that are common causes of neurodevelopmental delay and epilepsy. In addition, study of these disorders contributes greatly to the understanding of normal brain
Barkovich, A James, Dobyns, William B, Guerrini, Renzo, Jackson, Graeme D, Kuzniecky, Ruben I   +4 more
core   +3 more sources

Developmental downregulation of LIS1 expression limits axonal extension and allows axon pruning

Biology Open, 2017
The robust axonal growth and regenerative capacities of young neurons decrease substantially with age. This developmental downregulation of axonal growth may facilitate axonal pruning and neural circuit formation but limits functional recovery following ...
Kanako Kumamoto, Tokuichi Iguchi, Ryuichi Ishida, Takuya Uemura, Makoto Sato, Shinji Hirotsune   +5 more
doaj   +1 more source

Locomotor hyperactivity in 14-3-3Zeta KO mice is associated with dopamine transporter dysfunction [PDF]

, 2013
Dopamine (DA) neurotransmission requires a complex series of enzymatic reactions that are tightly linked to catecholamine exocytosis and receptor interactions on pre- and postsynaptic neurons.
A Abi-Dargham, A Aitken, A Breier, A Vina-Vilaseca, AA Williams, AH Wong, B Giros, B Giros, BL Summers, BT Baune, C Itagaki, CA Tamminga, D Berg, D Sulzer, DL Levy, FA Middleton, H Fu, H Jaaro-Peled, H Khoshbouei, H Koike, HC Baxter, J Sun, J Wang, JA English, JA English, JA Lieberman, JA Lieberman, JH Son, JM van Rossum, K Toska, K Toyo-oka, K Toyo-Oka, KL Holton, M Laruelle, M Laruelle, M Miranda, M Rosner, M van den Buuse, M van den Buuse, MS Samuel, O Halskau Jr., P Coyle, PC Hart, PS Cheah, S Leucht, S Sivagnanasundaram, S Sivagnanasundaram, SG Amara, SR Jones, T Ichimura, T Ichimura, WC Drevets, WT Carpenter, Y Jia   +53 more
core   +2 more sources

Targeted mutagenesis of Lis1 disrupts cortical development and LIS1 homodimerization [PDF]

Proceedings of the National Academy of Sciences, 2001
Lissencephaly is a severe brain malformation in humans. To study the function of the gene mutated in lissencephaly ( LIS1 ), we deleted the first coding exon from the mouse Lis1 gene. The deletion resulted in a shorter protein (sLIS1) that initiates from the second methionine, a unique ...
Cahana, A., Escamez, T., Nowakowski, R., Hayes, N., Giacobini, M., Holst, A., Shmueli, O., Sapir, T., McConnell, S., Wurst, W., Martinez, S., Reiner, O.   +11 more
openaire   +3 more sources