Results 51 to 60 of about 2,714 (147)

Brain Pathways in LIS1-Associated Lissencephaly Revealed by Diffusion MRI Tractography

Brain Sciences, 2023
Lissencephaly (LIS) is a rare neurodevelopmental disorder with severe symptoms caused by abnormal neuronal migration during cortical development. It is caused by both genetic and non-genetic factors.
Alpen Ortug, Briana Valli, José Luis Alatorre Warren, Tadashi Shiohama, Andre van der Kouwe, Emi Takahashi   +5 more
doaj   +1 more source

Fighting Cancer Stem Cell Fate by Targeting LIS1 a WD40 Repeat Protein

Frontiers in Oncology, 2019
Cancer is one of the most frequent and devastating diseases. Previous reports have shown that radio and chemo-resistant cancer stem cell (CSC) population is primarily responsible for cancer recurrences after radiotherapy and chemotherapy.
Felix M. Brehar, Felix M. Brehar, Mihnea P. Dragomir, Mihnea P. Dragomir, George E. D. Petrescu, George E. D. Petrescu, Radu M. Gorgan, Radu M. Gorgan   +7 more
doaj   +1 more source

GENOTYPE-PHENOTYPE CORRELATION IN CASES WITH LISSENCEPHALY SPECTRUM

Sabiad, 2022
Objective: In this study, we aimed to evaluate six cases diagnosed with lissencephaly in terms of the genotype-phenotype correlation. Materials and Methods: Six cases with lissencephaly, which were followed up in our outpatient clinic, were included in ...
Ayça Dilruba Aslanger, Zehra Oya Uyguner, Birsen Karaman, Seher Başaran, Hülya Kayserili Karabey   +4 more
doaj   +1 more source

Lis1 puts mRNAs in their place [PDF]

Journal of Cell Biology, 2013
![Figure][1] The apical accumulation of hairy RNA (green) is reduced in an embryo lacking Lis1 (bottom) compared with a control embryo (top). Nuclei are labeled red. A protein associated with the neurodevelopmental disorder lissencephaly promotes the assembly of dynein–dynactin ...
openaire   +1 more source

Cytoplasmic dynein and its regulatory proteins in Golgi pathology in nervous system disorders

Frontiers in Neuroscience, 2015
The Golgi apparatus is a dynamic organelle involved in processing and sorting of lipids and proteins. In neurons, the Golgi apparatus is important for the development of axons and dendrites and maintenance of their highly polarized morphology.
Dick eJaarsma, Casper eHoogenraad
doaj   +1 more source

LIS1-Related Isolated Lissencephaly [PDF]

Archives of Neurology, 2009
With the largest data set of patients with LIS1-related lissencephaly, the major cause of posteriorly predominant lissencephaly related to either LIS1 mutation or intragenic deletion, described so far, we aimed to refine the spectrum of neurological and radiological features and to assess relationships with the genotype.Retrospective study.
Saillour, Yoann, Carion, Nathalie, Quelin, Chloe, Leger, Pierre-Louis, Boddaert, Nathalie, Elie, Caroline, Toutain, Annick, Mercier, Sandra, Barthez, Marie Anne, Milh, Mathieu, Joriot, Sylvie, Des Portes, Vincent, Philip, Nicole, Broglin, Dominique, Roubertie, Agathe, Pitelet, Gaëlle, Moutard, Marie Laure, Pinard, Jean-Marc, Cancès, Clément, Cances, Claude, Kaminska, Anna, Chelly, Jamel, Beldjord, Chérif, Bahi-Buisson, Nadia   +23 more
openaire   +3 more sources

NudEL targets dynein to microtubule ends through LIS1 [PDF]

Nature Cell Biology, 2005
Dynein is a minus-end-directed microtubule motor with critical roles in mitosis, membrane transport and intracellular transport. Several proteins regulate dynein activity, including dynactin, LIS1 (refs 2, 3) and NudEL (NudE-like). Here, we identify a NUDEL homologue in budding yeast and name it Ndl1. The ndl1delta null mutant shows decreased targeting
Jun, Li, Wei-Lih, Lee, John A, Cooper
openaire   +2 more sources

Lis1 is an initiation factor for dynein-driven organelle transport [PDF]

Journal of Cell Biology, 2012
The molecular motor cytoplasmic dynein is responsible for most minus-end–directed, microtubule-based transport in eukaryotic cells. It is especially important in neurons, where defects in microtubule-based motility have been linked to neurological diseases. For example, lissencephaly is caused by mutations in the dynein-associated protein Lis1. In this
Egan, Martin, Tan, Kaeling, Reck-Peterson, Samara L   +2 more
openaire   +4 more sources

A role for cytoplasmic dynein and LIS1 in directed cell movement [PDF]

The Journal of Cell Biology, 2003
Cytoplasmic dynein has been implicated in numerous aspects of intracellular movement. We recently found dynein inhibitors to interfere with the reorientation of the microtubule cytoskeleton during healing of wounded NIH3T3 cell monolayers. We now find that dynein and its regulators dynactin and LIS1 localize to the leading cell cortex during this ...
Dujardin, Denis L., Barnhart, Lora E., Stehman, Stephanie A., Gomes, Edgar R., Gundersen, Gregg G., Vallee, Richard B.   +5 more
openaire   +2 more sources

Genetic Mosaic Dissection of Lis1 and Ndel1 in Neuronal Migration [PDF]

Neuron, 2010
Coordinated migration of newly born neurons to their prospective target laminae is a prerequisite for neural circuit assembly in the developing brain. The evolutionarily conserved LIS1/NDEL1 complex is essential for neuronal migration in the mammalian cerebral cortex. The cytoplasmic nature of LIS1 and NDEL1 proteins suggest that they regulate neuronal
Hippenmeyer, Simon, Youn, Yong Ha, Moon, Hyang Mi, Miyamichi, Kazunari, Zong, Hui, Wynshaw-Boris, Anthony, Luo, Liqun   +6 more
openaire   +2 more sources