Results 101 to 110 of about 3,592 (196)

Load-induced enhancement of Dynein force production by LIS1–NudE in vivo and in vitro

Nature Communications, 2016
Transport of large cargo through the cytoplasm can encounter physical impediments which should be overcome. Here the authors show that lipid droplets constrained by an optical trap respond with an increase in dynein-mediated force that is dependent on ...
Babu J. N. Reddy, Michelle Mattson, Caitlin L. Wynne, Omid Vadpey, Abdo Durra, Dail Chapman, Richard B. Vallee, Steven P. Gross   +7 more
doaj   +1 more source

LIS1 Is Critical for Axon Integrity in Adult Mice

The Journal of Neuroscience
Mutations in human LIS1 cause lissencephaly, a severe developmental brain malformation. Although most studies focus on development, LIS1 is also expressed in adult mouse tissues. We previously induced LIS1 knock-out (iKO) in adult mice using a Cre-Lox approach with an actin promoter driving CreERT2 expression.
Samaneh Matoo, Anne M. Ventrone, Shreena Patel, Jack K. Otterson, Sean Noonan, Noah Leever, Timothy J. Hines, Ashley L. Kalinski, Deanna S. Smith   +8 more
openaire   +1 more source

A LIS1/NUDEL/Cytoplasmic Dynein Heavy Chain Complex in the Developing and Adult Nervous System

, 2000
Mutations in mammalian Lis1 (Pafah1b1) result in neuronal migration defects. Several lines of evidence suggest that LIS1 participates in pathways regulating microtubule function, but the molecular mechanisms are unknown.
Wynshaw-Boris, Anthony, Gambello, Michael J., Sasaki, Shinji, Yingling, Jessica, Shionoya, Aki, Hirotsune, Shinji, Ishida, Michiyo   +6 more
core   +1 more source

Structural and Diffusion MRI Analyses With Histological Observations in Patients With Lissencephaly

Frontiers in Cell and Developmental Biology, 2019
The development of cortical convolutions, gyri and sulci, is a complex process that takes place during prenatal development. Lissencephaly, a rare genetic condition characterized by the lack of cortical convolutions, offers a model to look into ...
Lana Vasung, Lana Vasung, Arthur Rezayev, Arthur Rezayev, Hyuk Jin Yun, Hyuk Jin Yun, Jae W. Song, Andre van der Kouwe, Natalie Stewart, Natalie Stewart, Arthi Palani, Arthi Palani, Tadashi Shiohama, Tadashi Shiohama, Tadashi Shiohama, Francois Chouinard-Decorte, Jacob Levman, Jacob Levman, Jacob Levman, Emi Takahashi, Emi Takahashi   +20 more
doaj   +1 more source

Poster Sessions

HemaSphere, Volume 10, Issue S1, June 2026.
wiley   +1 more source

Immediate Therapeutic Response to Vigabatrin in Lissencephaly‐Related Epileptic Spasms due to TUBA1A R402H Variant

American Journal of Medical Genetics Part A, Volume 197, Issue 7, July 2025.
Toru Nagata, Takashi Shibata, Hiroki Tsuchiya, Mari Akiyama, Mitsuhiro Kato, Tomoyuki Akiyama, Toshiki Takenouchi   +6 more
wiley   +1 more source

Overexpression of <i>Lis1</i> in Different Stages of Spermatogenesis Does Not Result in an Aberrant Phenotype

, 2011
Previous studies showed that in the mouse mutant <i>Lis1</i>^GT/GT gene trap integration in intron 2 of <i>Lis1</i> gene leads to male infertility in homozygous <i>Lis1</i><sup>GT/GT</sup&
Nayernia, K., A. Meinhardt, Jung, B., W. Engel, H.-H. Arnold, K. Nayernia, Engel, Wolfgang, B. Jung, Arnold, H. H., N. Drusenheimer, Meinhardt, Andreas, Drusenheimer, Nadja   +11 more
core   +1 more source

Publication Only

HemaSphere, Volume 10, Issue S1, June 2026.
wiley   +1 more source

Lis1 cuts its work short

Journal of Cell Biology, 2012
![Figure][1] Endosomes (green) move in normal fungi (top) but stay put if Lis1 is absent (bottom). Egan et al. clarify the role of the dynein co-factor Lis1 in cargo transport. The molecular motor dynein ferries cargoes toward the minus ends of microtubules, typically toward the nucleus.
openaire   +2 more sources

ISEV2026 Abstract Book

Journal of Extracellular Vesicles, Volume 15, Issue S1, June 2026.
wiley   +1 more source