Results 1 to 10 of about 32,692 (251)

Targeting EpCAM expression via near-infrared fluorescent antibodies enables microscopic delineation of primary and recurrent HNSCC [PDF]

BMC Cancer
Background In surgical treatment of head and neck squamous cell carcinoma (HNSCC), resection with adequate tumor-free margins is a fundamental challenge. Epithelial cell adhesion molecule (EpCAM/CD326) is substantially overexpressed in HNSCC representing
Bernd Uhl, Dennis Eggert, Bojan Smiljanov, Katharina von Thun und Hohenstein, Christoph Walz, Gisela Kranz, Sabina Schwenk-Zieger, Florian Haring, Joshua Luft, Jiahang Song, Vincent Holtmann, Philipp Baumeister, Christoph A. Reichel, Olivier Gires, Martin Canis, Christian Betz   +15 more
doaj   +2 more sources

Targeting EGFR Exon 20 Insertion-mutated Cancers – New Perspectives in Head and Neck Cancers – Lessons to Learn from Non-small Cell Carcinoma (NSCLC) [PDF]

Modern Medicine, 2022
Mutations in the tyrosine kinase (TKD) domain of the epidermal growth factor receptor (EGFR) are involved in the unfavorable therapeutic response through resistance to targeted molecular therapy.
Camil Ciprian MIRESTEAN, Roxana Irina IANCU, Dragos Teodor IANCU   +2 more
doaj   +1 more source

Clinical presentation and pattern of care for sarcomatoid variant of squamous cell carcinoma of the head-and-neck region: A retrospective study

Cancer Research, Statistics, and Treatment, 2021
Background: The sarcomatoid variant of squamous cell carcinoma (SCC) is an uncommon variant of head-and-neck cancer with a clinically aggressive course and poor outcomes. The data on the clinical presentation and pattern of treatment received by patients
Adhara Chakraborthy, Shivakumar Thiagarajan, Munita Bal, Devendra Chaukar   +3 more
doaj   +1 more source

Epithelial-Mesenchymal Transition and Inflammation in Head and Neck Squamous Cell Carcinoma [PDF]

Journal of Sciences, Islamic Republic of Iran, 2020
Head and neck squamous cell carcinoma (HNSCC) represents a large majority of cancers arising from the head and neck, especially the oral cavity. Despite advances in therapy, the five-year survival rate remains low due to the number of patients presenting
Habib Sadeghi Rad, Abbas Shakoori Garakani, Ghodratolah Panahi, Saman Mehrabi, Mohammad reza Noori daloii   +4 more
doaj   +1 more source

Molecular and clinical aspects of HNSCC in the Republic of Moldova

Romanian Journal of Laboratory Medicine, 2023
Introduction: Complex molecular characterization and integrated approaches in the basic research of HNSCC provide new insights into the understanding and treatment of these tumors.
Stratan Valentina, Țuțuianu Valeri, Sîtnic Victor, Popa Cristina, Balan Veronica, Clipca Adrian, Sclifos Ina, Monastirscaia Anastasia, Trohin Victoria, Sprincean Mariana   +9 more
doaj   +1 more source

MiR-526b-3p enhances sensitivity of head and neck squamous cell carcinoma cells to radiotherapy via suppressing exosomal LAMP3-mediated autophagy

Autoimmunity, 2023
Lysosomal associated membrane protein 3 (LAMP3) has been reported to be a tumour promoter in multiple cancer types by modulating tumour cell autophagy. However, the potential mechanism of LAMP3 in radio-resistance of head and neck squamous cell carcinoma
Huixiang Lu, Junnian Zhou, Xiaojun Li, Xiaoqin Han, Shuping Ma, Chunlan Feng   +5 more
doaj   +1 more source

Neoadjuvant chemotherapy in oral cancer: Current status and future possibilities

Cancer Research, Statistics, and Treatment, 2020
Eighty-five percent of oral cavity cancers present as locally advanced disease and are treated with multimodality approach. Patients who can undergo radical resection have the best outcomes, although the overall results are still unsatisfactory ...
Alok Goel, Anshul Singla, Kumar Prabhash
doaj   +1 more source

Functional proteomics of patient derived head and neck squamous cell carcinoma cells reveal novel applications of trametinib

Cancer Biology & Therapy, 2022
In this study, we report a differential response of mitogen-activated protein kinase–kinase (MEK) inhibitor trametinib in 20 head and neck squamous cell carcinoma (HNSCC) patients’ tumor-derived cell cultures.
Myles Vigoda, Chase Mathieson, Nathaniel Evans, Carolyn Hale, Jennifer Jennings, Olivia Lucero, Sophia Jeng, Daniel Bottomly, Daniel Clayburgh, Peter Andersen, Ryan Li, Daniel Petrisor, Jeffrey W. Tyner, Shannon McWeeney, Molly Kulesz-Martin   +14 more
doaj   +1 more source

In vivo CRISPR screens reveal potent driver mutations in head and neck cancers

Molecular & Cellular Oncology, 2020
We have recently tested the transforming potential of 484 ‘long-tail’ genes, which are recurrently albeit infrequently mutated in head and neck cancers (HNSCC).
Sampath Kumar Loganathan, Daniel Schramek   +1 more
doaj   +1 more source

EGFR/PI3K/Akt/mTOR pathway in head and neck squamous cell carcinoma patients with different HPV status

Polish Journal of Pathology, 2022
The aim of the study was to compare prognostic potential of PIK3CA mutations and expression of proteins involved in or regulate EGFR/PI3K/Akt/mTOR signaling in HPV16 positive and HPV negative head and neck squamous cell carcinoma (HNSCC) patients.
Anna Janecka-Widła, Kaja Majchrzyk, Anna Mucha-Małecka, Beata Biesaga   +3 more
doaj   +1 more source