Results 81 to 90 of about 8,015 (203)

Rab-mediated vesicular transport is required for neuronal positioning in the developing Drosophila visual system [PDF]

, 2010
Background The establishment of tissue architecture in the nervous system requires the proper migration and positioning of newly born neurons during embryonic development.
Tarek Houalla, Lei Shi, Donald J van Meyel, Yong Rao   +3 more
core   +2 more sources

Postnatal Mouse Brain Region‐Resolved Peptidomic Resource of Conditional Ndel1 Loss: Comparison of Acidic and Alcoholic Extraction Strategies

Journal of Neurochemistry, Volume 169, Issue 12, December 2025.
The Ndel1 protein is crucial for neurodevelopment, but its role in the brain peptidome is unknown. Here we compared the peptidome of Ndel1 conditional knockout (Ndel1_cKO) mice with controls (CTRL) in four brain regions. Peptides were extracted using acidic (Acetic Acid, AcOH) and organic (Methanol, MeOH) methods and analyzed by Liquid Chromatography ...
João V. Nani, Jackelinne Yuka Hayashi, Joana D. Campeiro, Guilherme Araújo Câmara, Atsushi Saito, William Y. Oyadomari, Akira Sawa, Atsushi Kamiya, Alexandre K. Tashima, Mirian A. F. Hayashi   +9 more
wiley   +1 more source

Cytoplasmic dynein and its regulatory proteins in Golgi pathology in nervous system disorders

Frontiers in Neuroscience, 2015
The Golgi apparatus is a dynamic organelle involved in processing and sorting of lipids and proteins. In neurons, the Golgi apparatus is important for the development of axons and dendrites and maintenance of their highly polarized morphology.
Dick eJaarsma, Casper eHoogenraad
doaj   +1 more source

Diagnosis and treatment of occipital brain lesions in children

Developmental Medicine &Child Neurology, Volume 67, Issue 11, Page 1409-1420, November 2025.
Occipital brain lesions in children represent a diagnostic challenge due to the large spectrum of etiologies and overlapping clinical features. This review analyses common and less common causes of occipital brain lesions in children, including malformative, vascular, genetic/metabolic, infectious, inflammatory, and neoplastic conditions.
Luca Bartolini, Giulia Savoca, Matteo Tassone, Tiziana Metitieri, Renzo Guerrini   +4 more
wiley   +1 more source

Malformations of cortical development: Embryology and epilepsy

Epilepsia, Volume 66, Issue 10, Page 3642-3655, October 2025.
Abstract One in seven patients with focal epilepsy has a malformation of cortical development (MCD) as underlying cause. Understanding normal cortical development combined with knowledge of where, when, and what goes wrong in different types of MCD provides insight into the mechanisms of epileptogenesis.
M. Christianne Hoeberigs, Simon Tousseyn, on behalf of the ACE Study Group, Gwendolyn de Bruyn, Albert Colon, Jim Dings, Marc Hendriks, Danny Hilkman, Christianne Hoeberigs, Jochem van der Pol, Lotte de Jong, Kim Rijkers, Sylvia Klinkenberg, Vivianne van Kranen Mastenbroek, Jeske Nelissen, Pieter Kubben, Walter M. Palm, Rob P. W. Rouhl, Remco Santegoeds, Olaf Schijns, Ilse van Straaten, Marielle Vlooswijk, Louis Wagner, Dorien Weckhuysen   +23 more
wiley   +1 more source

Aetiopathogenesis of infantile epileptic spasms syndrome and mechanisms of action of adrenocorticotrophin hormone/corticosteroids in children: A scoping review

Developmental Medicine &Child Neurology, Volume 67, Issue 8, Page 1004-1025, August 2025.
Why does infantile epileptic spasms syndrome (IESS) occur with a variety of underlying conditions and why does it respond to adrenocorticotrophin hormone (ACTH)/corticosteroids? Our scoping review summarizes five hypotheses from the literature: gene/epigenetic regulation, stress/HPA axis activation, neuroinflammation/immune function, altered neuronal ...
Emily A. Innes, Velda X. Han, Shrujna Patel, Michelle A. Farrar, Deepak Gill, Shekeeb S. Mohammad, Russell C. Dale   +6 more
wiley   +1 more source

Increased LIS1 expression affects human and mouse brain development [PDF]

Nature Genetics, 2009
Deletions of the PAFAH1B1 gene (encoding LIS1) in 17p13.3 result in isolated lissencephaly sequence, and extended deletions including the YWHAE gene (encoding 14-3-3epsilon) cause Miller-Dieker syndrome. We identified seven unrelated individuals with submicroscopic duplication in 17p13.3 involving the PAFAH1B1 and/or YWHAE genes, and using a 'reverse ...
Bi, Weimin, Sapir, Tamar, Shchelochkov, Oleg A., Zhang, Feng, Withers, Marjorie A., Hunter, Jill V., Levy, Talia, Shinder, Vera, Peiffer, Daniel A., Gunderson, Kevin L., Nezarati, Marjan M., Shotts, Vern Ann, Amato, Stephen S., Savage, Sarah K., Harris, David James, Day-Salvatore, Debra-Lynn, Horner, Michele, Lu, Xin-Yan, Sahoo, Trilochan, Yanagawa, Yuchio, Beaudet, Arthur L., Cheung, Sau Wai, Martínez, Salvador, Lupski, James R., Reiner, Orly   +24 more
openaire   +3 more sources

Centromere Protein F in Tumor Biology: Cancer's Achilles Heel

Cancer Medicine, Volume 14, Issue 10, May 2025.
ABSTRACT Background Centromere protein F (CENP‐F) is an important nuclear matrix protein that regulates mitosis and the cell cycle, and plays a crucial role in recruiting spindle checkpoint proteins to maintain the accuracy of chromosome segregation.
Zitong Wan, Miaomiao Wen, Chunlong Zheng, Ying Sun, Yinxi Zhou, Yahui Tian, Shaowei Xin, Xuejiao Wang, Xiaohong Ji, Jie Yang, Yanlu Xiong, Yong Han   +11 more
wiley   +1 more source

Supporting process reuse in PROMENADE [PDF]

, 2002
Process reuse (the ability to construct new processes by assembling already built ones) and process harvesting (the ability to build generic processes that may be further reused, from existing ones) are two crucial issues in process technology.
Franch Gutiérrez, Javier, Ribó Trujillo, Josep M.   +1 more
core   +1 more source

Conformational heterogeneity coupled with β-fibril formation of a scaffold protein involved in chronic mental illnesses

Translational Psychiatry, 2021
Chronic mental illnesses (CMIs) pose a significant challenge to global health due to their complex and poorly understood etiologies and hence, absence of causal therapies.
Abhishek Cukkemane, Nina Becker, Mara Zielinski, Benedikt Frieg, Nils-Alexander Lakomek, Henrike Heise, Gunnar F. Schröder, Dieter Willbold, Oliver H. Weiergräber   +8 more
doaj   +1 more source