Results 91 to 100 of about 8,015 (203)

Non-cell autonomous and non-catalytic activities of ATX in the developing brain [PDF]

, 2015
The intricate formation of the cerebral cortex requires a well-coordinated series of events, which are regulated at the level of cell-autonomous and non-cell autonomous mechanisms. Whereas cell-autonomous mechanisms that regulate cortical development are
Anna Gorelik, Jan Baumgart, Johannes Vogt, Junken Aoki, Michal Segal-Salto, Orly Reiner, Raanan Greenman, Robert Nitsch, Smadar Levin-Zaidman, Tamar Sapir, Vanessa Zamor, Vassilis Aidinis   +11 more
core   +2 more sources

BicD and MAP7 Collaborate to Activate Homodimeric Drosophila Kinesin‐1 by Complementary Mechanisms

Traffic, Volume 26, Issue 4-6, April‐June 2025.
Kinesin‐1 is auto‐inhibited and binds microtubules weakly. Binding of kinesin‐1 to the adaptor protein BicD enhances processive motion, while the microtubule‐associated protein MAP7 recruits more kinesin to the microtubule and enhances run length.
M. Yusuf Ali, Hailong Lu, Patricia M. Fagnant, Jill E. Macfarlane, Kathleen M. Trybus   +4 more
wiley   +1 more source

Lis1 cuts its work short

Journal of Cell Biology, 2012
![Figure][1] Endosomes (green) move in normal fungi (top) but stay put if Lis1 is absent (bottom). Egan et al. clarify the role of the dynein co-factor Lis1 in cargo transport. The molecular motor dynein ferries cargoes toward the minus ends of microtubules, typically toward the nucleus.
openaire   +2 more sources

Stress-Induced CDK5 Activation Disrupts Axonal Transport via Lis1/Ndel1/Dynein

Cell Reports, 2015
Axonal transport is essential for neuronal function, and defects in transport are associated with multiple neurodegenerative diseases. Aberrant cyclin-dependent kinase 5 (CDK5) activity, driven by the stress-induced activator p25, also is observed in ...
Eva Klinman, Erika L.F. Holzbaur
doaj   +1 more source

Basic mechanisms of MCD in animal models.

, 2009
International audienceEpilepsy-associated glioneuronal malformations (malformations of cortical development [MCD]) include focal cortical dysplasias (FCD) and highly differentiated glioneuronal tumors, most frequently gangliogliomas.
Baraban, Scott,, Battaglia, Giorgio, Becker, Albert,, LoTurco, Joseph, Represa, Alfonso, Roper, Steven,, Vezzani, Annamaria   +6 more
core   +3 more sources

Transducin beta-like gene FTL1 is essential for pathogenesis in Fusarium graminearum [PDF]

, 2009
Fusarium head blight caused by Fusarium graminearum is an important disease of wheat and barley. In a previous study, we identified several mutants with reduced virulence by insertional mutagenesis. A transducin beta-like gene named FTL1 was disrupted in
Ding, S.L., Mehrabi, R., Koten, C., Kang, Z.S., Wei, Y.D., Seong, K., Corby Kistler, H., Xu, J.R.   +7 more
core   +2 more sources

At the nucleus of cancer: how the nuclear envelope controls tumor progression

MedComm, Volume 6, Issue 2, February 2025.
The review is focused on exploring novel intriguing perspectives on the role of the nuclear envelope in tumor progression. Alterations of nuclear envelope proteins result in the dysregulation of cellular pathways and promote tumorigenesis, highlighting that complex regulatory mechanisms lie behind the alterations in nuclear shape in cancer, thus ...
Francesca Paganelli, Alessandro Poli, Serena Truocchio, Alberto M. Martelli, Carla Palumbo, Giovanna Lattanzi, Francesca Chiarini   +6 more
wiley   +1 more source

14‐3‐3ε conditional knockout mice exhibit defects in the development of the epidermis

FEBS Letters, Volume 598, Issue 24, Page 3005-3020, December 2024.
A knockout of 14‐3‐3ε in the basal layer of the epidermis in mice leads to a decrease in proliferation and the thickness of the epidermis and decreased expression of differentiation markers. The knockout cells also show centrosome amplification, suggesting that centrosome amplification leads to decreased proliferation and subsequent thinning of the ...
Sarika Tilwani, Karan Gandhi, Sorab N. Dalal   +2 more
wiley   +1 more source

Linking secretion and cytoskeleton in immunity– a case for Arabidopsis TGNap1

BioEssays, Volume 46, Issue 11, November 2024.
Intracellular trafficking, particularly in defense, depends on F‐actin and microtubules (MTs). Cytoskeleton‐Organelle Bridging Proteins (COBPs) link vesicles to these structures, ensuring directional transport. While the specifics of this association are unclear, TGNap1 has been identified as a crucial MT‐binding COBP for defense trafficking ...
Deepak D. Bhandari, Federica Brandizzi
wiley   +1 more source

Lis1 puts mRNAs in their place [PDF]

Journal of Cell Biology, 2013
![Figure][1] The apical accumulation of hairy RNA (green) is reduced in an embryo lacking Lis1 (bottom) compared with a control embryo (top). Nuclei are labeled red. A protein associated with the neurodevelopmental disorder lissencephaly promotes the assembly of dynein–dynactin ...
openaire   +1 more source