Results 31 to 40 of about 32,408 (167)

Design and Synthesis of Arf1-Targeting γ-Dipeptides as Potential Agents against Head and Neck Squamous Cell Carcinoma

Cells, 2020
Background: Head and neck squamous cell carcinoma (HNSCC) is one of the leading causes of cancer-related deaths and calls for new druggable targets. We have previously highlighted the critical role of ADP-ribosylation factor-1 (Arf1) activation in HNSCC.
Yen Vo-Hoang, Sergio Paiva, Leilei He, Sébastien Estaran, Yong Teng   +4 more
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Research Progress of Ferroptosis in Head and Neck Squamous Cell Carcinoma

Zhongliu Fangzhi Yanjiu, 2022
Squamous cell carcinoma of the head and neck (HNSCC) is one of the cancers with the highest incidence rate in the world. Due to the presence of postoperative recurrence and resistance to some chemotherapeutics after the surgery, the prognosis of advanced
XIE Zhanghong, HUA Qingquan
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FTH1 indicates poor prognosis and promotes metastasis in head and neck squamous cell carcinoma [PDF]

PeerJ, 2023
Background Currently, ferritin heavy chain (FTH1) has been increasingly found to play a crucial role in cancer as a core regulator of ferroptosis, while its role of non-ferroptosis in head and neck squamous cell carcinoma (HNSCC) is still unclear ...
Qingyun Liao, Jing Yang, Zhaoyi Lu, Qingshan Jiang, Yongqian Gong, Lijun Liu, Hong Peng, Qin Wang, Xin Zhang, Zhifeng Liu   +9 more
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Anti-CD47 treatment enhances anti-tumor T-cell immunity and improves immunosuppressive environment in head and neck squamous cell carcinoma

OncoImmunology, 2018
Head and neck squamous cell carcinoma (HNSCC) is considered as an immunosuppressive disease, with impaired tumor-infiltrating T lymphocytes and increased suppressive immune cells.
Lei Wu, Guang-Tao Yu, Wei-Wei Deng, Liang Mao, Lei-Lei Yang, Si-Rui Ma, Lin-Lin Bu, Ashok B. Kulkarni, Wen-Feng Zhang, Lu Zhang, Zhi-Jun Sun   +10 more
doaj   +1 more source

Exosomal microRNAs Targeting TP53 Gene as Promising Prognostic Markers for Head and Neck Squamous Cell Carcinoma

Global Medical Genetics, 2022
Statement of Problem MicroRNAs are small non-coding RNAs that regulate an array of functions by targeting crucial genes. A significant dysregulation in the TP53 profile has been observed in the head and neck squamous cell carcinoma (HNSCC) patients ...
Vijayashree Priyadharsini Jayaseelan, Paramasivam Arumugam   +1 more
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Associations of GWAS-Identified Risk Loci with Progression, Efficacy and Toxicity of Radiotherapy of Head and Neck Squamous Cell Carcinoma Treated with Radiotherapy

Pharmacogenomics and Personalized Medicine, 2021
Qinghuan Li,1,* Yi Liang,1,* Zeng Liu,2 Chuanyun Yu1 1Oncology Radiotherapy Center, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, Hubei, 441021, People’s Republic of China; 2Department of ...
Li Q, Liang Y, Liu Z, Yu C
doaj  

Brusatol, a Nrf2 Inhibitor Targets STAT3 Signaling Cascade in Head and Neck Squamous Cell Carcinoma

Biomolecules, 2019
STAT3 is a latent transcription factor that plays a vital role in the transmission of extracellular signal from receptors to the nucleus. It has been regarded as a master transcription factor due to its role in the regulation of a broad spectrum of genes,
Jong Hyun Lee, Shobith Rangappa, Chakrabhavi Dhananjaya Mohan, Basappa, Gautam Sethi, Zhi-Xiu Lin, Kanchugarakoppal S. Rangappa, Kwang Seok Ahn   +7 more
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PRF1 is a prognostic marker and correlated with immune infiltration in head and neck squamous cell carcinoma

Translational Oncology, 2021
Purpose: Head and neck squamous cell carcinoma (HNSCC) is a highly invasive malignancy with poor survival. Perforin (PRF1) plays essential roles in host immunity.
Cui Fan, Haixia Hu, Yilin Shen, Quan Wang, Yufeng Mao, Bin Ye, Mingliang Xiang   +6 more
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Depth of tumor infiltration as a prognosticator in pT1-2 cN0 oral squamous cell carcinoma thereby need for elective neck dissection – A meta-analysis

Cancer Research, Statistics, and Treatment, 2019
Aim: The aim of the study is to identify the cutoff value for depth of infiltration that predicts the risk of lymph node metastasis in the neck in surgically treated patients affected by pT1/pT2 cN0 oral squamous cell carcinoma (OSCC).
Mohammad Akheel, Rinku K George, Amit Jain, Qutubuddin Chahwala, Ashmi Wadhwania   +4 more
doaj   +1 more source

Machine learning with the TCGA-HNSC dataset: improving usability by addressing inconsistency, sparsity, and high-dimensionality

BMC Bioinformatics, 2019
Background In the era of precision oncology and publicly available datasets, the amount of information available for each patient case has dramatically increased.
Michael C. Rendleman, John M. Buatti, Terry A. Braun, Brian J. Smith, Chibuzo Nwakama, Reinhard R. Beichel, Bart Brown, Thomas L. Casavant   +7 more
doaj   +1 more source