Results 51 to 60 of about 32,692 (251)

Identification of a potential prognostic panel of biomarkers for stratification of head and neck squamous cell carcinoma based on HPV status and TP53 mutational status

Oral Oncology Reports, 2023
Head and Neck Squamous Cell Carcinoma (HNSCC) is a malignant cancer with poor prognosis. Currently, the prognosis of HNSCC is determined by clinical and histopathological criteria. This work focused on identifying a panel of genes that have the potential
Oriana Barros, Rita Ferreira, Vito G. D'Agostino, Francisco Amado, Lucio Santos, Rui Vitorino   +5 more
doaj   +1 more source

Advances in immunotherapy for HNSCC

Serican Journal of Medicine
Head and Neck Squamous Cell Carcinoma (HNSCC) is a cancer that originates in the mucosal surfaces of the head and neck, including the mouth, throat, and larynx. Immunotherapy has emerged as a promising treatment for HNSCC, especially for patients whose cancers are resistant to traditional therapies such as surgery, radiation, and chemotherapy.
Lin Dong, Haixia Xu, Xionghao Pang, Yiqian Liu, Meixiang Li   +4 more
openaire   +1 more source

Review of biomarkers for response to immunotherapy in HNSCC microenvironment

Frontiers in Oncology, 2023
Head and neck squamous cell carcinoma are one of the most common types of cancer worldwide. Although a variety of treatment methods such as surgery, radiotherapy, chemotherapy, and targeted therapy are widely used in diagnosing and treating HNSCC, the survival prognosis of patients has not been significantly improved in the past decades. As an emerging
Shaoshi Chen, Yifan Yang, Shizhi He, Meng Lian, Ru Wang, Jugao Fang   +5 more
openaire   +3 more sources

A Non‐Canonical Role of SMAD4 in Regulating 3D Genome Architecture to Inhibit Lung Squamous Cell Carcinoma Development

Advanced Science, EarlyView.
SMAD4 is identified as a guardian of 3D genome architecture in lung squamous cell carcinoma. Loss of SMAD4 unleashes EP300 at chromatin loop anchors, strengthening enhancer–promoter looping and H3K27ac at the SOX2 locus to drive aberrant SOX2 activation and tumor cell proliferation.
Qian Tang, Chen Lian, Xinyan Han, Xuhan Zhang, Zihan Wang, Boyu Wang, Taoyu Zhu, Xinrui Lin, Xiaolei Wang, Yaping Xu, Manyu Xiao, Zijin Wang, Junming Li, Silin Chen, Yunze Wang, Yufei Liu, Songsong Li, Zuolin Shen, Xi Lu, Xueqi Han, Yilu Zhou, Mingyang Xiao, Jiayi Ran, Xiaoran Cao, Xinyi Xu, Hugo Sámano‐Sánchez, Alfredo Rodríguez, Lian Wang, Shuifang Chen, Zhanyu Xu, Shirong Zhang, Nuo Yang, Yong Tang, Jian Liu   +33 more
wiley   +1 more source

PD-L1 in Combination with CD8+TIL and HIF-1α are Promising Prognosis Predictors of Head and Neck Squamous Cell Carcinoma

Cancer Management and Research, 2020
Zihan Zhou,1,2 Dianbin Mu,3 Dexian Zhang,3 Xianbin Zhang,2 Xingchen Ding,2 Jia Yang,2 Xinbin Bai,4 Man Hu2 1Department of Oncology, Weifang Medical University, Weifang, Shandong, People’s Republic of China; 2Department of Radiation Oncology ...
Zhou Z, Mu D, Zhang D, Zhang X, Ding X, Yang J, Bai X, Hu M   +7 more
doaj  

Nivolumab Doubles Survival for Patients with HNSCC [PDF]

Cancer Discovery, 2016
Abstract In patients with head and neck squamous cell carcinoma refractory to platinum-based chemotherapy, those treated with nivolumab had a 30% reduction in the risk of death compared with those assigned to receive one of three single-agent chemotherapies, according to a recent phase III trial.
openaire   +2 more sources

HLA‐DR+ Schwann Cells Generate the Protumor Cancer‐Neuron‐Immune Niche in Head and Neck Squamous Cell Carcinoma

Advanced Science, EarlyView.
Hijacked and educated by HNSCC cells, HLA‐DR+ Schwann cells lost their normal neural‐related functions but acquired immunoregulatory phenotypes to promote CD4+ T cells transform into Tregs. HLA‐DR+ Schwann cells induced a macrophage subpopulation, Il1β.
Xiaoyan Meng, Zhonglong Liu, Shijian Zhang, Luoman Gan, Liren Cao, Jingjing Sun, Lingfang Zhang, Yue He   +7 more
wiley   +1 more source

Cetuximab Plus Chemotherapy versus Chemotherapy Alone in Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma: A Cost-Effectiveness Analysis

Cancer Management and Research, 2020
Yitian Lang,1,2 Deshi Dong1,2 1Department of Pharmacy, The First Affiliated Hospital of Dalian Medical University, Dalian, People’s Republic of China; 2College of Pharmacy, Dalian Medical University, Dalian, People’s Republic of ...
Lang Y, Dong D
doaj  

CD73 is associated with poor prognosis in HNSCC

Oncotarget, 2016
CD73 is a cell surface immunosuppressive enzyme involved in tumor progression and metastasis. While patients whose cancer cells express elevated CD73 are typically associated with an unfavorable outcome, the clinical impact of CD73 expression in patients with Head and neck squamous cell carcinoma (HNSCC) remains unclear.
Ren, Zhen-Hu, Lin, Cheng-Zhong, Cao, Wei, Yang, Rong, Lu, Wei, Liu, Zhe-Qi, Chen, Yi-Ming, Yang, Xi, Tian, Zhen, Wang, Li-Zhen, Li, Jiang, Wang, Xu, Chen, Wan-Tao, Ji, Tong, Zhang, Chen-Ping   +14 more
openaire   +3 more sources

PDGFRα+/Integrin α2+ Fibroblasts Orchestrate Tumor Budding in Oral Squamous Cell Carcinoma via Mechano‐Metabolic Symbiosis: E‐Cadherin/Integrin α2β1 Adhesion and Mitochondrial Transfer

Advanced Science, EarlyView.
PDGFA/PDGFRα signaling recruits CAFs to OSCC nests, and CAF‐OSCC contact drives tumor budding invasion. Mechanistically, heterotypic adhesion via E‐cadherin/integrin α2β1 activates YAP signaling in OSCC cells, inducing EMT. Concurrently, CAFs transfer mitochondria through TNTs, supplying ATP to fuel invasion.
Yufang Liu, Jiao Li, Juan Liu, Qi Dong, Haoyang Zhang, Yanjin Wang, Huibing Li, Ye Guan, Lei Cao, Manqing Zhang, Fangning Guo, Xue Liu, Zhen Yang, Mengmeng Lu, Hui Liu, Laiping Zhong, Tong Ji, Tingjiao Liu   +17 more
wiley   +1 more source