Results 61 to 70 of about 2,714 (147)

Stress-Induced CDK5 Activation Disrupts Axonal Transport via Lis1/Ndel1/Dynein

Cell Reports, 2015
Axonal transport is essential for neuronal function, and defects in transport are associated with multiple neurodegenerative diseases. Aberrant cyclin-dependent kinase 5 (CDK5) activity, driven by the stress-induced activator p25, also is observed in ...
Eva Klinman, Erika L.F. Holzbaur
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Lis1 finds new digs on the desmosome [PDF]

Journal of Cell Biology, 2011
![Figure][1] The centrosomal protein Lis1 (green) localizes to the cortex of differentiated epithelial cells. A protein that stabilizes microtubules also helps maintain desmosomes, [Sumigray et al.][2] report.
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An Organoid-Based Model of Cortical Development Identifies Non-Cell-Autonomous Defects in Wnt Signaling Contributing to Miller-Dieker Syndrome

Cell Reports, 2017
Miller-Dieker syndrome (MDS) is caused by a heterozygous deletion of chromosome 17p13.3 involving the genes LIS1 and YWHAE (coding for 14.3.3ε) and leads to malformations during cortical development.
Vira Iefremova, George Manikakis, Olivia Krefft, Ammar Jabali, Kevin Weynans, Ruven Wilkens, Fabio Marsoner, Björn Brändl, Franz-Josef Müller, Philipp Koch, Julia Ladewig   +10 more
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Load-induced enhancement of Dynein force production by LIS1–NudE in vivo and in vitro

Nature Communications, 2016
Transport of large cargo through the cytoplasm can encounter physical impediments which should be overcome. Here the authors show that lipid droplets constrained by an optical trap respond with an increase in dynein-mediated force that is dependent on ...
Babu J. N. Reddy, Michelle Mattson, Caitlin L. Wynne, Omid Vadpey, Abdo Durra, Dail Chapman, Richard B. Vallee, Steven P. Gross   +7 more
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Structural and Diffusion MRI Analyses With Histological Observations in Patients With Lissencephaly

Frontiers in Cell and Developmental Biology, 2019
The development of cortical convolutions, gyri and sulci, is a complex process that takes place during prenatal development. Lissencephaly, a rare genetic condition characterized by the lack of cortical convolutions, offers a model to look into ...
Lana Vasung, Lana Vasung, Arthur Rezayev, Arthur Rezayev, Hyuk Jin Yun, Hyuk Jin Yun, Jae W. Song, Andre van der Kouwe, Natalie Stewart, Natalie Stewart, Arthi Palani, Arthi Palani, Tadashi Shiohama, Tadashi Shiohama, Tadashi Shiohama, Francois Chouinard-Decorte, Jacob Levman, Jacob Levman, Jacob Levman, Emi Takahashi, Emi Takahashi   +20 more
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Lis1 cuts its work short

Journal of Cell Biology, 2012
![Figure][1] Endosomes (green) move in normal fungi (top) but stay put if Lis1 is absent (bottom). Egan et al. clarify the role of the dynein co-factor Lis1 in cargo transport. The molecular motor dynein ferries cargoes toward the minus ends of microtubules, typically toward the nucleus.
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Identification of novel Lis1 protein interaction partners: Investigations towards cellular Lis1 functions

, 2010
Die Haploinsuffizienz des Lis1 führt beim Menschen zu der Lissenzephalie Typ 1. Mausmutanten mit homozygotem Lis1 sind vorgeburtlich letal, und männliche Mäuse mit einer Genfalle im Lis1 Lokus sind infertil und zeigen eine deutlich verringerte Spermienzahl. Diese Mutationen verdeutlichen die tragende Bedeutung von Lis1 in unterschiedlichen Zellen. Mit
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LIS1 Missense Mutations [PDF]

Journal of Biological Chemistry, 2003
Michal Caspi, Frédéric M. Coquelle, Cynthia Koifman, Talia Levy, Hiroyuki Arai, Junken Aoki, Jan R. De Mey, Orly Reiner   +7 more
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LIS1 and DCX: Implications for Brain Development and Human Disease in Relation to Microtubules

Scientifica, 2013
Proper lamination of the cerebral cortex requires the orchestrated motility of neurons from their place of birth to their final destination. Improper neuronal migration may result in a wide range of diseases, including brain malformations, such as ...
Orly Reiner
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LIS1 [PDF]

Neuron, 2000
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