Results 111 to 120 of about 3,592 (196)

Differential Effects of LIS1 On Processive Dynein-Dynactin Motility

, 2017
Cytoplasmic dynein is the primary minus-end directed microtubule motor protein in cells. LIS1 is a highly conserved dynein regulatory factor that binds directly to the dynein motor domain, uncoupling the enzymatic and mechanical cycles of the motor, and ...
Richard J. McKenney, Pedro A. Gutierrez
core   +1 more source

LIS1 Missense Mutations [PDF]

Journal of Biological Chemistry, 2003
Michal Caspi, Frédéric M. Coquelle, Cynthia Koifman, Talia Levy, Hiroyuki Arai, Junken Aoki, Jan R. De Mey, Orly Reiner   +7 more
openaire   +1 more source

LncRNA RASAL2-AS1 promotes METTL14-mediated m6A methylation in the proliferation and progression of head and neck squamous cell carcinoma

Cancer Cell International
Background Long non-coding RNAs (lncRNAs) are key regulators of the 6-methyladenosine (m6A) epigenetic modification, playing a role in the initiation and progression of tumors.
Meiting Rong, Ming Zhang, Feihong Dong, Ke Wu, Bingkun Cai, Jinrui Niu, Le Yang, Zhongyan Li, Hui-yi Lu   +8 more
doaj   +1 more source

LIS1 and DCX: Implications for Brain Development and Human Disease in Relation to Microtubules

Scientifica, 2013
Proper lamination of the cerebral cortex requires the orchestrated motility of neurons from their place of birth to their final destination. Improper neuronal migration may result in a wide range of diseases, including brain malformations, such as ...
Orly Reiner
doaj   +1 more source

LIS1 [PDF]

Neuron, 2000
openaire   +1 more source

Interaction between LIS1 and PDE4, and its role in cytoplasmic dynein function

, 2011
LIS1, a WD40 repeat scaffold protein, interacts with components of the cytoplasmic dynein motor complex to regulate dynein-dependent cell motility. Here, we reveal that cAMP-specific phosphodiesterases (PDE4s) directly bind PAFAH1B1 (also known as LIS1).
Dunlop, A.J., Prinz, Anke, Vadrevu, Suryakiran, Miles D. Houslay, Prinz, A., Suryakiran Vadrevu, Vadrevu, S., Klussmann, E., James C. Norman, Murdoch, Hannah, Klussmann, Enno, Allan J. Dunlop, Bolger, Graeme B., Houslay, Miles D., Anke Prinz, Dunlop, Allan J., Bolger, G.B., Murdoch, H., Graeme B. Bolger, Norman, J.C., Enno Klussmann, Hannah Murdoch, Bolger, G. B., Houslay, M.D., Norman, J. C., Norman, James C.   +25 more
core   +1 more source

Kampen om LIS1

Tidsskrift for Den norske legeforening, 2022
openaire   +1 more source

Ndel1 Operates in a Common Pathway with LIS1 and Cytoplasmic Dynein to Regulate Cortical Neuronal Positioning

, 2004
Correct neuronal migration and positioning during cortical development are essential for proper brain function. Mutations of the LIS1 gene result in human lissencephaly (smooth brain), which features misplaced cortical neurons and disarrayed cerebral ...
Nguyen, Minh-Dang, Ayala, Ramses, Xie, Zhigang, Shu, Tianzhi, Tsai, Li-Huei, Gleeson, Joseph G.   +5 more
core   +1 more source

Lis1 and doublecortin function with dynein to mediate coupling of the nucleus to the centrosome in neuronal migration [PDF]

, 2004
Humans with mutations in either DCX or LIS1 display nearly identical neuronal migration defects, known as lissencephaly. To define subcellular mechanisms, we have combined in vitro neuronal migration assays with retroviral transduction. Overexpression of
Tanaka, T, Wynshaw-Boris, A, Gambello, M J, Serneo, F F, Gleeson, J G, Higgins, C   +5 more
core  

A role for the lissencephaly gene LIS1 in mitosis and cytoplasmic dynein function

, 2008
Mutations in the LIS1 gene cause gross histological disorganization of the developing human brain, resulting in a brain surface that is almost smooth.
Wang, Yu-Li, O'Connell, Christopher B., Tai, Chin-Yin, Vaughan, Kevin T., Dujardin, Denis L., Vallee, Richard B., Faulkner, Nicole E.   +6 more
core   +1 more source