Results 11 to 20 of about 47,439 (299)
Incidence and survival of HNSCC patients living with HIV compared with HIV-negative HNSCC patients [PDF]
European Archives of Oto-Rhino-Laryngology, 2021 Abstract Purpose The aim was to analyze the incidence and survival of patients living with HIV (PLWH) with head and neck squamous cell carcinoma (HNSCC) and to compare with a control group of HIV-negative HNSCC patients.
Carmen Stromberger +2 more
exaly +6 more sources
HNSCC: Tumour Antigens and Their Targeting by Immunotherapy [PDF]
Cells, 2020 Head and neck squamous cell carcinomas (HNSCC) are a heterogeneous group of malignant tumours typically caused by alcohol and tobacco consumption, although an increasing number of HNSCC arise due to persistent infection with high-risk human papilloma virus (HPV).
Simon Laban +2 more
exaly +6 more sources
lncRNA in HNSCC: challenges and potential [PDF]
Współczesna Onkologia, 2017 Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cause of cancer mortality in the world. Some progress has been made in the therapy of HNSCC, however treatment remains unsatisfactory. Recent studies have shown that different types of long non-coding RNAs (lncRNAs) are dysregulated in HNSCC and correlate with tumor progression ...
Kacper Guglas +8 more
openaire +5 more sources
NR2F6 as a Prognostic Biomarker in HNSCC [PDF]
International Journal of Molecular Sciences, 2020 Head and neck squamous cell carcinoma (HNSCC)is the 6th most common cancer in humans worldwide and is associated with a poor prognosis for patients. NR2F6 has been identified as an immune checkpoint molecule in tumor-infiltrating T lymphocytes and is associated with a poor prognostic outcome in various cancers.
Luise Klapper +10 more
openaire +3 more sources
NF-Y Subunits Overexpression in HNSCC [PDF]
Cancers, 2021 NF-Y is the CCAAT-binding trimer formed by the histone fold domain (HFD), NF-YB/NF-YC and NF-YA. The CCAAT box is generally prevalent in promoters of “cancer” genes. We reported the overexpression of NF-YA in BRCA, LUAD and LUSC, and of all subunits in HCC. Altered splicing of NF-YA was found in breast and lung cancer.
Andrea Bernardini +2 more
exaly +3 more sources
Advances in immunotherapy for HNSCC [PDF]
Serican Journal of MedicineHead and Neck Squamous Cell Carcinoma (HNSCC) is a cancer that originates in the mucosal surfaces of the head and neck, including the mouth, throat, and larynx. Immunotherapy has emerged as a promising treatment for HNSCC, especially for patients whose cancers are resistant to traditional therapies such as surgery, radiation, and chemotherapy.
Lin Dong +4 more
openaire +2 more sources
GDNF secreted by nerves enhances PD-L1 expression via JAK2-STAT1 signaling activation in HNSCC
OncoImmunology, 2017 Programmed death ligand 1 (PD-L1) functions as a key immune inhibitory factor by binding with its receptor, programmed death 1 (PD-1), to induce immune cell dysfunction and escape of the immune system.
Wei Cao, Xu Wang, Zhenhu Ren
exaly +2 more sources
DDX21 Enhances Radiosensitivity in Head and Neck Squamous Cell Carcinoma by Suppressing MK2-Mediated DNA Damage Response. [PDF]
Adv Sci (Weinh)DDX21 suppresses MK2 activation by directly inhibiting Thr334 phosphorylation in a p38‐independent manner, thereby impairing DNA damage response. Clinically, patients with well‐differentiated tumors exhibiting high DDX21 expression are more likely to benefit from adjuvant radiotherapy, whereas those with low DDX21 levels are predisposed to ...
Yang T +8 more
europepmc +2 more sources
Regulation of the lncRNA NEAT1 by p53-ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC. [PDF]
Mol OncolIn head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
De Domenico S +5 more
europepmc +2 more sources
Targeting EGFR Exon 20 Insertion-mutated Cancers – New Perspectives in Head and Neck Cancers – Lessons to Learn from Non-small Cell Carcinoma (NSCLC) [PDF]
Modern Medicine, 2022 Mutations in the tyrosine kinase (TKD) domain of the epidermal growth factor receptor (EGFR) are involved in the unfavorable therapeutic response through resistance to targeted molecular therapy.
Camil Ciprian MIRESTEAN +2 more
doaj +1 more source