Results 51 to 60 of about 2,739 (166)
Cells, 2021 Cytoskeleton organization and lysosome secretion play an essential role in osteoclastogenesis and bone resorption. The cytoplasmic dynein is a molecular motor complex that regulates microtubule dynamics and transportation of cargos/organelles, including ...
Bhaba K. Das +6 more
doaj +1 more source
Lipid Droplet‐Localized Spindle Apparatus Coiled‐Coil Protein 1 Regulates Lipid Droplet Distribution
Advanced Science, Volume 13, Issue 14, 9 March 2026.SPDL1‐L, a long isoform of SPDL1, is identified as a bona fide lipid droplet‐associated protein that acts as a dynein adaptor to drive perinuclear clustering of lipid droplets. By linking lipid droplets to the microtubule network, SPDL1‐L extends the function of SPDL1 beyond mitosis and contributes to lipid droplet organization and nuclear remodeling ...
Honggang Su +10 more
wiley +1 more source
BMC Cancer, 2022 Objective To investigate the role of NudCD1 in spindle assembly checkpoint regulation and in the prognosis of colorectal cancer. Methods Immunohistochemical staining was used to detect in situ expression of NudCD1 in 100 colorectal cancer tissue samples.
Wen-Ming Feng +6 more
doaj +1 more source
Brain Pathways in LIS1-Associated Lissencephaly Revealed by Diffusion MRI Tractography
Brain Sciences, 2023 Lissencephaly (LIS) is a rare neurodevelopmental disorder with severe symptoms caused by abnormal neuronal migration during cortical development. It is caused by both genetic and non-genetic factors.
Alpen Ortug +5 more
doaj +1 more source
BioEssays, Volume 48, Issue 3, March 2026.Directional intracellular cargo transport is traditionally attributed to motor stepping along stationary microtubule (MT) tracks. We propose a complementary mechanism of cargo co‐migration with moving MTs. This mode requires cargo–MT tethering and directed MT motion.
Chuying Zhou, Mineko Kengaku
wiley +1 more source
Fighting Cancer Stem Cell Fate by Targeting LIS1 a WD40 Repeat Protein
Frontiers in Oncology, 2019 Cancer is one of the most frequent and devastating diseases. Previous reports have shown that radio and chemo-resistant cancer stem cell (CSC) population is primarily responsible for cancer recurrences after radiotherapy and chemotherapy.
Felix M. Brehar +7 more
doaj +1 more source
GENOTYPE-PHENOTYPE CORRELATION IN CASES WITH LISSENCEPHALY SPECTRUM
Sabiad, 2022 Objective: In this study, we aimed to evaluate six cases diagnosed with lissencephaly in terms of the genotype-phenotype correlation. Materials and Methods: Six cases with lissencephaly, which were followed up in our outpatient clinic, were included in ...
Ayça Dilruba Aslanger +4 more
doaj +1 more source
Lis1 puts mRNAs in their place [PDF]
Journal of Cell Biology, 2013 ![Figure][1] The apical accumulation of hairy RNA (green) is reduced in an embryo lacking Lis1 (bottom) compared with a control embryo (top). Nuclei are labeled red. A protein associated with the neurodevelopmental disorder lissencephaly promotes the assembly of dynein–dynactin ...
openaire +1 more source
Cytoplasmic dynein and its regulatory proteins in Golgi pathology in nervous system disorders
Frontiers in Neuroscience, 2015 The Golgi apparatus is a dynamic organelle involved in processing and sorting of lipids and proteins. In neurons, the Golgi apparatus is important for the development of axons and dendrites and maintenance of their highly polarized morphology.
Dick eJaarsma, Casper eHoogenraad
doaj +1 more source
Lipid Metabolism‐Driven CNS Repair via Targeted EV Delivery of PAF to Neurons
Journal of Extracellular Vesicles, Volume 15, Issue 2, February 2026.Encapsulation within GWEVs stabilizes platelet‐activating factor (PAF), prevents peripheral inflammation and enables targeted delivery across the blood–brain barrier. In the brain, GWEVs localize to injury sites and deliver PAF to neurons, where PAFAH1B1‐dependent cytoskeletal remodelling promotes repair, supporting GWEVs as a therapeutic platform for ...
Shih‐Yin Chen +10 more
wiley +1 more source