Results 61 to 70 of about 3,592 (196)

Lis1, the Drosophila homolog of a human lissencephaly disease gene, is required for germline cell division and oocyte differentiation

, 1999
Lissencephaly is a severe congenital brain malformation resulting from incomplete neuronal migration. One causal gene, LIS1, is homologous to nudF, a gene required for nuclear migration in A. nidulans. We have characterized the Drosophila homolog of LIS1
Liu, Zhao, Xie, Ting, Steward, Ruth
core   +1 more source

Mechanism Of Lis1 In Promoting Perineural Invasion Of Hnscc

International Dental Journal
Aim or purpose: This study investigates the role of LIS1 in promoting perineural invasion (PNI) and metastasis in HNSCC. Materials and methods: LIS1 expression was assessed in HNSCC using TCGA datasets. To evaluate the correlation between LIS1 and PNI in
Ao Dai, Lu Gao, Xiang yu Zhu
doaj   +1 more source

Lissencephaly-1 is a context-dependent regulator of the human dynein complex

eLife, 2017
The cytoplasmic dynein-1 (dynein) motor plays a central role in microtubule organisation and cargo transport. These functions are spatially regulated by association of dynein and its accessory complex dynactin with dynamic microtubule plus ends. Here, we
Janina Baumbach, Andal Murthy, Mark A McClintock, Carly I Dix, Ruta Zalyte, Ha Thi Hoang, Simon L Bullock   +6 more
doaj   +1 more source

NudCD1 as a prognostic marker in colorectal cancer and its role in the upregulation of cellular spindle assembly checkpoint genes and LIS1 pathways

BMC Cancer, 2022
Objective To investigate the role of NudCD1 in spindle assembly checkpoint regulation and in the prognosis of colorectal cancer.  Methods Immunohistochemical staining was used to detect in situ expression of NudCD1 in 100 colorectal cancer tissue samples.
Wen-Ming Feng, Hui Gong, Yong-Chun Wang, Yao Wang, Tao Xue, Ting Zhang, Ge Cui   +6 more
doaj   +1 more source

The Cytoplasmic Dynein Associated Protein NDE1 Regulates Osteoclastogenesis by Modulating M-CSF and RANKL Signaling Pathways

Cells, 2021
Cytoskeleton organization and lysosome secretion play an essential role in osteoclastogenesis and bone resorption. The cytoplasmic dynein is a molecular motor complex that regulates microtubule dynamics and transportation of cargos/organelles, including ...
Bhaba K. Das, Jyoti Gogoi, Aarthi Kannan, Ling Gao, Weirong Xing, Subburaman Mohan, Haibo Zhao   +6 more
doaj   +1 more source

Lis1 slows force-induced detachment of cytoplasmic dynein from microtubules. [PDF]

Lis1 is a key cofactor for the assembly of active cytoplasmic dynein complexes that transport cargo along microtubules. Lis1 binds to the AAA+ ring and stalk of dynein and slows dynein motility, but the underlying mechanism has remained unclear.
Yildiz, Ahmet, Kusakci, Emre, Zhao, Yuanchang, Htet, Zaw, Reck-Peterson, Samara, Gillies, John   +5 more
core   +1 more source

Fighting Cancer Stem Cell Fate by Targeting LIS1 a WD40 Repeat Protein

Frontiers in Oncology, 2019
Cancer is one of the most frequent and devastating diseases. Previous reports have shown that radio and chemo-resistant cancer stem cell (CSC) population is primarily responsible for cancer recurrences after radiotherapy and chemotherapy.
Felix M. Brehar, Felix M. Brehar, Mihnea P. Dragomir, Mihnea P. Dragomir, George E. D. Petrescu, George E. D. Petrescu, Radu M. Gorgan, Radu M. Gorgan   +7 more
doaj   +1 more source

Brain Pathways in LIS1-Associated Lissencephaly Revealed by Diffusion MRI Tractography

Brain Sciences, 2023
Lissencephaly (LIS) is a rare neurodevelopmental disorder with severe symptoms caused by abnormal neuronal migration during cortical development. It is caused by both genetic and non-genetic factors.
Alpen Ortug, Briana Valli, José Luis Alatorre Warren, Tadashi Shiohama, Andre van der Kouwe, Emi Takahashi   +5 more
doaj   +1 more source

The Long Haul: Microtubule Motors as the Essential Supply Line for Neuronal Longevity

Journal of Neurochemistry, Volume 170, Issue 6, June 2026.
To survive a lifetime, neurons depend on a high‐fidelity logistics network powered by microtubule motors. We explore how a broad spectrum of genetic defects in this machinery drive a devastating spectrum of neurodevelopmental and neurodegenerative diseases, including Hereditary Spastic Paraplegia (HSP), Charcot–Marie‐Tooth Type 2 (CMT2), and ...
Emma D. Turner, Alison E. Twelvetrees
wiley   +1 more source

Lis1 puts mRNAs in their place [PDF]

Journal of Cell Biology, 2013
![Figure][1] The apical accumulation of hairy RNA (green) is reduced in an embryo lacking Lis1 (bottom) compared with a control embryo (top). Nuclei are labeled red. A protein associated with the neurodevelopmental disorder lissencephaly promotes the assembly of dynein–dynactin ...
openaire   +1 more source