Results 61 to 70 of about 8,015 (203)

Lipid Droplet‐Localized Spindle Apparatus Coiled‐Coil Protein 1 Regulates Lipid Droplet Distribution

Advanced Science, Volume 13, Issue 14, 9 March 2026.
SPDL1‐L, a long isoform of SPDL1, is identified as a bona fide lipid droplet‐associated protein that acts as a dynein adaptor to drive perinuclear clustering of lipid droplets. By linking lipid droplets to the microtubule network, SPDL1‐L extends the function of SPDL1 beyond mitosis and contributes to lipid droplet organization and nuclear remodeling ...
Honggang Su, Huimin Pan, Yaqiang Liu, Wei Wang, Yang Jiao, Yumo Hang, Xiahe Huang, Yong E. Zhang, Yuhang Chen, Mei Ding, Xun Huang   +10 more
wiley   +1 more source

LIS1-Related Isolated Lissencephaly [PDF]

Archives of Neurology, 2009
With the largest data set of patients with LIS1-related lissencephaly, the major cause of posteriorly predominant lissencephaly related to either LIS1 mutation or intragenic deletion, described so far, we aimed to refine the spectrum of neurological and radiological features and to assess relationships with the genotype.Retrospective study.
Saillour, Yoann, Carion, Nathalie, Quelin, Chloe, Leger, Pierre-Louis, Boddaert, Nathalie, Elie, Caroline, Toutain, Annick, Mercier, Sandra, Barthez, Marie Anne, Milh, Mathieu, Joriot, Sylvie, Des Portes, Vincent, Philip, Nicole, Broglin, Dominique, Roubertie, Agathe, Pitelet, Gaëlle, Moutard, Marie Laure, Pinard, Jean-Marc, Cancès, Clément, Cances, Claude, Kaminska, Anna, Chelly, Jamel, Beldjord, Chérif, Bahi-Buisson, Nadia   +23 more
openaire   +3 more sources

Both doublecortin and doublecortin-like kinase play a role in cortical interneuron migration [PDF]

, 2007
Type I lissencephaly, a genetic disease characterized by disorganized cortical layers and gyral abnormalities, is associated with severe cognitive impairment and epilepsy.
Antypa, M, Friocourt, G, Liu, JS, Parnavelas, JG, Rakic, S, Walsh, CA   +5 more
core   +1 more source

Motor‐Assisted Co‐Migration of Intracellular Organelles and Microtubules as a Mechanism for Directed Cargo Transport

BioEssays, Volume 48, Issue 3, March 2026.
Directional intracellular cargo transport is traditionally attributed to motor stepping along stationary microtubule (MT) tracks. We propose a complementary mechanism of cargo co‐migration with moving MTs. This mode requires cargo–MT tethering and directed MT motion.
Chuying Zhou, Mineko Kengaku
wiley   +1 more source

Mechanism Of Lis1 In Promoting Perineural Invasion Of Hnscc

International Dental Journal
Aim or purpose: This study investigates the role of LIS1 in promoting perineural invasion (PNI) and metastasis in HNSCC. Materials and methods: LIS1 expression was assessed in HNSCC using TCGA datasets. To evaluate the correlation between LIS1 and PNI in
Ao Dai, Lu Gao, Xiang yu Zhu
doaj   +1 more source

The Cytoplasmic Dynein Associated Protein NDE1 Regulates Osteoclastogenesis by Modulating M-CSF and RANKL Signaling Pathways

Cells, 2021
Cytoskeleton organization and lysosome secretion play an essential role in osteoclastogenesis and bone resorption. The cytoplasmic dynein is a molecular motor complex that regulates microtubule dynamics and transportation of cargos/organelles, including ...
Bhaba K. Das, Jyoti Gogoi, Aarthi Kannan, Ling Gao, Weirong Xing, Subburaman Mohan, Haibo Zhao   +6 more
doaj   +1 more source

Lissencephaly-1 is a context-dependent regulator of the human dynein complex

eLife, 2017
The cytoplasmic dynein-1 (dynein) motor plays a central role in microtubule organisation and cargo transport. These functions are spatially regulated by association of dynein and its accessory complex dynactin with dynamic microtubule plus ends. Here, we
Janina Baumbach, Andal Murthy, Mark A McClintock, Carly I Dix, Ruta Zalyte, Ha Thi Hoang, Simon L Bullock   +6 more
doaj   +1 more source

Brain Pathways in LIS1-Associated Lissencephaly Revealed by Diffusion MRI Tractography

Brain Sciences, 2023
Lissencephaly (LIS) is a rare neurodevelopmental disorder with severe symptoms caused by abnormal neuronal migration during cortical development. It is caused by both genetic and non-genetic factors.
Alpen Ortug, Briana Valli, José Luis Alatorre Warren, Tadashi Shiohama, Andre van der Kouwe, Emi Takahashi   +5 more
doaj   +1 more source

The mitosis and neurodevelopment proteins NDE1 and NDEL1 form dimers, tetramers and polymers with a folded-back structure in solution [PDF]

, 2012
Paralogs NDE1 (nuclear distribution element 1) and NDEL1 (NDE-like 1) are essential for mitosis and neurodevelopment. Both proteins are predicted to have similar structures, based upon high sequence similarity, and they co-complex in mammalian cells.
Alkuraya, Bakircioglu, Bariola, Bradshaw, Bradshaw, Bradshaw, Bradshaw, Brandon, Braun, Burdick, Chansard, Chen, Collins, Cox, Derewenda, Efimov, Feng, Guo, Hayashi, Ikeda, Ingason, Johnson, Kalkhof, Kirov, Lam, Laskowski, Leliveld, Liang, Ludtke, Magri, Maiolica, Matic, Mori, Narayanan, Need, Niethammer, Ong, Rappsilber, Rappsilber, Rappsilber, Sali, Sasaki, Segal, Shen, Shmueli, Tarricone, Toyo-oka, Ullmann, van Heel, Vriend, Wang, Yan, Zylkiewicz   +52 more
core   +1 more source

Lipid Metabolism‐Driven CNS Repair via Targeted EV Delivery of PAF to Neurons

Journal of Extracellular Vesicles, Volume 15, Issue 2, February 2026.
Encapsulation within GWEVs stabilizes platelet‐activating factor (PAF), prevents peripheral inflammation and enables targeted delivery across the blood–brain barrier. In the brain, GWEVs localize to injury sites and deliver PAF to neurons, where PAFAH1B1‐dependent cytoskeletal remodelling promotes repair, supporting GWEVs as a therapeutic platform for ...
Shih‐Yin Chen, Jing‐Ya Hsu, Chen‐Fu Lo, Yu‐Wei Liu, Wei‐Neng Liao, Wen‐Ting Luo, Yu‐Ju Chen, Jui‐Ping Li, Jen‐Kun Chen, Lun Kelvin Tsou, Hua‐Jung Li   +10 more
wiley   +1 more source